천연물 신약 특허 동향 분석

한유진,박선주,Han, Yoo-Jin,Park, Sunju 대한예방한의학회 2016 대한예방한의학회지 Vol.20 No.2

Objectives : This study aims to investigate the current situation of domestic patents in Korea on natural products and to provide directions for developing and applying herbal medicinal products by in-depth analyses. Methods : Combinations of words, such as "A61K" or "A61P", "herb" or "Korean medicinal herb" or "Korean medicine" or "traditional" or "natural" or "$botanic^*$" or "China", and "medicine" or "treatment" or "prevention" or "improvement", were used to search patents in the World Intellectual Property Service (WIPS) database. Three methods were applied to analyze natural products patents. First, the number of patent registrations was sorted by year. Second, the assignees were analyzed by count and country of origin. Finally, cluster map analysis was conducted to explore frequently emerging words in natural products and the relationship amongst those words to treat corresponding diseases/technologies. Results : Results showed that, first, the total number of patents had been increasing. Among the patents, 76.4% were registered by domestic institutes/companies, and 23.6% by foreign institutes/companies. Second, USA, Japan, and China possess a considerable number of Korean patents and, therefore, domestic institutes/companies can seek joint technological development opportunities with their counterparts from those countries in the future. Finally, a total of four clusters were identified by cluster map analysis. Each of the clusters includes natural products related to diseases involving skin, aging, and blood sugar, as well as adult diseases. Conclusions : In this study, natural products patents registered in the Korean Intellectual Property Office were analyzed. The analyses results showed the kinds of natural products that had been employed for the treatment of certain diseases. However, natural products included in existing patents were minimal given that 4,174 species of indigenous plants are found in Korea. Thus, Korean institutes/companies should utilize unexplored plants to develop more value-added drugs.

Carrageenan 유발염증에 대한 15Hz 전침의 효과에 대한 연구

한유진,이용태,장경전,Han, You-jin,Lee, Yong-tae,Jang, Kyung-jeon 대한침구의학회 2003 대한침구의학회지 Vol.20 No.3

Objective : The aim of this study is to investigate the anti-inflammatory effects of 15Hz electroacupuncture(EA) on carrageenan-injected rats. Inflammation was induced by an intraplantar injection of 1% carrageenan into the right hind paw. Methods : Bilateral EA stimulation with 15 Hz were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles for a total of 30 min duration in carrageenan-injected rats. Results: The developing edema was measured 30 minutes interval afer carrageenan injection and 15 Hz EA stimulation presented significant edema inhibition. Three hours after carrageenan injection, prostaglandin $E_2(PGE_2)$ and nitric oxide(NO) levels were measured. The 15Hz EA stimulation significantly inhibited $PGE_2$ and NO production in the right paw. The pro-inflammatory mRNA expression such as cyclooxygenases(COX)-2 and interleukin(IL)-$1{\beta}$ were slightly down-regulated by EA stimulation. The number of COX-2, IL-$1{\beta}$, tumor necrosis factor-${\alpha}$ immunoreactive cells were abundantly observed in paw edema. But these cells were decreased in nmber according to anti-edema effect of 15Hz EA. Conclusions: These results indicate that 15Hz EA stimulation have an alleviation action against carrageenan-induced edema and local inflammation.

아동과 청소년의 우울성향 (憂鬱性向) 및 귀인양식과 (歸因樣式) 학업성취

한유진,유안진 ( Eu Gene Han,An Jin Yoo ) 대한가정학회 1994 Human Ecology Research(HER) Vol.32 No.3

부모의 정서 규제와 아동의 정서 표출 규칙 이해

한유진,유안진 ( Eu Gene Han,An Jin Yoo ) 대한가정학회 1998 Human Ecology Research(HER) Vol.36 No.11

Report - 국가 R&D 특허의 ASEAN 주요국가 지원 방안

한유진,Han, Yu-Jin 한국발명진흥회 2011 發明特許 Vol.36 No.12

특허청 '11년 계획에 ASEAN+3(한 중 일)을 언급하였으나 구체적인 실행 계획은 미흡한 상태이다. ASEAN은 동남아시아 경제협의체로서 우리나라와 지리적 무역 측면에 있어서 매우 가까우며, 회원국 대부분이 과학기술을 개발할 수 있는 최소한의 인프라가 갖추어져 있고 정부의 의지도 뚜렷한 편이다. 주요 협력 대상국으로 말레이시아('08년 2,086건 등록) 필리핀('08년 838건 등록), 태국('08년 966건 등록)을 선정하였다.

유망기술을 보는 여러 가지 관점

한유진,Han, Yu-Jin 한국발명진흥회 2007 發明特許 Vol.33 No.1

뇌전증 환자의 MEG 데이터에 대한 분류를 위한 인공신경망 적용 연구

한유진,김준식,김재희,Yujin Han,Junsik Kim,Jaehee Kim 한국통계학회 2024 응용통계연구 Vol.37 No.2

This study performed a multi-classification task to classify mesial temporal lobe epilepsy with left hippocampal sclerosis patients (left mTLE), mesial temporal lobe epilepsy with right hippocampal sclerosis (right mTLE), and healthy controls (HC) using magnetoencephalography (MEG) data. We applied various artificial neural networks and compared the results. As a result of modeling with convolutional neural networks (CNN), recurrent neural networks (RNN), and graph neural networks (GNN), the average k-fold accuracy was excellent in the order of CNN-based model, GNN-based model, and RNN-based model. The wall time was excellent in the order of RNN-based model, GNN-based model, and CNN-based model. The graph neural network, which shows good figures in accuracy, performance, and time, and has excellent scalability of network data, is the most suitable model for brain research in the future.

