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주진,고현정,이규상,이재민 대한의학회 2016 Journal of Korean medical science Vol.31 No.6
Increased intraocular pressure (IOP) during surgery is a risk factor for postoperative ophthalmological complications. We assessed the efficacy of systemically infused dexmedetomidine in preventing the increase in IOP caused by a steep Trendelenburg position, and evaluated the influence of underlying hypertension on IOP during surgery. Sixty patients undergoing laparoscopic surgery in a steep Trendelenburg position were included. Patients in the dexmedetomidine group received a 1.0 μg/kg IV loading dose of dexmedetomidine before anesthesia, followed by an infusion of 0.5 μg/kg/hr throughout the operation. Patients in the saline group were infused with the same volume of normal saline. IOP and ocular perfusion pressure (OPP) were measured 16 times pre- and intraoperatively. In the saline group, IOP increased in the steep Trendelenburg position, and was 11.3 mmHg higher at the end of the time at the position compared with the baseline value (before anesthetic induction). This increase in IOP was attenuated in the dexmedetomidine group, for which IOP was only 4.2 mmHg higher (P < 0.001 vs. the saline group). The steep Trendelenburg position was associated with a decrease in OPP; the degree of decrease was comparable for both groups. In intragroup comparisons between patients with underlying hypertension and normotensive patients, the values of IOP at every time point were comparable. Dexmedetomidine infusion attenuated the increase in IOP during laparoscopic surgery in a steep Trendelenburg position, without further decreasing the OPP. Systemic hypertension did not seem to be associated with any additional increase in IOP during surgery (Registration at the Clinical Research Information Service of Korea National Institute of Health ID: KCT0001482).
주진,신지윤,윤재준,Mei Yin,윤명하 대한마취통증의학회 2018 Anesthesia and pain medicine Vol.13 No.1
Background: Curcumin is traditionally used as an herbal medicine. We explored the efficacy of intrathecal curcumin in relieving both postoperative and inflammatory pain and elucidated the mechanisms of action of curcumin interacting with g-aminobutyric acid (GABA) and opioid receptors at the spinal level. Methods: Experimental pain was induced in male Sprague-Dawley rats via paw incision or injection of intraplantar carrageenan. After examination of the effects of intrathecal curcumin on the pain, GABA and opioid receptor antagonists were intrathecally administered to explore the involvement of GABA or opioid receptors on the effect of curcumin. Additionally, the expression levels of the GABA and opioid receptors were assessed. Results: Intrathecal curcumin reduced the withdrawal threshold of both incisional surgery- and carrageenan injection-induced nociception. Intrathecal GABA and opioid receptor antagonists reversed the curcumin-mediated antinociception. Incisional surgery decreased the levels of the GABA receptors mRNA, but little changed the levels of the opioid receptors mRNA. Carrageenan injection increased the levels of the opioid receptors mRNA, but not the GABA receptors mRNA levels. Intrathecal curcumin increased or decreased the levels of GABA receptors mRNA and opioid receptors mRNA in the spinal cords of incised or carrageenan-injected rats, respectively. Conclusions: Intrathecal curcumin was effective to postoperative and inflammatory pain and such antinociception of curcumin was antagonized by both GABA and opioid receptor antagonists. Also, intrathecal curcumin altered the levels of GABA and opioid receptors. Thus, spinal GABA and opioid receptors may, respectively, be directly or indirectly involved when curcumin alleviates postoperative and inflammatory pain.
항응고제 치료를 받고 있는 환자의 수술 및 시술 시관리
주진 대한의사협회 2014 대한의사협회지 Vol.57 No.5
The periprocedural management of patients on long-term antithrombotic therapy (antiplatelet agents or vitamin Kantagonists) who may require temporary disruption, given that an invasive procedure is always a dilemma for clinicians. Discontinuation of antithrombotic therapy can place patients at an increased risk of thromboembolic complications whilethe continuation of antithrombotic therapy can increase the procedure-related bleeding risk. Therefore, it is imperativefor clinicians to be proficient in making thoughtful and individualized decisions on the appropriate management ofperiprocedural anticoagulants, drawing from recent evidence-based guidelines.
