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표면거리 및 표면곡률 최적화 기반 다중모달리티 뇌영상 정합
박지영,최유주,김민정,태우석,홍승봉,김명희,Park Ji-Young,Choi Yoo-Joo,Kim Min-Jeong,Tae Woo-Suk,Hong Seung-Bong,Kim Myoung-Hee 한국정보처리학회 2004 정보처리학회논문지 A Vol.11 No.5
서로 다른 종류의 영상을 정확하게 연관시켜 복합적인 정보를 제공하는 다중모달리티 의료 영상정합기법 중 표면정보 기반 영상정합에서는 일반적으로 동일 대상에 대한 서로 다른 모달리티에서 추출된 표면 윤곽정보 사이의 거리를 최소화함으로써 매칭이 이루어진다. 그런데 동일대상에 대해 취득되는 서로 다른 두 모달리티는 관심 영역 상의 표면 특성이 서로 유사하다. 그러므로 다중모달리티 영상정합에서 표면거리와 함께 표면의 형태 특성을 고려하여 두 영상을 매칭하는 방법이 정합결과의 정확도를 향상시킬 수 있다. 본 연구에서는 동일 대상의 서로 다른 두 모달리티 뇌영상 간의 표면거리와 표면곡률을 최적화하는 정합기법을 제안한다. 영상정합은 참조영상과 테스트영상에 대한 표면정보 생성과 이 두 개의 표면정보를 최적화하는 단계로 구성된다. 표면정보 생성 단계에서는 두 모달리티로부터 관심영역의 윤곽선을 추출하고, 이 중 참조 볼륨의 윤곽선에 대해서는 표면거리맵과 표면곡률맵을 구성하게 된다. 최적화 단계에서는 표면거리맵과 표면곡률맵을 참조하는 최적화 평가함수(cost function)에 의해 두 객체의 표면거리 차이와 표면곡률 차이를 최소화하는 정합 변환 값이 결정되고, 이것이 테스트영상의 변환에 적용되어 결과적으로 두 영상이 정합 되게 된다. 제안된 최적화 평가함수는 표면거리 정보만을 사용하는 평가함수에 비해 보다 견고한 정합 정확도를 보였으며 또한 본 연구는 정합결과의 볼륨 가시화를 통해 효율적인 영상 분석 수단을 제공하고자 하였다. Within multimodal medical image registration techniques, which correlate different images and Provide integrated information, surface registration methods generally minimize the surface distance between two modalities. However, the features of two modalities acquired from one subject are similar. So, it can improve the accuracy of registration result to match two images based on optimization of both surface distance and shape feature. This research proposes a registration method which optimizes surface distance and surface curvature of two brain modalities. The registration process has two steps. First, surface information is extracted from the reference images and the test images. Next, the optimization process is performed. In the former step, the surface boundaries of regions of interest are extracted from the two modalities. And for the boundary of reference volume image, distance map and curvature map are generated. In the optimization step, a transformation minimizing both surface distance and surface curvature difference is determined by a cost function referring to the distance map and curvature map. The applying of the result transformation makes test volume be registered to reference volume. The suggested cost function makes possible a more robust and accurate registration result than that of the cost function using the surface distance only. Also, this research provides an efficient means for image analysis through volume visualization of the registration result.
주요우울장애 환자에서 소뇌 국소 부위의 부피와 피질 두께의 차이
강지원,한규만,원은수,태우석,함병주,Kang, Ji-Won,Han, Kyu-Man,Won, Eunsoo,Tae, Woo-Suk,Ham, Byung-Joo 대한생물정신의학회 2018 생물정신의학 Vol.25 No.3
Objectives A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to investigate a difference in the volume and cortical thickness of the specific region of cerebellum between patients with MDD and healthy controls (HC). Methods A total of 127 patients with MDD and 105 HC participated in this study and underwent T1-weighted structural magnetic resonance imaging. We analyzed volume and cortical thickness of each twelve cerebellum regions divided by left and right and the volume and cortical thickness of the whole cerebellum from T1-weigted image of participants. One-way analysis of covariance was used to investigate the volume and cortical thickness difference of total and specific regions between two groups adjusting for age, gender, medication, and total intracranial cavity volume. Results We found that the patients with MDD had significantly greater volume in the left cerebellum lobule III region [false discovery rate (FDR)-corrected p = 0.034] compared to HC. Also, our findings indicate that cortical thickness of left lobule VIIB (FDR-corrected p = 0.032) and lobule VIIIB (FDR-corrected p = 0.032) are significantly thinner in the patients with MDD compared with the HC. No significant volume and cortical thickness differences were observed in other sub-regions of the cerebellum. The volumes and cortical thickness of whole cerebellum between patients with MDD and HC did not differ significantly. Conclusions We observed the region-specific volume and cortical thickness difference in cerebellum between the patients with MDD and HC. The results of our study implicate that the information about structural alterations in cerebellum with further replicative studies might provide a stepping stone toward a specific marker to diagnose MDD.
