Clinical manifestations of CNS infections caused by enterovirus type 71

최철순,강진한,Yun Jung Choi,Ui Yoon Choi,한지환,정대철,김현희,김종현 대한소아청소년과학회 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.1

Purpose: Enterovirus 71, one of the enteroviruses that are responsible for both hand-foot-and-mouth disease and herpangina, can cause neural injury. During periods of endemic spread of hand-foot-andmouth disease caused by enterovirus 71, CNS infections are also frequently diagnosed and may lead to increased complications from neural injury, as well as death. We present the results of our epidemiologic research on the clinical manifestations of children with CNS infections caused by enterovirus 71. Methods: The study group consisted of 42 patients admitted for CNS infection by enterovirus 71 between April 2009 and October 2009at the Department of Pediatrics of 5 major hospitals affiliated with the Catholic University of Korea. We retrospectively reviewed initial symptoms and laboratory findings on admission, the specimen from which enterovirus 71 was isolated, fever duration, admission period,treatment and progress, and complications. We compared aseptic meningitis patients with encephalitis patients. Results: Of the 42 patients (23 men, 19 women), hand-foot-and-mouth disease was most prevalent (n=39), followed by herpangina (n=3),upon initial clinical diagnosis. Among the 42 patients, 15 (35.7%) were classified as severe, while 27 (64.3%) were classified as mild. Factors such as age, fever duration, presence of seizure, and use of intravenous immunoglobulin (IVIG) were statistically different between the 2groups. Conclusion: Our results indicate that patients with severe infection caused by enterovirus 71 tended to be less than 3 years old, presented with at least 3 days of fever as well as seizure activity, and received IVIG treatment.

수의학과 의학의 불가분성 -수의미생물학이 의학에 미친 역사적고찰-

최철순,Choi Chul Soon 대한수의사회 1977 대한수의사회지 Vol.13 No.4

정상인(正常人) 혈청(血淸)의 Propionibacterium acnes Serotype I 및 Serotype II에 대한 항체(抗體)

최철순,서용열,양용태,Choi, Chul-S.,Seo, Yang-Y.,Yang, Yong-T. 대한미생물학회 1979 大韓微生物學會誌 Vol.14 No.1

Antibodies to Propionibacterium acnes(Corynebacterium parvum) serotype I and serotype II in normal human sera were measured using a microtitre bacterial agglutination test. Of 168 sera tested, 53 sera(31.0%) exhibited higher agglutinin titres to serotype I than to serotype II and 34 sera(20.2%) gave higher titers to serotype II than to serotype I. Eighty-one sera(48.3%), however, showed similar antibody titres to both types. Antibodies to serotype I(x) and serotype II(y) showed high correlation(r=0.73, p<0.01) and regression equation was Y=1,078+0.73X. The mean antibody titre($log_2$) of 529 normal sera(male 447 and female 82) to serotype I was $5.49{\pm}1.36$, but there was no significant difference between male($5.45{\pm}1.36$) and female($5.74{\pm}1.36$). Bacterial agglutinin to Propionibacterium acnes in normal sera belonged to a 2-mercaptoethanol resistant IgG class.

생물무기로 사용된 병원균과 질병에 대한 고찰

최철순,Choi Chul-soon 대한수의사회 2002 대한수의사회지 Vol.38 No.9

Recently, biological weapons (BWs) prepared with pathogenic microorganisms, toxins and biological vectors have been used maliciously for biological warfare, bioterrorism and/or agroterrorism by hostile countries and terrorists. In this review, historical background of disease and malicious use of BWs pathogenicity of microorganisms, advanced methodology involved in laboratory diagnosis, and prevention and control of anthrax (Bacillus anthracis), plague (Yersinia pseudotuberculosis subs. pestis), glanders (Burkholderia mallei), and smallpox (Variola virus) which have been abused for biological warfare or bioterrorism were discussed. In addition, the pathogenicity of microorganisms and the methodology needed to diagnose and control 6 diseases identified by WHO/CDC, ie., smallpox, inhalation anthrax, pneumonic plague, botulism, tularemia, and hemorrhagic fevers that would wreak havoc if terrorists successfully disseminated the germs by air were described.

Sensitivity of Repeat Tuberculin Test with Bovine PPD, Seibert's Fraction A (SFA) and Avian PPD Tuberculins in Visible and Non-visible Lesion Reactor Cattle to HCSM Tuberculin

최철순,김재학,윤용덕,Choi, Chul-soon,Kim, Jae-hak,Yoon, Yong-dhuk The Korean Society of Veterinary Science 1984 大韓獸醫學會誌 Vol.24 No.1