씨내리 소재 설화(說話)에 나타난 부부 간 권력관계의 불균형과 폭력의 문제 -남편의 폭력적 명령에 대응하는 아내의 행위 방식을 중심으로-

한유진(韓裕珍) ( Han Yu-jin ) 한국어문교육연구회 2021 어문연구(語文硏究) Vol.49 No.1

본 연구는 『韓國口碑文學大系』에 수록된 씨내리 소재 설화 53편을 대상으로, 부부 간 불균형한 위계로 인해 발생한 아내 성폭력의 구조를 남편의 명령형과 이에 대응하는 아내의 행위 방식을 통해 탐색하였다. 이때 아내에게 전달되는 남편의 ‘씨내리 명령’형과 이에 대응하는 ‘아내의 행위’는 다양한 형태로 나타난다. 첫째, 남편의 명령이 ‘비밀 동침’과 ‘언표(言表)되지 않은’ 형태로 나타날 경우, 서사 내에서 아내의 ‘목소리는 거세’되어 있다. 서사 내 상실된 아내 목소리의 진의(眞意)는 ‘체념에 의한 침묵’이거나, 화자에 의해 의도적으로 누락된 남편에 의해 ‘묵살된 거부 의사’이다. 둘째, 남편이 아내에게 일방적 ‘씨내리 결정을 통보’할 경우 아내는 이와 같은 결정에 ‘순종’한다. 남편의 말에 대한 아내의 순종은 승낙을 하지 않을 시 놓일 ‘위협으로 인한 순응’이거나, 사회적 ‘성역할에 의거한 동의’이다. 셋째, 아내가 남편의 ‘씨내리 명령을 적극 수행’하는 경우는, 아내가 다른 남성과의 동침을 집요하게 요구한 남편의 강요에 씨내리 남성을 ‘유혹하여 동침’하거나, 남편의 계승 고민을 자신에게 ‘과도하게 투사’함으로써 직접 씨내리를 결정하고 씨내리남성과 동침한다. This study investigated husbands’ structure of assaulting their wives sexually due to unbalanced hierarchy between couples through their orders and their wives’ acts to respond to them targeting 53 tales that feature surrogate fathers collected in the Collection of Korean Oral Literature. At this moment, the husbands’ ‘orders of the surrogate fathers’ delivered to their wives and ‘their acts’ to respond to it are shown in many different forms. First, when the husband’s orders are shown in a form of ‘sleeping together secretly’ and ‘non-verbal behaviors’, their wives’ ‘voices were deleted’ in the Narratives. Real intention of wives’ voices lost in the narratives is ‘silence by resignation’ or ‘intention of refusal’ ignored by their husbands and deliberately omitted by narrators. Second, when husbands unilaterally notify their wives of decisions of surrogate fathers, they are ‘obedient’ to them. The wives’ obedience to their husbands’ words is ‘adaptation due to threats that they will be faced with unless they will not approve’ or ‘their consent based on sex roles.’ Third, when wives ‘actively carry out their husbands’ orders of surrogate fathers’, wives ‘sleep together with men of surrogate fathers by tempting them’ by pressure of their husbands who stubbornly demand sleeping with other men. Or wives directly decide and sleep with surrogate fathers by ‘excessively reflecting’ their husbands’ worries about succession in themselves.

유아·놀이 중심 교실 속 이야기나누기의 경험과 의미

한유진(Han, Yoo-Jin),이민영(Lee, Min-Young),권혜선(Kwon, Hye-Sun) 한국열린유아교육학회 2022 열린유아교육연구 Vol.27 No.3

이 연구는 유아·놀이 중심 교육을 실천하는 교사들의 집단심층면담(FGI)을 통해 유아·놀이 중심 교실에서 교사의 이야기나누기 경험과 교사들이 형성하고 있는 이야기나누기 시간의 의미를 살펴보았다. 그 결과 첫째, 교사는 유아의 놀이와 관련된 내용에 대하여 함께 이야기를 나누며 해답을 찾아갔고, 이야기나누기 활동은 다양한 형태로 유연하게 변화하였으며, 유아들은 자신의 삶과 연결된 이야기를 나누며 즐겁게 소통하는 경험을 하였다. 둘째, 교사들은 유아·놀이 중심의 이야기나누기를 실천하는 과정에서 유아들이 이야기를 통해 앎을 나눔으로써 놀이와 배움을 이어갔고, 삶을 나눔으로써 소통하고 관계를 맺어갔으며, 그리고 공동체의 가치를 함께 나눔으로써 공동체의 일원으로 행동하고 성장하였다는 의미를 형성하였다. 연구 결과를 토대로 유아의 목소리로부터 발현되고 놀이와 연계되어 유아의 배움을 지원하는 이야기나누기 활동의 실천 방향을 논의하였다. This study set out to examine teachers’ circle-time experiences and the meanings of their circle-time hours in a child․play-centered classroom by conducting a focus group interview(FGI) with teachers that practiced child·play-centered education. The findings were as follows: first, teachers worked together to share stories and find answers regarding content related to children’s play. Their circle-time activities changed flexibly in various forms. Young children experienced happy communication, sharing sotries connected to their lives. Secondly, teachers established the following meanings in the process of practicing a child·play-centered circle-time: young children continued their play and learning by sharing their knowledge through stories, communicated and formed relationships by sharing their lives, and behaved and grew up as members of the community by sharing their community values. Based on these findings, the study discussed the direction of practicing circle activities to be manifested from young children’s voices and get connected with their play to support their learning.

강건한 Pose Estimation을 위한 이전 프레임 기반 Bounding Box 확장 기법

한유진(Yu-Jin Han),김태완(Tae-Wan Kim) 대한전자공학회 2024 대한전자공학회 학술대회 Vol.2024 No.6