내구 해석 정합성 향상을 위한 아크 용접부 해석 수명 도출

최문석,김동철 대한기계학회 2024 대한기계학회 춘추학술대회 Vol.2024 No.5

간의 염증성 국소 병변

최문석 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.1(S)

A variety of focal inflammatory lesions may present clinically with symptoms or may be noted incidentally during imaging evaluation for other clinical indication or routine check-up. Among them, eosinophilic liver abscess and inflammatory pseudotumor of the liver are noteworthy. Eosinophilic liver abscess is a disease with focal eosinophilic infiltration and microabscess formation in the liver. It is associated with low attenuation liver mass, a history of intaking raw meat or fish, peripheral eosinophilia. Inflammatory pseudotumor is a rare disease involving diverse organs such as lung, liver, stomach, and soft tissue. It consists of a fibrovascular stroma infiltrated with inflammatory cells, especially plasma cells. Although its pathophysiology remains uncertain, infection or abnormal reaction to infection is suggested as a cause of inflammatory pseudotumor of the liver. Histologic confirmation is warranted to avoid unnecessary operation.

C형 만성간염의 진단과 치료 전략 : 간이식과 C형간염

최문석 대한간학회 2004 추계 학술대회 Vol.10 No.-

C형 만성간염의 진단과 치료 전략 : 간이식과 C형 간염

최문석 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.4(S)

성인에서 참고구간 내의 혈중 Gamma-glutamyltransferase 농도에 따른 대사증후군 및 제2형 당뇨병 발병률과의 관련성

최문석,배태원,이재현,조용곤,이혜수,최삼임,김달식 대한진단검사의학회 2013 Laboratory Medicine Online Vol.3 No.1

Background: This study was conducted to establish reference intervals (RIs) for serum gamma-glutamyltransferase (GGT), and to evaluate the association between serum GGT levels within RIs and the prevalence of metabolic syndrome (MetS) and type 2 diabetes mellitus (DM) in men and women. Methods: A total of 363 healthy adults (137 men and 226 women) were enrolled for establishing the RIs of serum GGT. A cross-sectional study was conducted with 919 individuals (519 men and 400 women) to evaluate the associations between gender-specific serum GGT RI quartiles and prevalence of MetS and DM. Results: The RIs for serum GGT levels (central 95th percentile ranges) were 9.0-70.6 IU/L and 4.0-31.3 IU/L in men and women, respectively. In men, the odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of MetS in 4 serum GGT quartiles (lowest to highest) were 1.0 (reference), 3.6 (0.7-18.0), 8.8 (2.0-39.1), and 17.4 (4.0-75.3), respectively, while the ORs (95% CIs) for the prevalence of DM were 1.0 (reference), 1.0 (0.3-3.0), 1.7 (0.6-4.6), and 2.6 (1.0-6.6), respectively. In women, the corresponding ORs (95% CIs) were 1.0 (reference), 3.3 (0.6-16.6), 5.8 (1.2-27.3), and 18.8 (4.3-82.2) for MetS, respectively, and 1.0 (reference), 1.6 (0.3-9.7), 1.6 (0.3-9.9), and 8.0 (1.7-36.7) for DM, respectively. These significant relationships persisted after adjusting for age, alcohol intake, body mass index, and smoking. Conclusions: Serum GGT levels, even within RIs, were proportionally associated with prevalence of metabolic syndrome and DM in both men and women. Serum GGT level may be an independent predictor for chronic degenerative diseases. 배경: 본 연구에서는 건강한 성인에서 혈중 GGT 농도의 참고구간을 설정하고, 참고구간 내의 혈중 GGT 농도에 따른 대사증후군 및제2형 당뇨병 발병률과의 연관성을 분석하고자 하였다. 방법: 혈중 GGT 농도의 참고구간의 설정을 위해 총 363명(남자137명, 여자 226명)의 건강한 성인을 대상으로 하였다. 2011년 3월부터 10월까지 한 대학병원의 건강증진센터를 방문하여 본 연구에 동의하고 건강검진을 실시한 총 919명(남자 519명, 여자 400명)을 대상으로 단면조사연구를 시행하였다. 남자와 여자의 혈중GGT 농도의 참고구간을 4군으로 나누어 대사증후군과 제2형 당뇨병의 발병률의 관련성을 분석하였다. 결과: 중앙 95백분위수에 의한 혈중 GGT 농도의 참고구간은 남자에서 9.0-70.6 IU/L 그리고 여자에서 4.0-31.3 IU/L였다. 참고구간 내의 혈중 GGT 농도의 사분위수군에 따른 대사증후군 유병률의 대응 위험도(95% CI)는 남자와 여자에서 각각 1.0, 3.6 (0.7-18.0), 8.8(2.0-39.1), 17.4 (4.0-75.3)와 1.0, 3.3 (0.6-16.6), 5.8 (1.2-27.3), 18.8(4.3-82.2)였고, 제2형 당뇨병에 대해서는 각각 1.0, 1.0 (0.3-3.0), 1.7(0.6-4.6), 2.6 (1.0-6.6)과 1.0, 1.6 (0.3-9.7), 1.6 (0.3-9.9), 8.0 (1.7-36.7)였다. 이러한 연관성은 나이, 알코올 섭취, BMI 및 흡연유무로 보정한 후에도 유지되었다. 결론: 혈중 GGT 농도는 참고구간내의 농도라 할지라도 대사증후군 및 제2형 당뇨병의 발병률과 용량-반응관계의 연관성을 나타냈다. 따라서 혈중 GGT 농도는 만성퇴행성질환에 대해 하나의 독립적 예측인자가 될 수 있을 것이다.