Tuberculin(HCSM) 반응유우 60두에 대하여 가열살균처리한 우결핵균에서 얻은 PPD-BS tuberculin을 이용한 추벽피내재검사법과 석탄산살균처리한 우결핵균에서 얻은 SFA tuberculin을 이용한 경측피내재검사법간의 민감성과 특이성을 비교하였다. 또한 SFA tuberculin과 현행 조형 PPD(PPD-A) tuberculin을 이용한 비교검사법의 가치를 판독기준에 따라 분석하였다. 병소우군에서 PPD-BS와 SFA tuberculin간에 민감성은 차이가 없었으나 무병소우와 감염우동거군에서 SFA tuberculin은 PPD-BS tuberculin에 비하여 비특이반응이 현저히 낮았다(P<0.01). SFA와 PPD-A를 이용한 비교검사법은 판독기준에 따라 가양성반응과 가음성반응에 크게 영향을 주었으며, 피내반응차이 4mm를 판독기준으로 할 때 병소우와 무병소우를 감별할 수 없었다. 이 연구에서 SFA tuberculin은 PPD-BS에 비하여 병소우에서 민감성간에는 차이가 없었으나 무병소우에서 특이성이 현저히 높았다는 점으로 보아 앞으로 HCSM tuberculin 반응우에 대한 재검사는 현행 PPD에서 SFA tuberculin으로 대체함으로써 비특이반응우를 더욱 감소시킬 수 있다는 것을 의미한다.

Detection of Specific Antibody to Mycobacterium tuberculosis in Anti-Complementary Human, Rabbit and Bovine Serum by Supplementation with Procomplementary Porcine Serum

최철순,양용태,Choi, Chul-Soon,Yang, Yong-Tae The Korea Society for Microbiology 1981 大韓微生物學會誌 Vol.16 No.1

보체결합반응은 감염초기의 항체검출에 대한 민감성이 높기 때문에 사람과 동물의 만성질환, 특히 매독, 브루셀라병. 결핵병, ?냑鵝뵉퓌鑿?, 클래미디아감염증, 마이코플라스마감염증, 콕시오이드병, 히스토플라스마병 등의 면역학적진단수기와 예방관리를 위한 전염병학적연구목적에 흔히 사용된다. 그러나 검사혈청이 항보체성 또는 친보체성을 갖는 경우는 특이항체를 검출할 수 없는 단점을 갖고 있다. 그러므로 이 연구에서는 친보체성분을 갖는 돼지혈청을 항보체성 사람, 토끼 및 소혈청에 보강하여 특이 항체검출을 위한 민감성과 특이성에 관한 기초실험을 실시하였다. 결핵에 감염된 사람, 토끼 및 소혈청중에 높은 항보체작용이 있는 혈청에 친보체성 돼지혈청을 보강할 때 결핵균(다당체 및 단백질항원)에 대한 특이항체가 검출되었다. A direct complement fixation test supplemented with procomplementary porcine serum was studied using anticomplementary human, rabbit and bovine serum against Mycobacterium tuberculosis. Procomplementary activity of porcine serum varied with porcine individual and affected by anticomplementary antiserum. The procomplementary titre of porcine serum against rabbit, human and bovine serum ranged from 1:5 to 1:40. By means of complement fixation test supplemented by porcine serum, the specific complement-fixing antibody to both tuberculopolysaccharide and/or tuberculoprotein antigen was readily differentiated from the anticomplementary antibody titre.

폐결핵 또는 유사폐결핵환자의 객담에서 분리된 Mycobacteria 제II군(암발색균)의 균종동정

최철순,신성수,정상인,양용태,김상재,배길한,Choi, Chul-Soon,Shin, Sung-Soo,Chung, Sang-In,Yang, Yong-Tae,Kim, Sang-Jae,Bai, Kill-Han 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1

Species of scotochromogenic mycobacteria of Group II isolated from sputa of patients with pulmonary tuberculosis and tuberculosis-like diseases from 1979 to 1984 were identified by simple biochemical tests using. nitrate reduction, Tween-80 hydrolysis, arylsulfatase and urease test, and serotypes of the isolates belonging to M. scrofulaceum were differentiated by bacterial agglutination test. Of 39 strains. tested, 11(28.2%) proved to be M. scrofulaceum, 15(38.5%) M. flavescens and 13(33.3%) M. gordonae. But none of the isolates belonged to M. szulgai and M. xenopi known as major pathogens of mycobacteria of Group II. Of 11 strains of the isolates identified as M. scrofulaceum 3 strains(27.3%) each belonged to serotype 41 and 42, and 4 strains(36.4%) belonged to serotype 43, but one strain was not typable because of its inagglutinability by any one of the type specific sera. In addition, the sensitivity and specificity of rabbit immune sera against type strains of serotype 41, 42 and 43 of M. scrofulaceum were analysed by bacterial agglutination test. In the sensitivity of microplate test with 11 isolates of M. scrofulaceum, a comparative tandem test using 2 units and one unit of absorbed antisera against three serotypes appeared to be superior to a conventional microplate test using one unit of type specific antisera.

