펠비낙 경피흡수 제제화 및 약제학적 평가

최정현,김재백,고건일,손동환 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1

Felbinac is an effective non-steroidal anti-inflammatory drug used topically for the treatment of sprains, strains and soft tissue injuries. The patch was prepared with an impermeable backing layer and an adhesive matrix using Primal^(??), Acrysol^(??), some enhancers, solvents and felbinac. A peel test of the patch showed variable peel strengths ranging from 160 to 550g/12mm(width) in differing compositions. The polysorbate 80 and HCO-40 had lessening effects with decreasing peel strengths. The drug release rate from the patch was more than 50% in 4 hours and approximately 100% in 12 hours. The patch contained enhancer, linoleic acid or oleic acid, showed increasing effect on the permeation rate through the hairless mouse skin in vitro. In another experiment, skin permeation from the patch was increased according to dose. In a pharmacokinetic study of the patch, T_(max) and C_(max) were respectively 9 hours and 78.6ng/ml. The AUC_(0-24h) was 1.38㎍·hr/ml. The felbinac patch displayed higher drug absorption compared to the ointment. In conclusion from the above results, it was considered that the felbinac patch was useful as a NSAIDs, more effective than oinment, avoiding systemic side-effects.

포스타 전시 발표 : 감염, 알레르기, 류마티스 ; 요근농양의 임상적 특징 및 결과 고찰

최정현,신승수,이규성,오윤정,최영화,박광주,황성철,이이형 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-

범슬라브주의의 프리즘으로 본 『안나 카레니나』

최정현 중앙대학교 외국학연구소 2011 외국학연구 Vol.- No.16

В данной статье рассматривается роман Л. Толстого "Анна Каренина" через призм панславизма. Последняя часть произведения автора отказыается публиковать в журнале "Русский вестник", где распечаталось до седьмой части, так как редактор данного журнала М. Н. Катков не согласился с содержанием романа. Он стал неудоблетворителен отношением Л. Толстого к панславизму, в частности в 70-е годы в России, когда Россия приняла участие в войне против Турции для осбовождения сербского народа. Лев Толстой очень критически относился к этому движению того времени, но в своем романе Толстой только литературныйм образом подходил к данной сложной проблеме. Об этом автор этих сторчек хотелось бы остановиься. a

자세교정을 위한 체위변환 감지 센서 디바이스의 정확성 평가

최정현,박준호,강민호,서재용,김수찬 한국융합신호처리학회 2021 융합신호처리학회 논문지 (JISPS) Vol.22 No.3

Recently Recently, the incidence of spinal diseases due to poor posture among students and office workers is increasing, and various studies have been conducted to help maintain correct posture. In previous studies, a membrane sensor or a pressure sensor was placed on the seat cushion to see the weight bias, or a sensor that restrained the user was attached to measure the position change. In our previous study, we developed a sensor device which can be easily attached to the body with an adhesive gel sheet and that measures and outputs the user's posture and body position in real time, but it has a limitation in the accuracy of the sensor value. In this study, a study was conducted to improve the performance of the position conversion sensor device and quantitatively evaluate the accuracy of the angle conversion measurement value, and a high accuracy with 2.53% of error rate was confirmed. In future research, it is considered that additional research targeting actual users is needed by diversifying posture correction training contents with multimedia elements added. 최근 학생 및 사무직 종사자의 자세 불량으로 인한 척추계 질환의 발병율이 증가하고 있으며, 바른 자세 유지를 돕기 위한 다양한 연구가 수행되었다. 기존 연구에서는 의자 방석부분에 멤브레인 센서 또는 압력센서를 배치하여 무게의 편중을 보거나, 사용자를 구속하는 센서를 부착하여 체위변환을 측정하였다. 본 연구자는 선행연구에서 점착성 겔시트로 간편히 몸에 부착할 수 있으며, 사용자의 자세 및 체위 변화를 실시간으로 측정하여 출력하는 센서 디바이스를 개발하였으나 센서값의 정확성에서 한계점을 보였다. 본 연구에서는 체위변환 센서 디바이스의 성능을 개선하고, 각도변환 측정값의 정확도를 정량적으로 평가하는 연구를 수행하였으며, 오차율 2.53%의 높은 정확도를 확인하였다. 향후 연구에서는 멀티미디어 요소가 추가된 자세교정 훈련 컨텐츠를 보다 다양화하여 실제 사용자를 대상으로 하는 추가 연구가 필요한 것으로 사료된다.

국내 감염증의 항생제 치료 : 발열성 호중구 감소증의 치료

최정현 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.2

청소년의 인지능력 훈련을 위한 운동-학습 시스템의 개발

최정현,박준호,윤지숙,서재용,박찬홍,Choi, Jung-Hyeon,Park, Jun-Ho,Yoon, Ji-Sook,Seo, Jae-Yong,Pakr, Chan-Hong 한국융합신호처리학회 2020 융합신호처리학회 논문지 (JISPS) Vol.21 No.3

With the importance of creative learning highly valued, the demand for education in early childhood and adolescence has been increasing in recent years, but simple memorization-oriented and classical teaching methods tend not to prove high effectiveness in terms of learner-centeredness. Students who study static at their desks for a long time do not prefer boring classical learning methods, and there is also a lack of educational methods and educational content that conforms to the convergence education trend in the actual educational field. Therefore, this study has created a system that allows students to exercise and learn at the same time through a fun and familiar approach, and implement educational content through activation of brain plasticity. 최근 교육현장 및 가정에서는 창의적 학습의 중요성이 높게 평가되면서 유아 및 청소년기 아동의 교육 수요가 증가하고 있지만, 단순한 암기교육 위주와 고전적인 교육방식은 학습자 중심적 측면에서 효과가 크지 않은 경우가 많다. 오랫동안 책상에 앉아 있는 학생들은 지루한 고전적인 학습방법을 선호하지 않으며, 현재 교육 현장에서도 융합 교육 트렌드에 부응하는 교육 방법 및 교육 콘텐츠가 부족한 것이 현실이다. 따라서 본 연구에서는 학생들이 재미있고 친숙한 접근방법을 통해 운동을 병행하며 학습할 수 있으며, 뇌 가소성(brain plasticity) 활성화를 통해 교육 콘텐츠를 구현할 수 있는 시스템을 만들었다.