우리나라 B형 및 C형 바이러스성 간견병증 환자에서의 간세포암 발생률의 비교에 대한 전향적 연구

최문석,이효석,이준행,김정룡 대한간학회 1996 Clinical and Molecular Hepatology(대한간학회지) Vol.2 No.1

Objectives:patients with HCV-associated liver cirrhosis had greater risk of hepatocellular carcinoma(HCC) than patients with HRV-associated in areas pirevalent for HCV infection. However, the relative risks of. HBV and HCV for HCC have not been investgated in an HBV-endemic area. The piresent study was designed to study prospectively the relative risk of HBV and HCV for HCC In korea. An HBV- endemic, area. Methods: We enrolled 373 patien ts with liver ciirrhosis who had experienced thc esophageal variccal bleeding and had been treated by endoscopic injection sclerothenpy, and survived more than ) 3 months. They were devided into three grourp 1) 245( 65.7%) patients who were positive for HBsAg but nagative for anti- HCV were in HBV group 2) 48 (l2.9'% ) who were negative for HBsAg but positive for anti-H C V were HCV group, and, 3)80 (21.4%) were negative for both were NBNC group. The duta were analyzed stalistically using Kaplan-Melermethod and COX proportional-hazzards regression analysis. Results:During the mean follow-up period of 3.4 years. 68(18.2 %) patients developed HCC. The cumulattive incidence of HCC. Among all patients was 25.4 % during the first 5 years: the incidences in each HBV. HCV and NBNC group during, the first 3 years were 18.3%,22.0%, and 5.6%. Respectively and those during the first 6 years were 34.7%, 54.8%, and l7.0%, respectively. By univeriate analysis age older than 50 yearser and initial serum a-PF level higher than 5ng/ml also appered to be predictors of grealer risk for the development of HCC.. By multivarite analysis. HlBsA g positivity, anti-HCV positivily, old age, and male sex were independent risk factors for HCC$quot;. Conclusion ;We showed for the first time by a prospective study that anti-HCV positive cirrhotic patients had no less or even greater risk I or the development of HCC. Than HBsAg-positive paticnl seven in in HBV-endemic korea as they had in HCV-endemic area such as Japan and Italy .

Fabrication of External Stimulus-sensitive Mechanochromic Films

최문석,장명권,김예진,류가연,황도훈,공호열,임보규 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

Currently, counterfeiting technology is becoming an issue in various fields such as food and medicine as well as luxury goods. So it is necessary to develop counterfeit prevention technologies. In recent years, colloidal crystal assemblies have been attracting many attentions as real-time external stimulus-sensitive materials in various fields. The hydrogel matrix was most commonly used to fix colloidal crystals, but it is difficult to apply to various fields due to its low mechanical strength. In this study, styrene and acrylate monomer were emulsion-polymerized to form polymer particles with a core-interlayer-shell structure, and films were prepared by rolling while applying heat to the nanospheres. When an external stimulus is applied to the film, the arrangement of nanoparticles changes in real time. Fabricated mechanochromic films are expected that it can be applied to a genuine product authentication technology that allows consumers to determine the authenticity of a product.

