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김종숙(Jong Suk Kim),김호정(Ho Jung Kim),김택수(Taeg Sue Kim),박석오(Suk Oh Park),안재곤(Jae Kon Ahn),조병섭(Byung Sub Cho),어중건(Jung Gun Uh),장석일(Suk Il Chang),최대섭(Dae Sub Choi),이병철(Byung Chul Lee),강유미(Yu Mi Kang) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1
Squamous cell carcinoma of colorectum is rare disease, and squarnous cell carcinoma in situ of colorectum is very rare disease. But, squamous carcinomas of the colorectum have clinico- pathological features in common with adenocarcinomas. Treatment is the same but the prognosis of squamous cell carcinoma appears to be worse than that of adenocarcinoma. A 66-year old man has suffered chronic constipation and acute diarrhea. Barium enema and colonoscopy revealed about lobular 3cm sized mass with multiple tiny ulcerations on the surface in distal rectum. Colonoscopic biopsy and excisional biopsy showed tumor cells which are well circumscribed within columnar epithelium and basement membrane. Here, we presented a case of squamous cell carcinoma in situ of rectum. (Korean J Gastroenterol 1997; 30:114-118)
박건택(Kun Taek Park),김승욱(Seung Wook Kim),원종현(Jong Hyen Won),김재명(Jae Myoung Kim),김정한(Jung Han Kim),추길연(Gil Yen Choo),성상규(Sang Kyu Sung),장석일(Suk Il Chang),최대섭(Dae Sub Choi) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
Mucin-producing cystic tumors of the pancreas are rare. These tumors are usually confined to the body or tail of the pancreas. Definite diagnosis is established by histological findings of tumor itself. Cystadenomas and cystadenocarcinomas are treated by surgical extirpation. The prognosis of cystadenocarcinoma is relatively good. We experienced one case of cystadenocarcinoma of the head of pancreas in sixty seven year-old male patient who had been suffered from fatigue and discomfort in right upper quadrant. for a month. Abdominal ultrasound, abdominal CT and UGI series done before operation suggested cystic mass of the head of the pancreas. The patient underwent Whipple's operation. The pathologic findings were consistent with those of mucinous cystaclenocarcinoma of the head of the pancreas. The gross finding showed a well defined multilocular cyst in the uncinate process without connection to dilated main pancreas duct or distal common bile duct. The microscopic fidings showed multilocular cysts lined by atypical rnucinous epithelium intermixed with some goblet cells and surrounded by less cellular stroma. Therefore, we report the case with a review of literature.
당뇨성 위마비증상이 있는 환자에서 Erythromycin 의 위배출 시간의 단축 효과
김승욱(Seung Wook Kim),박건택(Kun Taek Park),김재명(Jae Myung Kim),원종현(Jong Hyeon Won),추길연(Gil Yeon Choo),김정한(Jung Han Kim),이범우(Bum Woo Lee),성상규(Sang Kyu Sung),최대섭(Dae Sub Choi) 대한내과학회 1993 대한내과학회지 Vol.45 No.3
N/A Backgrounds: In diabetic mellitus, many patients complain seveal symptoms cause by diabetic neuropathy. Those symptoms are including nausea, vomiting and abdominal discomfort. Erythromycin, a macrolide antibiotic, has recently been motilin like effect on gastointestinal muscles, which induces phase 3 activity that start in the stomach. Radioactive isotope is now best method for measuring gastic emptying time. Methods: First study is measuring of tincolloid labelling efficiency in gastric juice. Second study, we are evaluated the effect of erythromycin on patients with delayed gastric emptying and healthy subjects using the radionuclide technique. Twelve patients with diabetic gastoparesis and ten control subjects join in our study. Gastric emptying of solid food was determined using 99m Tc tincolloid egg. After 3 day, each patients was performed with same method after injection of intravenous erythromycin 200 mg. Results: Labelling efficiency of 99m Tc tincolloid is very satisfaction (mean±SD=87.2±4.39). Gastric emptying time is delayed in diabetic gastroparesis patients domparison with control subjects. After erythromycin injection, gastric emptying time is shortened. The time is about 1/3 than pre-eythromycin injection in patients. sixty minutes after ate meals, mean ejection fraction was 19.3% (pre-EM inject), 64.4% (post EM inject), 51.9% (control group). Conclusion: Erythromycin, mimic effect of the motilin, appears to be a very powerful gastrokinetic drug. So that erythromycin may have therapeutic effect in patient with severe diabetic gastroparesis.