영상 콘텐츠로 바라본 사회적 이슈와 문화산업의 상관관계 연구: 할렘 르네상스의 재현 중심으로
주진,장민호 한국문화산업학회 2018 문화산업연구 Vol.18 No.4
Today's modern society is embracing the creative and imaginative power of art through technology and expanding the scope of its expression to cope with the functional role of not only art acting but also the transmission of meaning. In the case of audio-visual content distribution and the movie or music market, a combination of the above contents were often used as the subject matter or motif of events notably in the United States. Among them include Childish Gambino's music video [This is America], movie [Selma] and Kednrick Lamar’s Performance at the Grammy2015 in the modern era of American society. The narratives at the center of Social Issue are those events that happened in the past, or the similar story constructions that can be traced to the public, which can be perceived as a problem not just a past event. In addition to human rights issues and other social issues, video platform companies such as Netflix and ABC are also airing contents on TV series and making social impact input. This paper deals with the content of the public expressed in terms of the reproduction of the images of Harlem Renaissance and the implications and limitations of the social issues acting as a phenomenon in the cultural industry or as a net function of base. 현대 사회는 예술의 창의력과 상상력이 테크놀로지를 통해 수용되고 그 표현의 영역이 확장되어 예술의 외연 뿐 아니라 심연의 의미 전달에 대한 기능적 역할을 감당해 내고 있다. 영상과 음악 분야의 경우 영화나 음원시장에서 뿐 아니라 이 두 영역이 결합된 형태의 영상콘텐츠로 제작되어 입소문 마케팅으로 사용되기도 하였으며, 특히 미국에서는 사회적으로 크게 이슈가 되었던 사건들을 소재로 혹은 모티브로 사용하여 대중들을 담론의 장으로 끌어들이기도 하였다. 이 중에서도 차일디쉬 갬비노의 뮤직비디오, 영화 [겟아웃], [셀마], 켄드릭 라마의 공연은 1920년대 할렘 르네상스 시대를 살아온 미국의 흑인이 마주했던 사회의 부조리와 불평등에 대한 생각과 민족 집단으로서의 정체성, 21세기에도 현재 진행형인 인종차별의 문제와 관련된 사건들을 소재로 담아내어 당시의 문화예술이 표현하고자 하던 메시지를 함축하고 대중들이 각각의 영상이 담긴 의미를 부여할 수 있도록 하는 쌍방향 커뮤니케이션을 이끌어 냈으며, 수익을 창출하는데 일조하였다. 사회적 이슈를 중심에 둔 내러티브는 과거에 일어났던 사건 혹은 이를 추단할 수 있는 유사한 스토리 구성이 대중에게 단순히 ‘사회적 이슈’로 과거의 사건이 아닌 자신이 직면한 문제로서 인식될 수 있는 담론을 가질 수 있게 하고 대중을 응집시킬 수 있는 힘을 가지게 됨을 보여주었다. 인권 문제뿐만 아니라 다른 사회적 이슈들을 콘텐츠로 제작하는 움직임도 활발히 일어나고 있는데, 미국의 넷플릭스, ABC 와 같은 영상플랫폼 업체들도 환경, 청소년 문제에 대한 내용들을 TV시리즈로 방영하고 사회적 영향 엔터테인먼트 콘텐츠의 원활한 제작을 위한 연구를 하고 있다. 본 논문에서는 사회적 이슈가 문화산업의 하나의 현상으로 혹은 기저의 순기능으로서 역할을 하는 것에 대한 시사점과 한계점 등에 대해 할렘 르네상스의 재현이라는 관점에서 영상콘텐츠에 표현된 내용과 이에 반응하는 대중의 수용과정 및 피드백을 뇌 과학 영역에서의 거울뉴런이론 , 소비자 채택의 변화율에 대한 배스확산모델 함수, 영상의 확산에 이바지한 밈(MEME)을 통해 분석해보고자 한다.