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김병각(Byong-Kak Kim),정경수(Kyeong-Soo Chung),최응칠(Eung-Chil Choi),김혜령(Hye-Ryung Kim),박희주(Hee-Ju Park),조필형(Pil-Hyoung Cho) 한국생약학회 1983 생약학회지 Vol.14 No.3
To examine effects of oriental pharmaceutical preparations on immunity, four of such preparations which are currently being used were examined. After their fluid extracts were injected intraperitoneally to ICR mice, the counts of total cell number, PMN and macrophage in the peritoneal cavity were made by using non-specific esterase staining method, and plaque-forming cells (PFC) were measured by using the modified method of Cunningham and Jerne. The results showed that Bo-Jung-Ik-Ki-Tang, Ih-Jung-Tang, Ohn-Kyeong-Tang and Ke-Ji-Bok-Ryeong-Hwan-Ka-Dae-Hwang increased both the macrophages and the total cells of the peritoneal cavity and that these preparations increased the number of PFC in the spleen. Therefore the data indicate that they potentiate both of the cell-mediated and humoral immunities in the mice.
김숙희(Sook Hee Kim),김진숙(Jin Sook Kim),진미림(Mi Rim Jin),김하원(Ha Won Kim),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1994 생약학회지 Vol.24 No.4
To find antitumor components from higher fungi, the mycelia of Collybia confluens (Pers. ex Fr.) Kummer were cultured in artificial media. For efficient production of the mycelia, the influences of various modifications of culture conditions were examined. A water-soluble protein-bound polysaccharide fraction, Fr. A, was obtained from the mycelia by hot water extraction. When Fr. A was purified and fractionated by DEAE-cellulose and Sephadex G-200 gel filtration chromatographies into four fractions which were designated B, C, C-I and C-II. The tumor inhibition ratios of these fractions ranged from 46% to 75%, against the solid forms of sarcoma 180 in ICR mice at doses of 20 and 50 ㎎/㎏/day when given intraperitoneally. Especially, Fr. C which was named Collyban(CB) exhibited a marked life-prolonging effect of the mice against ascitic forms of sarcoma 180 at a dose of 50 ㎎ via i.p. administration. To extend spectra of the antitumor activities and eliminate the effects of allograft rejection, the characterization of antitumor effects of CB was performed in syngeneic host-tumor systems. It did not show any antitumor activity against L1210 murine leukemia in CD2F1 mice but prolonged their life span against ascitic forms of MM46 carcinoma in C3H/He mice. Also it exhibited antitumor activity against human cervical cancer HeLa cells that were xenografted into nude mice having BALB/c genetic backgrounds by the i.p. injection at a dose of 100 ㎎/㎏/day. In order to characterize the antitumor components, CB was examined by chemical analysis. It was acidic protein-bound polysaccharides composed of 31% polysaccharide, 27% protein and 3% hexosamine. CB was fractionated into two fractions, Fr. C-I(M.W.: 500 Kd) and Fr. C-II (M. W.: 30 and 8 Kd) by Sephadex G-200 gel filtration chromatography.
최응칠(Eung Chil Choi),김병각(Byong Kak Kim),정경수(Kyeong Soo Chung) 대한약학회 1988 약학회지 Vol.32 No.5
394 strains of soil microorganism were isolated from the Korean soil samples. The isolated strains were shake-cultured in oat-meal medium. The filtrates of the cultures were screened for the production of alpha-amylase inhibitors. Five strains were identified to produce alpha-amylase inhibitors. And these strains were identified as Actinomycetes.
리팜피신에 내성인 Streptococcus faecalis 균주의 개발
최응칠(Eung Chil Choi),김승호(Seung Ho Kim),권애란(Ae Ran Kwon),이미정(Mi Jeong Lee),오정자(Jeong Ja Oh),김병각(Byong Kak Kim) 대한약학회 1993 약학회지 Vol.37 No.4
The preparation of Streptococcus faecalis RSI is used as a medicinal preparation for human intestinal disorders. But the microbe in this preparation is very sensitive to rifampicin. If this preparation is taken with rifampicin, its therapeutic effect can not be expected. To develope rifampicin resistant mutants, the rifampicin sensitive strain S. faecalis RSI was treated with N-methyl-N''-nitro-N-nitrosoguanidine(MNNG). Twelve strains of the MNNG-induced mutants showed distinct resistance to rifampicin and five mutants were selected for further studies. They also exhibited identical characteristics with the parent S. faecalis RSI when they were tested for lactic acid formation and growth inhibition of E. coli. From in vitro test, it was identified that rifampicin is not inactivated by certain factors of the rifampicin resistant mutants. Conclusively, the rifampicin resistant mutants are efficient strains that have insensitivity against rifampicin and original biochemical characteristics of the parent strain.
한국산 고등균류의 성분 연구(Ⅳ) : Lactarius Piperatus (Fr.) S.F. Gray로 부터 Gultorin 의 분리
최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1975 생약학회지 Vol.6 No.1
In order to isolate constituents of Lactarius piperatus(FR.) S.F. GRAY, the fresh carpophore was homogenized with ethanol in a blendor, stored for three years and subsequently extracted with ethanol. From the concentrated ethanol solution, a mixture of compounds was precipitated, from which a white needle crystal, named gultorin, (mp.160∼162°) was obtained. The physical and chemical characteristics of gultorin were determined.