산불진화대원의 복제 디자인 개발에 관한 연구

한송희,김명철,이예은,김성용,권춘근 (사)위기관리이론과실천 2023 Crisisonomy Vol.19 No.8

본 연구에서는 국내 산불진화복 현황 조사 후 개선방향 도출을 통해 신규 진화복 디자인을 개발하고자하였다. 문헌조사를 통한 국외 산불진화복 디자인 관련 자료를 수집하였고, 착용자를 대상으로 설문조사와 토론회를 실시하였다. 조사 결과 주요 개선사항으로는 활동성, 기능성, 안전성, 이동성, 디자인이었다. 디자인 개선 방향성을 도출하여 배색형, 솔리드형, 수납형의 산불진화복을 설계하였고 최종품평회를통해 솔리드형으로 결정하였다. 솔리드형 산불진화복은 신축성을 위한 스판원단을 적용하였고 소지품보관을 위해 수납성을 강화하였다. 또한 가시성 확보를 위해 재귀반사 필름 및 소재칼라를 이용하여포인트를 주었다. 본 연구는 산불진화복제 디자인 개발 및 개선사항을 통하여 진화대원의 안전사고예방과 더불어 산불진화복 관리시스템의 전반적 검토 및 산불진화복 개발을 위한 다양한 가능성을제시해줄 것으로 기대된다.

Mesothelin Expression in Gastric Adenocarcinoma and Its Relation to Clinical Outcomes

한송희,장선희,주미,김한성 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.2

Background: Although surgical resection with chemotherapy is considered effective for patients with advanced gastric cancer, it remains the third leading cause of cancer-related death in South Korea. Several studies have reported that mesothelial markers including mesothelin, calretinin, and Wilms tumor protein 1 (WT1) were positive in variable carcinomas, associated with prognosis, and were evaluated as potential markers for targeted therapy. The aim of this study was to assess the immunohistochemical expression of mesothelial markers (mesothelin, calretinin, and WT1) in gastric adenocarcinoma and their relations to clinocopathological features and prognosis. Methods: We evaluated calretinin, WT1, and mesothelin expression by immunohistochemical staining in 117 gastric adenocarcinomas. Results: Mesothelin was positively stained in 30 cases (25.6%). Mesothelin expression was related to increased depth of invasion (p = .002), lymph node metastasis (p = .013), and presence of lymphovascular (p = .015) and perineural invasion (p = .004). Patients with mesothelin expression had significantly worse disease-free survival rate compared with that of nonmesothelin expression group (p = .024). Univariate analysis showed that mesothelin expression is related to short-term survival. None of the 117 gastric adenocarcinomas stained for calretinin or WT1. Conclusions: Mesothelin expression was associated with poor prognosis. Our results suggest that mesothelin-targeted therapy should be considered as an important therapeutic alternative for gastric adenocarcinoma patients with mesothelin expression.