Mycobacterium fortuitum-chelonei complex 및 신속발육 Mycobacteria 10개 균집합체의 거대집락형태

최철순,전호진,양용태,Choi, Chul-Soon,Jeon, Ho-Jin,Yang, Yong-Tae 대한미생물학회 1986 大韓微生物學會誌 Vol.21 No.3

We developed a giant colony test system with rapidly growing mycobacteria by stab-culture with a loopful inoculum of cells into Middlebrook 7H10 agar medium containing soluble extracts of the fruits of Gardenia jasminoides(7H10-crocin agar medium) and assessed the significance of the giant colony test with 28 strains of 10 clusters of rapidly growing mycobacteria classified by the simple biological 5-test characters. Of the 10 clusters of mycobacteria tested, some of strains which belonged to cluster No. 1a, 5a and 11a did grow as gravis types, whereas most of other clusters gave mitis or intermedius types in their colonial sizes at 12 days culture. By this test, pathogenic strains of M. fortuitum-chelonei complex which belonged to cluster No. 5a, b, 7a and 8a, b could be divided into gravis, intermedius and mitis colony types and the gravis ones were characterized by bluish-white "mushroom-shaped" colonies with central complexes in the texture, whereas the intermedius gave grayish-white "flower-shaped" colonies with radiated folds, but without any central complexes. The mitis colonies were characterized by grayish-white smooth or smooth mucoid colonies and were common among the clusters in their shapes. The colony of M. chelonei was bluish-white mitis type and was characterized by its hilly rhizoid colony. The gravis colony of cluster No. 1a identified as M. phlei was characterized by yellow "round straw- mat-shaped" or "chrysanthemum-shaped" colony with whole complexes in the texture, and the gravis colonies of the cluster No. 11a gave grayish-white "flower-shaped" colonies with central stamens, radiating trough and fine cup-shaped strands in the texture. The four colony types of pathogenic species of M. fortuitum-chelonei complex on 7H10-crocin agar medium were distinctive from those of other clusters of rapidly growing mycobacteria and these results indicated that the giant colony test, in conjunction with the simple 5-test characters, would be of value in the differentiation of M. fortuitum complex from other clusters of rapidly growing mycobacteria.

대지측량(大地測量)에 있어서 투영법(投影法)에 의한 좌표변환(座標變換)의 연구(硏究)

최철순,Choi, Chul Soon 대한토목학회 1985 대한토목학회논문집 Vol.5 No.2

The coordinates of triangulation stations which has been used in Korea, were computed by means of the Gauss Conformal Double Projection in the 1910's. This projection has been considered as a problem in respect of accuracy, because the farther a station is from the origin, the larger the computational error becomes. In this paper, the Gauss Conformal Double Projection is compared with the T.M(Transverse Metcator) Projection which is widely used in many countries. In T.M projection method more accurate ground coordinates are obtained. This paper has an objective to improve the accuracy of public surveying by using the method presented in this paper. 본(本) 연구(硏究)에서는 지금까지 이용해온 가우스 상사이중투영법(相似二重投影法)과 세계적으로 널리 사용되고 있는 횡(橫)메르카토르 투영법(投影法)을 비교분석(比較分析)함으로써 보다 정확한 대지측량좌표(大地測量座標)를 제시하여 공공측량(公共測量)의 정확도(正確度)향상 및 국가기준점(國家基準點)으로서의 역할을 다하고자 하는데 그 목적(目的)이 있다. 우리 나라는 1910년대에 조선총독부(朝鮮總督部)가 조선토지조사사업(朝鮮土地調査事業)의 일환으로 계획되고 시행한 삼각측량(三角測量)의 계산에 가우스 상사이중투영법(相似二重投影法)이 사용되었으나, 계산당시 수계산(手計算)에 의존하였으므로 계산상의 오차(誤差)가 포함되었을 뿐만 아니라 투영법(投影法)이 갖는 왜곡오차(歪曲誤差)도 포함되어 정확도면(正確度面)에서 문제가 되어 왔다. 따라서, 횡(橫)메르카토르 투영법(投影法)과 비교분석하여 오차분포(誤差分布)를 고찰하고 횡(橫)메르카토르 투영법(投影法)을 도입하여 삼각점좌표(三角點座標)를 계산할 경우 기대되는 오차(誤差) 향상도 및 공공측량(公共測量)의 계용오차범위(計容誤差範圍)를 고려한 원점(原點)의 적용범위를 비교분석하였다.

サッカー競技中ボールの移動スピードに關する分析

崔喆洵(Choi Chul-Soon) 한국체육과학회 2005 한국체육과학회지 Vol.14 No.1

Our study is to establish an analysis for movement of the ball and speed during soccer game for subject. During soccer game we divide a game into a quarter time for each team's ball keeping time and per ball keeping time, the speed of average. And we find that in each quarter, the team that has more ball's keeping time is more fast the speed of ball's speed of movement and it is able to use a standard of judgement that is team's superiority or inferiority for comparing speed of ball's movement per unit time of team. From this, we show that it is a new method of the analysis of team for ball and if the power of ball's speed is big, the team's power is same, too.