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한국산 옻나무로부터 추출.분리한 생리활성 물질들의 항산화 효과 및 세포독성
최원식,김동길,이영행,김장억,이성은,Choi, Won-Sik,Kim, Dong-Kil,Lee, Young-Haeng,Kim, Jang-Eok,Lee, Sung-Eun 한국응용생명화학회 2002 한국농화학회지 Vol.45 No.3
한국산 옻나무의 메탄올추출물과 유기용매 분획의 항산화 효과를 조사하였다. 항산화 효과는 수소공여 억제능, 과산화지질 형성 억제능, xanthine oxidase저해 활성과 아질산염 소거능으로 측정한 결과, ethyl acetate 분획이 가장 뛰어난 효과를 나타내었다. 이 분획의 생리활성 물질을 분리하기 위하여, rotatory locular counter current chromatography(RLCCC), Sephadex LH-20 column chromatograpy와 HPLC등의 방법을 사용하여, 1,2,3-trihydroxybenzene, methyl 3,4,5-trihydroxybenzoat와 3,4,5-trihydroxybenzoic acid를 분리하였다. 이중 methyl 3,4,5-trihydroxybenzoate는 butylated hydroxyanisole(BHA)이나 butylated hydroxytoluene(BHT)보다도 강한 항산화 효과를 나타내었다. 그러나 세포독성 실험에서는 이들 물질들이 암세포주에 대하여 활성이 높지 않았다. 이상의 결과로 methyl 3,4,5-trihydroxybenzoate은 뛰어난 항산화 효과를 지닌 식품첨가물로서의 이용 가능성을 제시할 수 있다. Antioxidative activities of solvent fractions obtained from Korean Rhus vernicifera, being used in food industry and as a traditional medicine, were examined by the methods of DPPH scavenging activity, inhibitory effect on autooxidation of linoleic acid, nitrite scavenging activity and the inhibitory effect on xanthine oxidase activity. Ethyl acetate fraction showed potent antioxidative activities. Three compounds were isolated from the ethyl acetate fraction by rotatory locular counter current chromatography (RLCCC), Sephadex LH-20 column chromatography and HPLC. The isolated compounds were 1,2,3-trihydroxybezene, methyl 3,4,5-trihydroxybenzoate and 3,4,5-trihydroxybenzoic acid determined by GC/MS and, $^1H$ and $^{13}C$ NMR. Among the isolated compounds, methyl 3,4,5-trihydroxybenzoate showed the strongest antioxidative activity than artificial antioxidants, BHA and BHT in various methods. However, these isolated compounds did not show cytotoxicity effects on the human cancer cell lines. Therefore, we may suggest that methyl 3,4,5-trihydroxybenzoate can be used as a food additive possessing the potent antioxidative activity.
선박엔진의 Supply Unit용 SNCM420H의 절삭특성
최원식,성봉수,강창원,문희준,권주리,Choi, Won-Sik,Sung, Bong-Soo,Kang, Chang-Won,Mun, Hee-Joon,Kwon, Ju-Ri 한국생산제조학회 2010 한국생산제조학회지 Vol.25 No.5
SNCM420 steel is one of the cam shaft materials which are used in the supply unit for ship engine cam shaft. In this study the assessment of cutting behavior was conducted for the SNCM 420 steel and SM45C steel with various cutting conditions as depth of cut 0.5, 1.0, 1.5, 2.0mm and feed rate 0.1~0.3m/rev. The controlled chip was produced in feed rate 0.2, depth of cut 1.0 for SNCM420 and feed rate 0.2, depth of cut 2.0 for SM45C. There is no difference cutting force between SM45C and SNCM420 steels.
6${\beta}$-Bromopenicillanate로부터 6-(Carboxymethylthio) penicillanic Acid 유도체의 합성
최원식,이영행,이채호,Won-Sik Choi,Young-Haeng Lee,Chai-Ho Lee 대한화학회 1991 대한화학회지 Vol.35 No.5
6${\beta}$-bromopenicillanic acid(4a)와 p-nitrobenzylbromide, 3-bromophthalide, chloromethylpivalate 및 1-chlorodiethylcarbonate의 반응으로 6${\beta}$-bromopenicillanates(4b~4e)을 합성하였으며, 6${\beta}$-bromopenicillanic acid(4a)와 그의 ester(4b~4e)를 thioglycolic acid와 친핵성 치환반응시켜 새로운 $\beta$-lactam계 화합물인 6-(carboxymethylthio)penicillanic acid(5a)와 그의 ester(5b~5e)를 얻었다. Reaction of 6${\beta}$-bromopenicillanic acid(4a) with p-nitrobenzylbromide, 3-bromophthalide, chloromethylpivalate and 1-chlorodiethylcarbonate afforded 6${\beta}$-bromopenicillanates(4b~4e). New ${\beta}$-lactam compound, 6-(carboxymethylthio)penicillanic acid(5a) and the other esters(5b~5e) were prepared by nucleophilic substitution reaction of 6${\beta}$-bromopenicillanic acid(4a) and the other esters(4b~4e) with thioglycolic acid.