선별 소변검사의 단백과 비중을 결합한 검사지표의 평가

한송희,박일규 대한진단검사의학회 2015 Laboratory Medicine Online Vol.5 No.4

Background: The 24-hr urine protein excretion test is regarded as a standard for quantitative urinary protein analysis; however, collection of urine over 24 hr is troublesome and errors may occur during the process. We obtained a test index reflecting diluted or concentrated urine by coupling the results of a simple and rapid routine urine analysis and evaluated its usefulness as a marker that quantitatively reflects the 24-hr urine protein excretion. Methods: The estimated urine protein-osmolality ratio (Pro/Osm) was obtained by two linear regression equations between urine dipstick protein and natural logarithm of the protein concentration, and between urine specific gravity (SG) and urine osmolality (Osm). Sensitivity and specificity of ‘estimated urine Pro/Osm’ and the widely used urine protein-creatinine ratio were evaluated for their efficiency in diagnosing pathological proteinuria and nephrotic proteinuria based on 24-hr urine protein excretion. Results: Moderate correlations were noted between protein concentration determined by the urine dipstick protein assay and natural logarithm of protein concentration (r=0.86) and between urine SG and urine Osm (r=0.74). The receiver operating characteristics analysis showed that an estimated urine Pro/Osm value of 0.045 had a sensitivity of 91.1% and a specificity of 88.6% for diagnosing pathological proteinuria, and a value of 0.204 had a sensitivity of 100% and a specificity of 80.4% for diagnosing nephrotic proteinuria. Conclusions: Coupling the results of urine dipstick protein and urine SG determined by the routine analysis will provide additional useful information that will make the screening of renal diseases more cost-effective. 배경: 요단백량의 정량적 측정에는 24시간 요단백 측정이 표준검사이나, 검체채취가 어려워 그 과정에서 오류가 발생하기 쉽다. 본 연구에서는 간편하고 신속한 요 선별검사 결과를 결합하여 소변의 희석 및 농축을 반영한 결과를 얻고, 24시간 요단백량을 반영하는 지표로의 유용성을 평가하고자 하였다. 방법: 요시험지봉 단백과 정량단백, 그리고 요비중과 요삼투압 사이에서 도출된 회귀곡선식을 이용하여 ‘추정 요 단백/삼투압 비’를 구하였다. 병리학적 단백뇨, 신증후군 단백뇨 진단의 24시간 요단백량을 기준으로 ‘추정 요 단백/삼투압 비’와 널리 사용되고 있는 요 단백/크레아티닌 비의 민감도와 특이도를 각각 구하여 진단적 효용성을 서로 비교평가하였다. 결과: 요시험지봉 단백과 자연 로그를 취한 단회뇨 정량단백(r=0.86)과 요비중과 요삼투압 사이(r=0.74)에서 중등의 상관관계를 보였다. 추정 요 단백/삼투압 비와 정량 측정한 요 단백/크레아티닌 비 사이에서는 0.66의 상관계수가 확인되었다. ROC 분석 결과 추정 요 단백/삼투압 비 0.045에서 병리학적 단백뇨의 진단에 91.1%의 민감도와 88.6%의 특이도를 보였고 0.204에서 신증후군 단백뇨의 진단에 100%와 80.4%의 민감도와 특이도를 보였다결론: 기본검사인 요시험지봉 단백과 요비중의 결과를 결합함으로써 신질환의 선별진단 시 비용-효과 면에서 유용한 정보를 제공할 수 있을 것으로 생각된다.

Aggregation of Water-Soluble Paclitaxel Probed by Excimer Fluorescence of the Pyrenebutyric Acid Tag

한송희,이종민,이용훈,손정선,조병욱 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.4

We have investigated the aggregation of a new water-soluble paclitaxel (7-mPEG5,000- succinyloxymethyloxycarbonyl-paclitaxel, PP7) tagged with a uorescent probe (pyrenebutyric acid, PBA) in a water solution. From the steady-state fluorescence emission spectra, we have found that the excimer uorescence of PBA tagged at PP7, centered at 470 nm, starts to appear at a con- centration of 0.30(5) μM. This critical aggregation concentration of PBA-tagged PP7 is found to be much lower by about 3000-fold than that of free PBA. The appearance of the excimer fluores- cence at such a low concentration indicates that the intermolecular interaction between the large hydrophobic parts of the paclitaxels effectively brings the fluoresent probes into proximity. Also, the decay lifetimes of the monomer and the excimer uorescence have been determined to be 9 and 78 ns in a water solution, respectively. The excimer fluorescence intensity and lifetime of PBA tagged at PP7 can be employed as useful probes for further investigation into the medical actions of this new water-soluble paclitaxel prodrug. We have investigated the aggregation of a new water-soluble paclitaxel (7-mPEG5,000- succinyloxymethyloxycarbonyl-paclitaxel, PP7) tagged with a uorescent probe (pyrenebutyric acid, PBA) in a water solution. From the steady-state fluorescence emission spectra, we have found that the excimer uorescence of PBA tagged at PP7, centered at 470 nm, starts to appear at a con- centration of 0.30(5) μM. This critical aggregation concentration of PBA-tagged PP7 is found to be much lower by about 3000-fold than that of free PBA. The appearance of the excimer fluores- cence at such a low concentration indicates that the intermolecular interaction between the large hydrophobic parts of the paclitaxels effectively brings the fluoresent probes into proximity. Also, the decay lifetimes of the monomer and the excimer uorescence have been determined to be 9 and 78 ns in a water solution, respectively. The excimer fluorescence intensity and lifetime of PBA tagged at PP7 can be employed as useful probes for further investigation into the medical actions of this new water-soluble paclitaxel prodrug.

