중증근무력증 환자의 말초 혈액내 T 림프구 분획의 변화

최철희,최인홍,김우경,선우일남,최철희 대한신경과학회 1998 대한신경과학회지 Vol.16 No.1

빛을 이용해 뇌로 약물 전달한다

최철희,Choe, Cheol-Hui 한국과학기술단체총연합회 2011 과학과 기술 Vol.506 No.-

장애아동의 심리치료를 위한 동물매개치료용 로봇

최철희,최병재,Choi, Chul-Hee,Choi, Byung-Jae 대한임베디드공학회 2009 대한임베디드공학회논문지 Vol.4 No.3

An animal assisted therapy (AAT) for handicapped child's psychotherapy has been reported by some researches. A robot can be substituted for the role of a real animal of the AAT. The robot for the AAT is called RAT (Robot Assisted Therapy). It consists of four parts: microprocessor-based MCU(Micro Control Unit), sensing part with various sensors, the movement part operated by some motors, and the exterior with soft feel. We will here introduce the RAT.

파킨슨 병에서 levodopa치료가 우울증에 미치는 영향

최철희,이준홍,손영호,김진수 대한신경과학회 1997 대한신경과학회지 Vol.15 No.4

Effect of Stimulus Rate and Gender on Auditory Brainstem Response in Korean Young Adults

최철희,Ki-Hyeon Jang,최성희 한국청각언어재활학회 2015 Audiology and Speech Research Vol.11 No.2

The main objective of this study was to determine the effect of stimulus rate and gender on auditory brainstem response (ABR) latency and amplitude in Korean young adults. A total of thirty young adults consisting of fifteen males and fifteen females participated in the study. We performed this study by analyzing the latencies and amplitudes of ABR wave I, Ⅲ, and V as a function of low stimulus rate and gender. The stimulus repetition rate was changed in five steps: 8, 16, 21, 32, and 64/s. Experimental results showed that when stimulus rates increased, significant differences in the latency and amplitude of wave I, Ⅲ, and V were observed while a gender effect was found on the latency of wave Ⅲ and the amplitudes of wave I and Ⅲ. As stimulus rates increased, the latencies of wave I, Ⅲ, and V consistently and progressively increased, whereas the amplitudes of ABR waves inconsistently changed. The latency shift became longer in wave V than wave I and Ⅲ. The amplitude of wave I, Ⅲ, and V was greatest at a stimulus rate of 21/s and least at a stimulus rate of 32/s, compared to those of other stimulus rates. This study will provide beneficial information in developing proper strategies that optimize and enhance the ABR wave latencies and amplitudes in different gender groups, saving the ABR test time in clinical applications, and establishing a quantitatively normative database for clinical purposes.

[논평] 장훈태 교수, 이만석 선교사의 발표에 대한 논평

최철희 기독교학술원 2015 영성포럼 Vol.24 No.1

Multiplex Analysis of Cytokines in the Serum and Cerebrospinal Fluid of Patients With Alzheimer’s Disease by Color-Coded Bead Technology

최철희,정지향,장중식,최경순,이중설,권종범,최경규,이종서,강상원 대한신경과학회 2008 Journal of Clinical Neurology Vol.4 No.2

Background and purpose: The availability and promise of effective treatments for neurodegenerative disorders are increasing the importance of early diagnosis. Having molecular and biochemical markers of Alzheimer’s disease (AD) would complement clinical approaches, and further the goals of early and accurate diagnosis. Combining multiple biomarkers in evaluations significantly increases the sensitivity and specificity of the biochemical tests. Methods: In this study, we used color-coded bead-based Luminex technology to test the potential of using chemokines and cytokines as biochemical markers of AD. We measured the levels of 22 chemokines and cytokines in the serum and cerebrospinal fluid (CSF) of 32 de novo patients (13 controls, 11 AD, and 8 Parkinson’s disease [PD]). Results: MCP-1 was the only cytokine detectable in CSF, and its levels did not differ between control and disease groups. However, the serum concentration of eotaxin was significantly higher in AD patients than in the control group. Conclusions: The analysis of multiple inflammatory mediators revealed marginal differences in their CSF and serum concentrations for the differential diagnosis of AD and PD. These results provide evidence that immunological responses are not major contributors to the pathogenesis of AD and PD.

