비선형 반군(非線型半群)과 축소작용소(縮小作用素)

한창우 한국수학교육학회 1976 수학교육 Vol.15 No.1

本論文에서는 Banach 空間에서의 非線形 縮小作用素의 半群에 대하여 조사하고 非線形 半群에서의 生成作用素의 生成을 論하였다.

태아수종 및 선천성 심장병에 동반된 난치성 상심실성 빈맥을 보이는 미숙아에서 Amiodarone및 Digoxin 병합 치료 1례

한창우,유하양,신정은,은호선,이순민,박민수,남궁란,이철,박국인 대한신생아학회 2014 Neonatal medicine Vol.21 No.1

Fetal tachycardia is at risk for developing low cardiac output, non-immune hydrops fetalis and ultimately fetal death. Spontaneous resolution of supraventricular tachycardia (SVT) is common during the first year of age, but some infants need long-term antiarrhythmic therapy. In almost neonatal tachyarrhythmia including SVT, adenosine is the drug of the first choice. Digoxin is used to treat the SVT which is not controlled with adenosine. Class Ic and III antiarrhythmic drugs are additionally recommended for the disease unresponsive to digoxin. Intravenous amiodarone is highly effective and safe in an infant with refractory or life threatening tachycardia. Some cases have been reported that amiodarone combined with digoxin therapy is effective for treating tachycardia. We herein report a case of a preterm infant–born at 32 weeks of gestational age–with hydrops fetalis and life-threatening refractory SVT accompanied by multiple congenital heart diseases. SVT was initially not responsive to adenosine therapy, however, it was then successfully controlled with combination therapies of amiodarone and digoxin. 태아 부정맥(fetal arrhythmia)은 비면역학적 이상으로 인한 태아수종 (hydrops fetalis)을 유발하는 대표적인 원인중의 하나로, 궁극적으로 태아의 사망에 이를 수 있다. 상심실성 빈맥(supraventricular tachycardia)은 대부분 1세이전에 자연 소실 되나, 일부에서 장기간 항부간정맥(antiarrhythmic drugs)치료를 필요로 한다. 상심실성 빈맥을포함한 대부분의 신생아 빈맥에서 아데노신(adenosine)은 첫 번째로 사용되는 약물이다. 아데노신으로 조절되지않는 상심실성 빈맥의 경우 디곡신(digoxin)을 사용하여 조절 한다. 디곡신에 반응 하지 않는 경우 제 1 c 군과 제3군 항부정맥제의 사용이 추천된다. 아미오다론 (amiodarone)은 난치성 혹은 생명을 위협하는 빈맥을 보이는 영아에서 좋은 치료 효과를 보이나, 일부에서는 디곡신과의 병합요법을 통해 더 높은 치료 성적을 보고 하였다. 본증례는 태아빈맥, 태아-수종 및 선천성 심장병이 동반된 재태연령 32주 미숙아로 출생한 환아에서, 출생 후 계속하여 상심실성 빈맥을 보여 아데노신을 투여 하였으나 조절되지 않아, amiodarone과 digoxin을 병합 투여하여 빈맥이 치료되어 보고하는 바이다.

모듈 분리형 가이드 레일의 안정성 해석

한창우,손재환,장원석,김철홍 한국자동차공학회 2016 한국자동차공학회 지부 학술대회 논문집 Vol.2016 No.10

An Experimental Infarct Targeting the Internal Capsule: Histopathological and Ultrastructural Changes

한창우,이민철,이경화,노명균,김진명,김형석,김형선,김라경,조종욱,김형일 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.3

Background: Stroke involving the cerebral white matter (WM) has increased in prevalence, but most experimental studies have focused on ischemic injury of the gray matter. This study was performed to investigate the WM in a unique rat model of photothrombotic infarct targeting the posterior limb of internal capsule (PLIC), focusing on the identification of the most vulnerable structure in WM by ischemic injury, subsequent glial reaction to the injury, and the fundamental histopathologic feature causing different neurologic outcomes. Methods: Light microscopy with immunohistochemical stains and electron microscopic examinations of the lesion were performed between 3 hours and 21 days post-ischemic injury. Results: Initial pathological change develops in myelinated axon, concomitantly with reactive change of astrocytes. The first pathology to present is nodular loosening to separate the myelin sheath with axonal wrinkling. Subsequent pathologies include rupture of the myelin sheath with extrusion of axonal organelles, progressive necrosis, oligodendrocyte degeneration and death, and reactive gliosis. Increase of glial fibrillary acidic protein (GFAP) immunoreactivity is an early event in the ischemic lesion. WM pathologies result in motor dysfunction. Motor function recovery after the infarct was correlated to the extent of PLIC injury proper rather than the infarct volume. Conclusions: Pathologic changes indicate that the cerebral WM, independent of cortical neurons, is highly vulnerable to the effects of focal ischemia, among which myelin sheath is first damaged. Early increase of GFAP immunoreactivity indicates that astrocyte response initially begins with myelinated axonal injury, and supports the biologic role related to WM injury or plasticity. The reaction of astrocytes in the experimental model might be important for the study of pathogenesis and treatment of the WM stroke.