청소년의 자아존중감과 공동체의식에 관한 종단적 융합연구 -한국아동·청소년패널조사를 중심으로-

최정현 중소기업융합학회 2019 융합정보논문지 Vol.9 No.12

The study used cross-lagged path modeling to examine the longitudinal associations between self-esteem and community spirit among adolescents. This is a longitudinal study designed to examine the developmental changes of adolescents’ self-esteem and community spirit in Korea. This study used the data collected by the Korean Children and Youth Panel Survey (KCYPS) from 2014 through 2016. Participants were surveyed from the 5th grade to the 7th, which belonged to the 1st elementary school cohort panel of the KCYPS. To be used as the data of this study, children should have all information at 3-time points: the 5th grade; 6th grade; 7th grade. The collected data were analyzed with PSAW 18.0 and AMOS statistical program. The participants in this study were 903 males (51.6%) and 847 females (48.4%). The level of self-esteem was 3.29±.51, 3.19±.55, and 3.15±.57 point at 5th grade, 6th grade, and 7th grade each. The level of community spirit was 3.12±.52, 3.09±.59, 3.15±.55 point respectively. Community spirit from elementary school to middle school is consistently predicted by previous self-esteem. Likewise self-esteem has a significant predictive effect on subsequent community spirit. 본 연구는 초등학생의 자아존중감과 공동체의식간의 인과적 관계를 검증하는데 있다. 초등학생이 성장함에 따라 자아존중감과 공동체의식과의 변화정도와 관련성을 파악하기 위해 종단적인 자료를 이용하였다. 이를 위해 한국아동·청소년패널조사(KCYPS)의 초1 패널 자료 중 5차, 6차 7차년도의 종단 자료를 활용하여 청소년의 자아존중감과 공동체의식 사이의 종단적 상호관계를 자기회귀교차지연모형(autoregressive crosslagged model)을 통해 알아보고자 하였다. 자료는 PSAW 18.0와 AMOS를 이용하였다. 본 연구의 대상자는 총 1750명으로 남자가 903명(51.6%), 여자는 847명(48.4%)이다. 초등학교 5학년, 초등학교 6학년, 중학교 1학년의 자아존중감의 평균은 3.29±.51, 3.19±.55, 그리고 3.15±.57이었다. 공동체의식의 평균은 3.12±.52, 3.09±.59, 그리고 3.15±.55이었다. 자기회귀교차지연모형을 통한 분석결과 초등학교 5학년부터 중학교 1학년까지 자아존중감과 공동체의식은 안정적으로 지속되었다. 또한 이전 시점의 자아존중감은 이후 시점의 공동체의식에 유의한 영향을 미치는 것으로 나타났다. 마찬가지로 이전시점의 공동체의식은 이후 시점의 자아존중감에에 영향을 미치는 것으로 나타났다.

호중구감소성 발열 환자의 경험적 치료 지침

최정현 대한종양외과학회 2010 대한임상종양학회 학술대회지 Vol.2010 No.3

Reduction of Entrance Surface Dose Depending on Shielding Methods for Panoramagraphy

최정현,김성철,한동균 대한방사선과학회 2015 방사선기술과학 Vol.38 No.3

Panoramagraphy was the second most used intraoral radiography utilized in Korea, resulting in 17.8% in university dental hospitals, 24.8% in dental hospitals, and 31.4% in dental clinics. Depending on increased demand like orthodontics and implant, panoromagraphy tends to consistently increase.This study were used lead glasses and lead shielding to reduce unnecessary radiation to the eyeballs and thyroid. ESD was 41.4% when radiation was shielded with the lead glasses while reducing 47.3% of ESD by shielding the X-ray tube area with shielding lead. There was no statistically significant difference. The lead glasses is appropriated to reduce unnecessary radiation exposure to the eyeballs.

Effects of Pilates and Tai Chi on Pain and Dysfunction in Chronic Lumbago Patients

최정현,황현숙 국제물리치료연구학회 2016 Journal of International Academy of Physical Ther Vol.7 No.1

The purpose of this study was to identify the effects of Pilates and Tai Chi as physical therapy interventions for pain and dysfunction in chronic lumbago patients. A total of 31 females who were at least 20 years old and diagnosed with chronic lumbago were divided into a Pilates group(PG) (n=10), Tai Chi group(TCG)(n=11), and conservative group(CG)(n=10), to measure their pain and dysfunction before and after a six week intervention. With regard to the changes in the lumbago consciousness scale before and after the six-week intervention, all three groups showed statistical significance(p<.05). The intergroup differences were significant between the PG and CG and between the TCG and CG. All three groups also showed statistical significance(p<.05) in the Oswestry Disability Index before and after the six-week intervention. Again, the intergroup differences were significant between the PG and CG and between the TCG and CG. Based on these results, the application of Pilates and Tai Chi with conservative treatment may be effective in reducing pain and improving dysfunction in chronic lumbago patients.