측두엽 간질에서 발작기 소뇌와 기저핵의 뇌혈류 변화 : SPECT 감영영상
신원철(Won Chul Shin),홍승봉(Seung Bong Hong),태우석(Woo Suk Tae),서대원(Dae Won Seo),김상은(Sang Eun Kim) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.1
N/A Purpose: The ictal perfusion patterns of cerebellum and basal ganglia have not been systematically investigated in patients with temporal lobe epilepsy (TLE). Their ictal perfusion patterns were analyzed in relation with temporal lobe and frontal lobe hyperperfusion during TLE seizures using SPECT subtraction. Materials and Methods: Thirty-three TLE patients had interictal and ictal SPECT, video-EEG monitoring, SPGR MRI, and SPECT subtraction with MRI co-registration. Results: The vermian cerebellar hyperperfusion (CH) was observed in 26 patients (78.8%) and hemispheric CH in 25 (75.8%). Compared to the side of epileptogenic temporal lobe, there were seven ipsilateral hemispheric CH (28.0%), fifteen contralateral hemispheric CH (60.0%) and three bilateral hemispheric CH (12.0%). CH was more frequently observed in patients with additional frontal hyperperfusion (14/15, 93.3%) than in patients without frontal hyperperfusion (11/18, 61.1%). The basal ganglia hyperperfusion (BGH) was seen in 11 of the 15 patients with frontotemporal hyperperfusion (73.3%) and 11 of the 18 with temporal hyperperfusion only (61.1%). In 17 patients with unilateral BGH, contralateral CH to the BGH was observed in 14 (82.5%) and ipsilateral CH to BGH in 2 (11.8%) and bilateral CH in 1 (5.9%). Conclusion: The cerebellar hyperperfusion and basal ganglia hyperperfusion during seizures of TLE can be contralateral, ipsilateral or bilateral to the seizure focus. The presence of additional frontal or basal ganglia hyperperfusion was more frequently associated with contralateral hemispheric CH to their sides. However, temporal lobe hyperperfusion appears to be related with both ipsilateral and contralateral hemispheric CH. (Korean J Nucl Med 2001;35:12-22)
부분적 간질에서 SPECT Subtraction을 이용한 발작 중 뇌혈류 변화에 대한 연구
이향운(Hyang Woon Lee),홍승봉(Seung Bong Hong),태우석(Woo Suk Tae),김상은(Sang Eun Kim),서대원(Dae Won Seo),정송철(Seung Cheol Jeong),이지영(Ji Young Yi),홍승철(Seung Chyul Hong) 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.3
N/A Purpose: To investigate the various ictal perfusion patterns and find the relationships between clinical factors and different perfusion patterns. Materials and Methods: lnterictal and ictal SPECT and SPECT subtraction were performed in 61 patients with partial epilepsy. Bath positive images showing ictal hypoperfusion and negative images revealing ictal hypoperfusion were obtained by SPECT subtraction. The ictal perfusion patterns of subtracted SPECT were classified into focal hypoperfusion, hypoperfusion-plus, combined hypoperfusion-hypoperfusion, and focal hypoperfusion only. Results: The concordance rates with epileptic focus were 91.8% in combined analysis of ictal hypoperfusion and hypoperfusion images of subtracted SPECT, 85.2% in hypoperfusion images only of subtracted SPECT, and 68.9% in conventional ictal SPECT analysis. Ictal hypoperfusion occurred less frequently in temporal lobe epilepsy (TLE) than extratemporal lobe epilepsy. Mesial temporal hypoperfusion alone was seen only in mesial TLE while lateral temporal hypoperfusion alone was observed only in neocortical TLE. Hippocampal sclerosis had much lower incidence of ictal hypoperfusion than any other pathology. Some patients showed ictal hypoperfusion at epileptic focus with ictal hypoperfusion in the neighboring brain regions where ictal discharges propagated. Conclusion: Hypoperfusion as well as hypoperfusion in ictal SPECT should be considered for localizing epileptic focus. Although the mechanisrn of ictal hypopertusion could be an intra-ictal early exhaustion of seizure focus or a steal phenomenon by the propagation of ictal discharges to adjacent brain areas, further study is needed to elucidate it. (Korean J Nucl Med 2000;34:169-82)
주은연,이은경,태우석,홍승봉 이화여자대학교 의과학연구소 2007 EMJ (Ewha medical journal) Vol.30 No.1
Objective : To present a normative database of hippocampus volume in Korean population. Methods : Seventy-two healthy volunteers(male 31, mean age 38.9years) were enrolled and underwent 1.6㎜ thickness whole brain SPGR(Spoiled Gradient Recovery) MRI. The volume of the hippocampus(HV) was calculated by the summation of the areas of all slices. The cerebrum, cerebellum and midbrain were included for the intracranial volume(ICV). Whole cerebral volume(WCV) and the ICV were calculated from multiplying total voxel count by the volume of one voxel. Subjects were all right-handed and divided into young age(15-49years, N=57) and old age group(58-83years, N=15). Mean HV, WCV, and ICV's were compared according to age, gender, and laterality. Results : Mean right HV(3350.8±368.4㎣) was significantly larger than left one(3104.3±365.8㎣) in all ages(p<.05). Women's HVs normalized to ICV in right and left sides were definitely larger than those of men although there was no difference of absolute HV between women and men. Mean WCV and ICV of men were significantly larger than those of women. Negative correlation was observed between the age and the HV, WCV, or ICV (p<.05). Conclusion : Our results showed that right HV was bigger than left one, and normalized HVs of women were larger than those of men. These findings provide normal database of HV in Korea and are important to detect unilateral or bilateral hippocampal atrophy m various brain diseases including epilepsy.