http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
피부에서 자외선 B 조사에 의한 RAD50와 p53 발현의 변화
이승철(Seung Chul Lee),표원식(Won Sik Pyo),이정은(Jeong Eun Lee),원영호(Young Ho Won) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.2
N/A Background:Ultraviolet irradiation causes various changes in cells or tissues including DNA damage, which results in changes of cell cycling, mutation and cell death such as apoptosis or necrosis. p53 has been studied widely to be as a regulator gene to modulate cell cycling. Previous report shows that RAD50 is a gene to be associated with p53 to repair damaged DNA. Objective and method:In this study, we evaluated changes of RAD50 and p53 expression by ultraviolet B (UVB) irradiation in rat skin in vivo and in human fibroblasts (hF) in vitro. Results:In rat skin irradiated with 400mJ/cm2 UVB, RAD50 protein and mRNA expression were decreased by from early stage after irradiation, and they were restored to its normal level after 12 h. In hF irradiated with 20mJ/cm2 UVB, change of RAD50 expression by UVB irradiation was similar to that of rat skin. On the contrary, p53 protein expression was increased by UVB irradiation from 6 h and 3 h after UVB irradiation in rat skin and hF, respectively, but p53 mRNA expression was not changed by UVB irradiation. Conclusion:RAD50 and p53 expression is modulated differently in UVB- irradiated skin. Further studies are warrented to evaluate functional relationship between the genes in repairing damaged DNA. (Korean J Dermatol 2000;38(2):213~220)
김성진,이승철,원영호,표원식 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.6
The skin is a frequently involved organ in graft-versus-host disease(GVHD). Various skin lesions including erythematous eruption, bullae, desquamation, lichenoid, and sclerodermoid lesions have been reported in GVHD, but vitiligo-like lesions were. We present two cases of chronic GVHD presenting multiple hypopigmented patches following allogenic bone marrow transplant(BMT) due to severe aplastic anemia. The histopathologic studies showed focal vacuolar degeneration of basal cells, absence of melanocytes in the epidermis, and perivascular lymphocytic infiltration consisting of T cells in the upper dermis, These cases suggest that vitiligo-like lesions may develop due to marked melanocyte- lymphocyte interaction after BMT.