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기도상피세포에서 Mentha piperita 발효물에 의한 MUC5AC 억제 효능
지혜진(Hye Jin Jee),Katrina Joy Bormate,임옥(Ok Lim),정이숙(Yi-Sook Jung) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4
본 연구에서는 다양한 치료적 효능이 보고된 페퍼민트의 효능을 증진하기 위하여 유산균으로 발효하여 페퍼민트 추출발효물(FEP)을 수득하였으며, FEP의 점액 과다분비에 대한 조절 효능을 확인하고 그 기전을 규명하여 호흡기 개선에 활용될 수 있도록 정확한 용량과 효능 관계를 증명하고자 한다. 먼저 FEP는 PMA에 의해 증가한 MUC5AC의 유전자 발현 및 단백질 분비를 농도 의존적으로 억제하였으며 100 μg/mL의 농도에서 가장 효과적이었다. 이러한 억제기전은 MUC5AC 발현에 주로 관여하는 것으로 알려진 ERK/MAPK 신호전달 체계를 통해 이루어지는 것으로 추정할 수 있다. 또한 FEP의 항산화 효능을 관찰한 결과 농도 의존적인 DPPH 라디칼 소거능에 대한 효능과 ROS 억제 능력을 통해 FEP의 항산화능이 우수함을 확인하였다. 이러한 결과는 FEP가 PMA에 의해 증가한 MUC5AC의 유전자 발현을 억제하고 ERK의 활성을 억제하여 활성산소 생성조절에 관여한다. 이를 통해 FEP가 점액 과분비를 억제할 수 있는 새로운 조절제로서의 활용 가능성이 있음을 시사한다. 또한 페퍼민트의 호흡기 개선 기능을 확인하여 기능성 허브 소재로 개발한다면 현대인의 건강증진 및 기능성식품 산업발전 모두에 기여할 수 있을 것으로 사료된다. Airway mucus hypersecretion is an important clinical manifestation of asthma and can be elicited by a wide variety of endogenous and exogenous stimuli leading to airway constriction and worsening of the disease. Gene expression for MUC5AC, a principal component of mucin, is known to significantly increase in the epithelial cells of patients with asthma. Therefore, many studies have proposed that regulating the MUC5AC expression in airway epithelial cells could be a target candidate as therapy for asthma treatment. Mentha piperita, also known as peppermint, is a popular medicinal herb due to its various pharmacological uses, and polyphenolic components with strong antioxidant activity. Based on these studies, we investigated whether peppermint could improve airway function through its inhibitory effect on phorbol myristate acetate (PMA)-induced expression of MUC5AC in NCI-H292 cells, a human airway epithelial cell line. Peppermint leaves were sourced from Herb Island and fermented with Bacillus subtillis. The fermented extract of peppermint (FEP) significantly reduced PMA-induced MUC5AC mRNA expression and protein release. FEP also inhibited the phosphorylation of extracellular signal regulated kinases (ERK) and U0126 (ERK inhibitor) inhibited PMA-induced MUC5AC expression and secretion. FEP also inhibited reactive oxygen species (ROS) production, and Trolox, a ROS scavenging agent, inhibited PMA-induced MUC5AC mRNA expression and protein secretion through the inhibition of ERK activation. These results suggest that FEP can protect the respiratory tract from inflammatory damage by reducing mucus hypersecretion through the ERK signaling pathway and antioxidant activity.
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수학적 모델을 이용한 신종인플루엔자 환자 예측 및 대응 전략 평가
서민아,이지현,지혜진,김영근,강대용,허남욱,하경화,이동한,김창수,Suh, Min-A,Lee, Jee-Hyun,Chi, Hye-Jin,Kim, Young-Keun,Kang, Dae-Yong,Hur, Nam-Wook,Ha, Kyung-Hwa,Lee, Dong-Han,Kim, Chang-Soo 대한예방의학회 2010 예방의학회지 Vol.43 No.2
Objectives: The pandemic of novel influenza A (H1N1) virus has required decision-makers to act in the face of the substantial uncertainties. In this study, we evaluated the potential impact of the pandemic response strategies in the Republic of Korea using a mathematical model. Methods: We developed a deterministic model of a pandemic (H1N1) 2009 in a structured population using the demographic data from the Korean population and the epidemiological feature of the pandemic (H1N1) 2009. To estimate the parameter values for the deterministic model, we used the available data from the previous studies on pandemic influenza. The pandemic response strategies of the Republic of Korea for novel influenza A (H1N1) virus such as school closure, mass vaccination (70% of population in 30 days), and a policy for anti-viral drug (treatment or prophylaxis) were applied to the deterministic model. Results: The effect of two-week school closure on the attack rate was low regardless of the timing of the intervention. The earlier vaccination showed the effect of greater delays in reaching the peak of outbreaks. When it was no vaccination, vaccination at initiation of outbreak, vaccination 90 days after the initiation of outbreak and vaccination at the epidemic peak point, the total number of clinical cases for 400 days were 20.8 million, 4.4 million, 4.7 million and 12.6 million, respectively. The pandemic response strategies of the Republic of Korea delayed the peak of outbreaks (about 40 days) and decreased the number of cumulative clinical cases (8 million). Conclusions: Rapid vaccination was the most important factor to control the spread of pandemic influenza, and the response strategies of the Republic of Korea were shown to delay the spread of pandemic influenza in this deterministic model.
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