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심광해,채흥복,닷, 윈디엔,이은주,배기환,강종성,김영호 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-
Gentianae scabrae Radix has been used in traditional medicine for the treatment of analgesic, anti-inflammatory and gastrointestinal tract diseases In order to evaluate the quality of Gentianae scabrae Radix, quantitative determination method of gentiopicroside has been developed by the HPLC method using the mobile phase of acetonitrile-water (1'9) and C_(18) column. The amount range of gentiopicroside in 20 samples was 0.97 to 5 89%
정명선,채흥복,최일섭,김영호,강종성,배기환 韓國藥用作物學會 2004 한국약용작물학회지 Vol.12 No.3
Gardeniae Fructus (Gardenia jasmmoides Ellis) is widely used as a natural food colorant and as a traditional medicine for the treatment of hepatic and inflammatory diseases. The quality evaluation of Gardeniae Fructus was carried out by HPLC using geniposide as a marker. The geniposide was isolated from commercial Gardeniae Fructus on ODS column using a mixed solvent of acetonitrile-water (v/v 9:91) as mobile phase and a detection wavelength 240 mm. The content of geniposides in twenty different samples was in a range of 1.20% to 7.17% of total tissues and the average was 4.97%.
당티란훵,윈디엔닷,채흥복,심광해,배기환,김영호 한국생약학회 2004 생약학회지 Vol.35 No.2
One anthraquinone and four flavonoids were isolated from the extract of leaves and twigs of Rhamnus taquetii. By physicochemical and spectral methods, their structures were identified as physcion (1), keampferol (2), rhamnocitrin (3), quercetin (4), and 3-O-methyl quercetin (5).
천연물로부터 NFAT (Nuclear factor of activated T cells) 전사인자에 대한 저해활성 탐색
이임선,닷, 윈디엔,채흥복,심광해,김영호 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-
The NFAT (nuclear factor of activatied T cells) protein induces transcription of genes required for T-cell activation, including the L - 2 gene. Activation of NFAT normally plays a significant role in inducing immune response. However, excessive activation provokes immunopathological reactions including autoimmunity, transplant rejection and inflammation. Thus, one hundred of natural products were screened on the inhibitory activity against the NFAT transcription factor. Three natural products (Celtis choseniana, Acer tegmentosum, Rubus takesimensis) showed strong inhibitory activity against the NFAT transcription factor without affecting cell viability. These MeOH extracts will be successively partitioned with CHCl₃, BuOH and H₂O to isolate active compound for the development of anti-inflammatory or immunosuppressive agent with good safety.
Cordyceps militaris 로부터 분리한 Ergosterol Peroxide 의 한국인 암세포주에 대한 항암작용
김하원(Ha Won Kim),김영호(Young Ho Kim),채흥복(Xing Fu Cai),남경숙(Kyong Suk Nam),이승정(Seung Jung Lee),안혜숙(Hye Suk An),정은호(Eun Ho Jeong),윤승현(Seung Hyun Yun),성수경(Su Kyong Sung),이성진(Sung Jin Lee),현진원(Jin Won Hyun) 한국균학회 2001 韓國菌學會誌 Vol.29 No.1
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