내장감각과민의 침구 치료에 대한 실험연구 현황: PubMed를 중심으로

한창우,최준용,박성하,김소연 경락경혈학회 2019 Korean Journal of Acupuncture Vol.36 No.2

Objectives : The aim of this study is to review the current trends in experimental studies on the acupuncture moxibustion treatment for visceral hypersensitivity. Methods : PubMed was searched for experimental studies about visceral hypersensitivity and acupuncture/moxibustion. Data were extracted and tabulated from the selected articles about experimental method, intervention, result and mechanism. Results : Total 23 articles were reviewed. Chronic visceral hypersensitivity animal model was applied in 17 studies (74%). Visceral hypersensitivity was measured by abdominal withdrawal reflex scoring or/and abdominal electromyogram. Acupoints like ST25, ST36, ST37, BL25, LI11, BL32 and PC6 were treated by electroacupuncture or moxibustion. All articles reported that electroacupuncture or moxibustion treatment is significantly effective in reducing visceral hypersensitivity. Treatment mechanisms were studied, related to mast cell, serotonin (5-HT) and receptor (5-HT3R and 5-HT4R), substance P (SP), vasoactive intestinal polypeptide (VIP), c-fos positive cell, corticotropin-releasing hormone (CRH), purinergic 2X (P2X)2, P2X3, P2X4, P2X7, N-methyl-D-aspartate (NMDA) receptor (NR1 and NR2B), prokinectin (PK) 1 and PK2. Conclusions : Evidences on acupuncture/moxibustion treatment for visceral hypersensitivity in animal studies warrant more research on effective acupoins, electro-acupuncture methods and treatment durations.

Clean Stocker내 새로운 방식의 기류제어에 관한 연구(II)

한창우,최기한,이상룡 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.6

한.양방 입원 환자의 비정상 간기능 검사 발생률 비교

한창우,Han, Chang-Woo 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.1

Herbal hepatotoxicity is a one of the most often encountered controversial issues in medical society. Some believe herbs are totally safe while others regard treatment with herbs as a very common cause of hepatotoxicity. But there are no comparative clinical hepatotoxicity studies between herbal and conventional medicines. We investigated incidence of patients with abnormal liver function who were treated with herbal or conventional medicine at Dongguk University International Hospital. Each group consisted of 300 patients, who were admitted for longer than 30 days during the year 2008. We compared albumin, total bilirubin, AST (aspartate aminotransferase), and ALT (alanine aminotransferase) levels, and excludes patients who had abnormal liver function test or liver-related disease when admitted. As a result, incidence of total bilirubin, AST, and ALT elevation in the CT (conventional treatment) group was more frequent than in the TKM (traditional Korean medicine) group (p<0.05) during admission. Albumin level also decreased more frequently in the CT group than in the TKM group (p<0.05). According to these results, herbal medicine is not more hepatotoxic than conventional medicine, and not a main cause of liver injury in inpatients.

淸肝解酒湯이 kupffer cell의 NFkB 활성화 및 세포사멸에 미치는 영향

한창우,김영철,이장훈,우홍정 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1

Entecavir와 한의약 치료를 병행한 후 HBV-DNA가 음전된 만성 B형 간염 환자 증례 보고

한창우,Han, Chang-woo 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

The patient presented to the clinic with the complaint of severe fatigue. The patient had been diagnosed with chronic hepatitis B a number of years earlier. Although he had used entecavir, an antiviral agent, for over two years, his HBV-DNA level had not dropped below undetectable levels. The fatigue seemed to be associated with chronic hepatitis B. Traditional Korean medicine (TKM) therapy for chronic hepatitis B was administered in conjunction with entecavir and at the same dose. The excessive fatigue gradually decreased following the treatment. On the 28th day, laboratory tests revealed that the patient's bilirubin level was slightly lower and that his HBV-DNA level had dropped below undetectable levels. The addition of TKM therapy may have contributed to the HBV-DNA clearance. No similar cases have been reported in Korea. Herein, we summarize the patient's progress.

극저탄소강의 Mash Seam TB 용접성 평가에 관한 연구

한창우,이창희,이명호 대한용접접합학회 2002 대한용접·접합학회지 Vol.20 No.4

M/S TB(Mash Seam Tailored Blank) is a production method for blanks by welding together blanks of different material, thickness and coating, and is an attractive method for manufacturing car body because it makes parts lighter and can save the cost and time to manufacture. However, there have not been quantified criteria to evaluate the quality of TB weld. This study introduced FHR (failure height ratio) in order to assess formability or/and weldability of the M/S welds and the applicability of FHR was confirmed by actual auto body forming and FLD tests. Furthermore, a new parameter, HN(heat number) based on the heat input of "$Q=I^2Rt$" was proposed and assessed. It was found that the concept of HN could be utilized to evaluate the soundness of M/S welds without any destructive tests.ive tests.