A STUDY ON EXPANDABILITY OF THE FLAME KERNEL AND THE COLDFLAME OF THE IGNITION SYSTEM BY THE APPLICATION OF AIS TECHNOLOGY IN LEAN-BURN CONDITION

최문석,김권세,이경태,최두석 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.1

The main objective of this thesis is to propose a method to overcome a limitation of combustion in lean-burn condition by applying the Amplified Ignition Source (AIS). In order to analyze the combustion efficiency, Constant volume combustion chamber (CVCC) was designed to conduct experiments such as flame visualization, combustion pressure and flame kernel. As the experimental and analysis conditions, Ignition device were applied to two models, C_type plug and J_type plug, and conducted the analysis and experiment with parameters of compressed pressure and air/fuel ratio. Experimental results showed that as the air/fuel ratio increased, the efficiency of C_type decreased, resulting in large combustion delay in the air/fuel ratio 1.4 area, and a misfire occurred without burning in the 1.6 area. However, in case of J_type, combustion occurred smoothly up to air/fuel ratio 1.6, and the combustion pressure was also higher than that of C_Type. In addition, In the case of coldflame expansion, J_Type was doubled at air/fuel ratio 1.0. air/fuel ratio, and the expansion of the coldflame increased as the air/fuel ratio increased. As the combustion process in the lean combustion area proceed the combustion efficiency of J-type improves.

GSK 후원 해외연수 연구보고 : 불멸화된 인간 태아간세포를 이식받은 마우스 모델에서 bioluminescent 영상의 유용성

최문석 대한간학회 2007 추계 학술대회 Vol.13 No.-

청년층의 교육 및 전공불일치가 임금과 직장만족도에 미치는 영향

최문석,송일호 동국대학교 사회과학연구원 2019 사회과학연구 Vol.26 No.2

This research investigate young employee’s education and subject mismatch has negative effects on wage and job satisfaction. First, reviewed the youth’s education and subject mismatch detailed in the recently surveyed data. 10th YP2007 data suggest that 8.2% of ‘downward employment’ , 11.3% of ‘upward employment’ and 15.0% of major mismatch exists. It shows that downward employment decreased and upward employment increased sharply when compared to existing research. So with this data compare labor market outcome(such as wage, job satisfaction) between employees. As a result, found that education mismatch’s effect on wages and job satisfaction is greater than subject mismatch. In detail, education match mainly has positive effects on ‘self development’, ‘future potential’, but subject match mainly on ‘business affair’. 본 연구는 청년취업자가 자신이 받은 교육수준 및 전공과 맞지 않는 일을 하는 경우 임금, 직장만족도와 같은 노동시장 성과를 떨어뜨리는 요인으로 작용한다는 것을 보인다. 이를 위해 우선 최근 조사된 청년패널 10차연도 자료에서 나타난 청년취업자들의 교육불일치, 전공불일치규모를 살펴보았다. 교육수준에 비해 낮은 직무를 가진 ‘하향취업’이 전체 취업자의 8.2%, 이와반대인 ‘상향취업’은 11.3%로 나타났으며, 전공불일치 취업자 비율은 15.0% 수준으로 나타났다. 이는 기존 연구에 비해 하향취업자 비중은 감소하고 상향취업은 크게 증가한 것이다. 이를 기준으로 교육‧전공불일치 취업자와 그렇지 않은 취업자들 간의 노동시장 성과(임금, 직장만족도)를 비교하되, 직장만족도를 구성하는 세부지표들의 변화에 주목하였다. 직장만족도를 구성하는 지표들 가운데, 직무와 교육일치도가 “자기발전”, “장래성”에 미치는 영향이 컸지만, 전공일치도는 “업무내용”에 대한 직장만족도를 높이는 것으로 나타나 부문별 차이가 있었다.