Tribological Characteristics in $40{\mu}m$ Dimple Pattern for Hexagonal Array
최원식,채영훈,Choi, Won-Sik,Chae, Young-Hoon,Umehara, Noritsugu Korean Tribology Society 2009 한국트라이볼로지학회지 (Tribol. Lubr.) Vol.17 No.5
본 연구에서는 pin-on-disk 마찰 시험기를 통하여 Hexagonal 배열 $40{\mu}m$ Dimple 패턴의 효과를 실험하였다. 마찰 실험은 미끄럼 속도가 $0.06{\sim}0.34m/s$로 하였으며 마찰하중은 $20{\sim}100\;N$의 범위로 하였고, Dimple의 밀도는 $10{\sim}25%$의 범위로 제작하여 실험을 행하였다. 일반적으로 속도가 증가하고 하중이 감소할수록 마찰계수는 감소하는 경향을 나타내었으며, Dimple에 의한 마찰저감 효과는 속도가 $0.14{\sim}0.26m/s$의 범위에서 나타났다. $40{\mu}m$ Hexagonal 배열 Dimple 패턴의 마찰 특성에서는 밀도가 12.5%에서 가장 좋은 경향을 나타내었다.
Friction Characteristics of CNx Coated Dimple Pattern with Hexagonal Array
최원식,Choi, Won-Sik,Umehara, Noritsugu Korean Tribology Society 2011 한국윤활학회지(윤활학회지) Vol.15 No.3
In this study, we examined the friction characteristics of a dimple pattern on a carbon nitride coating. The study was conducted with a hexagonal array 40 ${\mu}m$ dimple pattern on a steel bearing containing a CNx coating. The area density of the dimple patterns were varied between 5% and 25%, the speed was varied from 0.06-0.26 m/s, and the load was varied between 20-100N. In general, we found that as the velocity increased, the friction coefficient increased. Furthermore, the friction coefficient was lowest at a load of 40N. The friction coefficient of the non-coated specimen was 0.025-0.15; on the other hand, the friction coefficient of the coated specimen was 0.002-0.02. Thus, we determined that the coated materials could reduce the friction coefficient by a factor of 7.5.
최원식(Won-Sik Choi),김원구(Won-Ku Kim) 한국기계가공학회 2008 한국기계가공학회지 Vol.7 No.3
In this study, to examine the friction coefficient and wear amount of dental prosthesis, pin-on-disk type wear test were at room temperature. Vickers hardness and fracture toughness measurement of dental materials were preformed. Microscopic observations on worn surfaces of specimens were conducted by SEM. The friction coefficient of dental material was investigated according to weight and slinging velocity. dental material have investigated composed to nature teeth.
Tribological Charateristics in 40 ㎛ Dimple Pattern for Hexagonal Array
Won Sik Choi(최원식),Young Hoon Chae(채영훈),Noritsugu Umehara 한국트라이볼로지학회 2009 한국트라이볼로지학회지 (Tribol. Lubr.) Vol.25 No.1
본 연구에서는 pin-an-disk 마찰 시험기를 통하여 Hexagonal 배열 40㎛ Dimple 패턴의 효과를 실험하였다. 마찰 실험은 미끄럼 속도가 0.06~0.34 m/s로 하였으며 마찰하중은 20~100 N의 범위로 하였고, Dimple의 밀도는 10~25%의 범위로 제작하여 실험을 행하였다. 일반적으로 속도가 증가하고 하중이 감소할수록 마찰계수는 감소하는 경향을 나타내었으며, Dimple애 의한 마찰저감 효과는 속도가 0.14~0.26 m/s의 범위에서 나타났다. 40㎛ Hexagonal 배열 Dimple 패턴의 마찰 특성에 서는 밀도가 12.5%에서 가장 좋은 경향을 나타내었다.
최원식(Won-Sik Choi),박나람(Na-Ram Park),이창주(Chang-Ju Lee) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.- No.-
본 논문에서는 PVC의 재료의 절삭유의 유무에 따른 드릴링 특성 및 칩의 관찰을 통하여 최적의 재 료 가공방법을 알아보고자 한다.
인진쑥 배지에서 배양한 노루궁뎅이버섯 균사체 추출물(HEAC)의 알코올 대사촉진 활성
최원식(Choi, Won-Sik),장도연(Jang, Do-Yoen),차경민(Cha, Kyung-Min),박천규(Park, Chun-Kyu) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.1
인진쑥 배지에서 배양한 노루궁뎅이버섯(HEAC), 노루궁뎅이버섯과 인진쑥 추출물들의 음주 후 체내 알코올 농도의 감소 효과를 확인하였으며, 또한 혈중 알코올 탈수소효소 및 아세트알데히드 탈수소효소의 활성을 조사하여 알코올 분해 활성을 조사하였다. 체내 알코올 농도 측정결과 HEAC의 경우 170분, 노루궁뎅이 버섯 추출물은 210 분후에 혈중 알코올이 검출되지 않았다. 또한, HEAC는 알코올 탈수소효소 활성에서 대조군 보다 시간에 따라 154%, 노루궁뎅이버섯 추출물은 148%로 비교적 높은 활성을 나타내었다. 아세트알데히드 탈수소활성에서는 HEAC와 노루궁뎅이버섯 추출붙이 대조구에 비해 104~111%이상의 효소활성이 유지되는 것을 확인하였으며 이들 추출물들은 알코올 분해 촉진작용이 매우 우수함을 알았다. Alcohol concentration in the blood was effectively decreased by extracts from Hericium erinaceum hypha cultivated with Artermisia capillaris medium(HEAC), Hericium erinaceum hypha and Artermisia capillaris after dirnking. Also, the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase in the blood was studied. As a result of testing an alcohol concentration in the blood, the alcohol in the blood was not detected after 170 min. in case of HEAC and after 210 min. in case of Hericium erinaceum. Compared to control, each activities of alcohol dehydrogenase of HEAC and Hericium erinaceum hypha was showed up to 154% and 148% respectively. The activities of the acetaldehyde dehydrogenase of both extracts from HEAC and Hericium erinaceum was maintained in the range of 104 to 110% compared to control. In conclusion, such extracts represent significant effect to facilitate decomposition of alcohol.