Analysis of the Relationship between the Number of Forest Fires and Non-Rainfall Days during the 30-year in South Korea

한송희,채희문 강원대학교 산림과학연구소 2022 Journal of Forest Science Vol.38 No.4

This study examined the relationship between the number of forest fires and days with no rainfall based on the national forest fire statistics data of the Korea Forest Service and meteorological data from the Open MET Data Portal of the Korea Meteorological Administration (KMA; data.kma.go.kr) for the last 30 years (1991-2021). As for the trend in precipitation amount and non-rainfall days, the rainfall and the days with rainfall decreased in 2010 compared to those in 1990s. In terms of the number of forest fires that occurred in February–May accounted for 75% of the total number of forest fires, followed by 29% in April and 25% in March. In 2000s, the total number of forest fires was 5,226, indicating the highest forest fire activity. To analyze the relationship between regional distribution of non-rainfall periods (days) and number of forest fires, the non-rainfall period was categorized into five groups (0 days, 1-10 days, 11-20 days, 21-30 days, and 31 days or longer). During the spring fire danger season, the number of forest fires was the largest when the non-rainfall period was 11-20 days; during the autumn fire precaution period, the number of forest fires was the largest when the non-rainfall period was 1-10 days, 11-20 days, and 21-30 days, showing differences in the duration of forest fire occurrence by region. The 30-year trend indicated that large forest fires occurred only between February and May, and in terms of the relationship with the non-rainfall period groups, large fires occurred when the non-rainfall period was 1-10 days. This signifies that in spring season, the dry period continued throughout the country, indicating that even a short duration of consecutive non-rainfall days poses a high risk of large forest fires.

과학교사 모임의 형성과정, 활동목적, 연계 형태의 특징에 대한 연구

한송희 한국과학교육학회 2005 한국과학교육학회지 Vol.25 No.7

모래놀이치료가장애아동 어머니의 우울과 양육스트레스에 미치는 효과

한송희,김경희 사단법인 한국임상모래놀이치료학회 2016 상징과 모래놀이치료 Vol.7 No.2

This study applied sandplay therapy to mothers with disabled children and had them express emotions suppressed while rearing their children, thereby intending to improve their power to cope with stress through internal reinforcement that may relieve psychological recession. In order to verify the above study issues, 28 mothers were selected as subjects and equally divided into an experimental group and a control group. The experimental group received sandplay therapy for 40 minutes once per week, for a total of 10 weeks, and a test on the scale of depression and stress from child rearing was conducted prior to and after each session of sandplay therapy. The results of this study showed that sandplay therapy was effective in decreasing depression and stress from child rearing in mothers with disabled children. This study’s results are considered to provide basic data that can be utilized as a psychological therapeutic approach for seeking the stability of depressed ego resulting from depression and stress in mothers with disabled children, and also improvement in the quality of care of disabled children.

함석헌의 “참”을 향한 종교관, 인간관, 역사관 연구

한송희 한국교육철학회 2016 한국교육철학회 학술발표회 논문집 Vol.2016 No.3

Malakoplakia Affecting the Umbilical Cord

한송희,김한성,주미,장순희 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.2

1920년대 말 함석헌의 ‘신앙적 개조론’의 ‘사회 운동’적 성격 고찰 - 《성서조선》(1927~29)을 중심으로

한송희 (사)함석헌기념사업회 2023 함석헌 연구 Vol.9 No.-