간동정맥 단락을 동반한 유전성 출혈성 모세관 확장증 1례
최진욱,김호종,박성호,최대섭,김종숙,김광석,김해경,서호종,김기훈,김지겸 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.4
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterized by telangiectasias of the skin, mucous membranes, and various organ system. HHT is not unusual in western countries but there were several reported cases of HHT in Korea. Recently we evaluated a 40-year-old postpartum female who had been suffering from recurrent epistaxis and peripartum dyspnea. The patient was diagnosed as a HHT complicated by high output heart failure caused by intrahepatic arteriovenous malformation. This case is reported with a review of relevant literature.(Korea J Hepatol 2000;6:514-518).
김호정,김정한,최대섭,김택수,김재명,성상규,천대철,강유미,추길연,원종현,박석오,안장훈 대한내과학회 1994 대한내과학회지 Vol.47 No.4
Mucoepidermoid carcinoma arising in the liver is a rare malignant tumor which reported only about 10 cases to date, Several terms, such as adenosquamous carcinoma, adenoacanthoma, and mucoepidermoid carcinoma, have been used for carcinomas containing both adenomatous and squamous elements. Most of mucoepidermoid carcinoma have been reported in the salivary gland of primary site, but this tumor can also arise in many other regions of the body, such as lung, esophagus, pancreas, uterus, bladder, anus and etc. Mucoepidermoid carcinoma of the liver morphologically resembles that of the salivary gland. Histologically, this tumor consists of mixture of squamous cells, mucus-producing cells, and intermediate cells. Intercellular bridges and keratinization are also present in the epidermoid area of the tumor. We experienced a case of mueoepidermoid carcinoma arising in the liver of 68-year-old man. The tumor, measuring about 10×10 cm sized, was noted in left lobe of the liver with invasion to adjacent organs. The exploratory laparotomy was done and we obtained tissue from the tumor nodule protruding to the liver surface. Microscopically, this tumor revealed squamous element and intermingled mucoid element. And intercellular bridges and keratinization were noted in the epidermoid area. So we report this case of mucoepidermoid carcinoma of the liver with a literature review.
위선암과 우측 쇄골상 림프절의 호지킨씨 림프종이 병발한 이중 원발성 암 1 예
김호정,김규태,최대섭,김택수,천대철,문제웅,변정원,박석오,이병철,조병섭,안재곤 대한내과학회 1996 대한내과학회지 Vol.50 No.6
Double primary cancer is defined as the case of primary malignant tumors, which must be arise in different sites and have a different histologic appearances. This article is a case report of synchronous double primary cancers. We have experienced with double primary malignant tumors of different site of origin such as stomach adenocarcinoma and Hodgkin's lymphoma of right supraclavicular lymph node, which were diagnosed by biopsies with gastrofibroscopy and fine needle aspiration of right supraclavicular lymph node. For its great rarity, we report this case with review of literatures.
김보성,박윤근,김기식,서재범,최대섭,이종문 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.1
외상 후 2차적으로 발생한 측두골 골절은 많이 알려져 있으나, 중이나 내이의 손상 없이 외이도 전벽에 국한된 골절은 드물다. 외이도 전벽골절은 두부의 외상에 의한 측두골의 직접적 충격이나 하악골에 가해지는 충격에 의해 발생된다. 전형적인 증상으로는 이출혈, 전음성 난청, 개구장애가 있으며, 특히 하악골 골절 및 측두하악관절의 탈구가 동반되는 경우 개구장애, 부정교합 등의 장애를 람길 수 있으므로,, 초기에 적절한 치료를 요한다. 합병증으로는 그 외에도 외이도 협착 또는 폐쇄, 외이도 전주종, 측두하악관절의 기능장애, 윤활연골종 등이 보고되었다. 저자들은 하악골 골절 및 측두하악관절의 탈구를 동반한 외상성 외이도 전벽 골절 편위로 치험한 2예의 환자를 보고하는 바이다. Temporal bone fractures secondary to trauma have been well recognized, but localized fractures of anterior wall of the external auditory canal (EAC) without concurrent injury of middle or inner ear are rare. Direct impact to the temporal bone or mandible may result in anterior wall fracture of the EAC. The classic symptoms of the these fractures are bloody otorrhea, conductive hearing loss and trismus. Especially, EAC fractures associated with the mandibular fracture and dislocation of temporomandibular joint(TMJ) can result in various sequelaes such as trismus, malocclusion, and consequently early diagnosis and proper management is important. The reported complications of these fractures include EAC stenosis or atresia., EAC cholesteatoma, functional disability of TMJ, synovial chondromatosis. We report two patients with EAC fractures associated with the mandibular fracture and dislocation of TMJ.