Hearing Threshold Shift and Speech Intelligibility Index of Personal Hearing Protective Devices

최철희 한국청각언어재활학회 2013 Audiology and Speech Research Vol.9 No.1

The objective of this study is to investigate the effectiveness of the personal hearing protective devices in terms of the hearing threshold shift and the speech intelligibility index. The hearing threshold shift was used to quantify the protection effect of the personal hearing protective devices and obtained by subtracting the baseline threshold measured without the personal hearing protective devices from the hearing threshold measured with the personal hearing protective devices. The speech intelligibility index (SII) was used to predict and compare the potential benefits of each personal hearing protective device and obtained from the count-the dots method. A total of 6 college students aging from 21 to 25 years old were randomly recruited as subjects. Different types of personal hearing protective devices (earplug and earmuff) were used in this study. A statistically significant difference between the mean amount of threshold shift at low frequency (0.25-1 kHz) and that of high frequency region (2-8 kHz) was observed. The personal hearing protective devices (earplug and earmuff) were effective in protecting hearing from high frequency noises than low frequency noises. The use of earmuff was effective at the low frequency region while the use of earplug was effective at the high frequency region. In addition, the use of the earplug was more effective for the SII than that of the earmuff. The protection amount of the personal hearing protective devices (earplug and earmuff) ranged from 23 to 38 dB. However, the SII ranged from 32.6 to 54.5%, which indicates that the subjects misunderstood or missed the speech information ranged from 45.5 to 67.4% as mild to moderate hearing loss. This may lead to the development of new personal hearing protective devices which are effective for protecting hearing and understanding speech.

Therapeutic effect of combined antioxidant drugs (4-OHPBN plus NAC) on acute acoustic trauma in terms of distortion product otoacoustic emission

최철희 한국청각언어재활학회 2011 Audiology and Speech Research Vol.7 No.1

Acute acoustic trauma (AAT) induces hearing loss through the primary hair cell death pathway called apoptosis. The hair cell death occurs by over-production of reactive oxygen species, reactive nitrogen species, and other free radicals, which result from oxidative stress destroying the antioxidant defense mechanisms in the cochlea. Pharmacological approaches have been developed to prevent or treat cochlear damage induced by AAT. The objective of this study is to investigate the therapeutic effect of the combined antioxidant drugs (4-OHPBN plus NAC) in treating hearing loss induced by AAT when these drugs are orally administered. Thirty female chinchillas (six for each group) were exposed to a 105 dB SPL octave-band noise centered at 4 kHz for 6 hours. A combination of 4-hydroxy phenyl-N-tert-butylnitrone (4-OHPBN) plus N-acetyl-L-cystein (NAC) were orally administered to all experimental groups giving a first injection 4 hour after noise exposure and continually injecting twice daily for the next two days. Cubic distortion product otoacoustic emissions (DPOAE) before noise exposure and 21 days after noise exposure were obtained and statistically analyzed. The cubic DPOAE amplitudes were significantly different among different groups at different frequencies. The oral administration of 4-OHPBN plus NAC significantly increased permanent DPOAE amplitude. The increase was partially correlated with the dose of 4-OHPBN plus NAC. These results demonstrate that the combination of 4-OHPBN plus NAC can treat acute acoustic trauma although these drugs are orally administered. At the high dose of 4-OHPBN (75 mg/kg) plus NAC (200 mg/kg), the cubic DPOAE amplitude was reduced compared to those of 4-OHPBN (50 mg/kg) plus NAC (100 mg/kg). This reduction indicates that the only highest dose of 4-OHPBN may be ototoxic.

Mechanisms of Noise-Induced Hearing Loss and Treatment

최철희 한국청각언어재활학회 2011 Audiology and Speech Research Vol.7 No.2

Noise-induced hearing loss (NIHL) means hearing loss or cochlear damage induced by either a short exposure to an intense impulse sounds from 100 to 150 dB SPL or continuous exposure to loud sounds at or above 85 dB SPL over relatively long period of time. Noise exposure results in oxidative stress destroying the antioxidant defense mechanism in the cochlea by over-production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radicals. The purpose of this study is to explain the basic mechanisms of NIHL and to review a target and the site of action of treatment in terms of free radical formation. Oxidative stress begins immediately after noise exposure and continues up to 21 days after the exposure. Cell death process progresses after noise exposure. A primary cell death pathway following noise exposure is called apoptosis. Pharmacological approaches for prevention or treatment of NIHL have been developed with both oxygen-based antioxidant drugs inhibiting the generation of ROS and nitrogen-based antioxidant drugs inhibiting the production of RNS. There are synergistic effects of combined antioxidant drugs because each antioxidant drug may target different treatment mechanism. When one antioxidant drug was used in combination with other antioxidant drugs, the amount of reduction was analyzed and described. In addition, the optimal timing of therapeutic effects of antioxidant drugs depends on the time of initial treatment and the length of treatment before and after noise exposure. The maximal effect of treatment was observed in treatment for 9 days with injection starting at 24 h after noise exposure. The treatment of antioxidant drugs extending up to 10 days after noise exposure can reduce cumulative cochlear damage resulting from the delayed formation of free radicals. However, the relationship between free radical formation and the optimal timing of treatment is still unclear. Further studies on the relationship should be continually performed because of clinical usefulness and its importance.