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장기 Helicobacter pylori 감염 마우스 모델 수립과 위암 발생에 미치는 영향
김성우(Sung Woo Kim),차충근(Choong Keun Cha),한상욱(Sang Uk Han),김영배(Young Bae Kim),주희재(Hee Jae Joo),조용관(Yong Kwan Cho),조성원(Sung Won Cho),김명욱(Myung Wook Kim),함기백(Ki Baik Hahm),이원홍(Won Heung Lee) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.1
Background/Aims: This study was aimed to evaluate the long-term outcome of Helicobacter pylori (H. pylori) infection in mouse model and to know the influence of H. pylori infection on gastric carcinogenesis. Methods: Four-week-old specific pathogen free C57BL/6 mice (n=115) were infected with SS1, the mouse-adapted H. pylori strain. In the 4, 8, 16, 24, 36, 50 and 80 weeks after the bacterial inoculation, the H. pylori-infected mice were sacrificed. Results: After 80 weeks of infection, most of H. pylori-infected mice developed hyperplastic gastritis, but did not show any evidence of adenoma, dysplasia or carcinoma. Proliferating cell nuclear antigen-positive cells were most abundant at 50 weeks and tended to decrease at 80 weeks. Apoptosis was noted at 8 weeks after H. pylori infection, showing 7-8 apoptotic cells/high power field and tended to increase with the lapse of time. Normally observed neutral mucin was decreased with the lapse of time and it was remarkably decreased at 50 weeks after H. pylori infection. However, acidic mucin was remarkably noted from 50 weeks after the infection. Conclusions: SS1-infected mice seem to be suitable for H. pylori-related research and H. pylori itself does not induce gastric cancer in normal wild-type mice model in a long-term study, which could be explained by the balance between cell proliferation and apoptosis. (Korean J Gastroenterol 2002;39:22-32)
오디 괄약근 운동의 주기성에 따른 오디 괄약근 기저압의 변화
김성우 ( Sung Woo Kim ),유병무 ( Byung Moo Yoo ),김진홍 ( Jin Hong Kim ),박소윤 ( So Yoon Park ),김도현 ( Do Hyun Kim ),차충근 ( Chung Keun Cha ),함기백 ( Ki Baik Hahm ),조성원 ( Sung Won Cho ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 오디 괄약근 기능장애의 진단 기준 중 기저압이 가장 중요한 기준으로 알려져 있다. 연구자 등은 이전의 보고에서 오디 괄약근 운동이 소장의 진행성 운동 복합체(MMC)와 연관되어 주기적인 변화를 한다고 보고하였으며, 오디 괄약근의 기저압은 이러한 오디 괄약근의 주기적인 변화에 따라 변화하는 것으로 여겨진다. 그러나 단기간 내기경적 내압 검사로 괄약근의 운동의 주기적인 변화를 관찰하기는 매우 어려워, 본 연구에서는 장기간의 경피적 담도 내압 검사를
20게이지, 23게이지, 25게이지 유리체 망막 수술 기구의 비교
김대우,조성원,이태곤,김철구,김종우,이재흥,한정일,Dai Woo Kim,Sung Won Cho,Tae Gon Lee,Chul Gu Kim,Jong Woo Kim,Jae Heung Lee,Jung Il Han 대한안과학회 2013 대한안과학회지 Vol.54 No.8
Purpose: To investigate the diameter, the infusion and aspiration rate of 20-, 23- and 25-gauge vitreous cutters, and compare the theoretical and practical intraocular pressure (IOP) change according to the height of the bottle. Methods: A vitreous cutter was disassembled to measure the actual external and internal diameter. The infusion rate was measured at the height of 40, 60, 80, 100 and 120 cm and the suction rate was measured at a pressure of 100, 200, 300, 400 and 500 mm Hg for each gauge. IOP during the operation was calculated according to the bottle height and the actual IOP was measured using a mercury sphygmomanometer. Results: The external diameter of the 20-, 23- and 25-gauge was 900, 596, and 500 mm, respectively, and the internal diameter was 670, 450, and 380 mm, respectively. The infusion rate increased in direct proportion to the bottle height. The aspiration rate increased as the pressure increased. However, the increment of the infusion and aspiration rate in the 20-gauge vitreous cutter was the highest and decreased in the 23- and 25-gauge, in that order. IOP was calculated as 29, 44, 59 and 74 mm Hg when the bottle height was at 40, 60, 80 and 100 cm, respectively, and was measured 34, 50, 62 and 74 mm Hg, respectively. Conclusions: The infusion and aspiration rates per outer diameter in the 23- and 25-gauge vitreous cutters and infusions using cannula were lower than in the 20-gauge vitreous cutter. The difference of the infusion and aspiration rates per diameter between the 23- and 25-gauge vitreous cutters and infusions was not significant.
한정일,조성원,이태곤,김종우,이재흥,Jung Il Han,M,D,Sung Won Cho,M,D,Ph,D,Tae Gon Lee,M,D,Jong Woo Kim,M,D,Ph,D,Jae Heung Lee,M,D,Ph,D 대한안과학회 2008 대한안과학회지 Vol.49 No.6
Purpose: The purpose of this study is to evaluate the clinical results of 23-gauge sutureless vitrectomy. Methods: We retrospectively analyzed 111 eyes that had undergone 23-gauge sutureless vitrectomy. The eyes underwent surgery from February 2006 to July 2006 and were examined for surgical outcome as well as intraoperative and postoperative complications. Results: The preoperative best corrected visual acuity (BCVA) was 1.43±0.12 and increased to 0.88±0.11 (P>0.01). Thirteen (11.7%) of 111 eyes developed intraoperative complications, and 21 (18.9%) of 111 eyes developed postoperative complications. Intraoperative complications included wound‐leaking (seven eyes), conjunctival suture (three eyes), and difficult insertion (two eyes). Postoperative complications included postoperative hypotony (seven eyes), vitreous hemorrhage (seven eyes), hyphema (five eyes), and infectious endophthalmitis (two eyes). Conclusions: Unlike 20-gauge vitrectomy, sutureless 23-gauge vitrectomy offers all the advantages of minimally invasive sutureless vitrectomy. J Korean Ophthalmol Soc 49(6):911-916, 2008
ALT<80 IU/L인 만성 B형 간염 환자의 중등도 이상 간섬유화 유병률
이우진 ( Woo Jin Lee ),박승하 ( Seung Ha Park ),김동준 ( Dong Joon Kim ),이성화 ( Sung Hoa Lee ),이찬우 ( Chan Woo Lee ),박규태 ( Kyu Tae Park ),정재연 ( Jae Youn Cheong ),조성원 ( Sung Won Cho ),황성규 ( Seong Gyu Hwang ),이연재 대한내과학회 2010 대한내과학회지 Vol.78 No.1
Background/Aims: The aims of this study were to investigate the prevalence of significant fibrosis in patients with chronic hepatitis B (CHB) virus infections and alanine aminotransferase (ALT) <80 IU/L, and to develop a noninvasive predictive model for significant fibrosis. Methods: The 136 patients with CHB who underwent liver biopsy were recruited from six tertiary hospitals. The diagnostic value of predictors was judged using multivariate logistic modeling and the area under the receiver operating characteristic (AUROC) curve. Results: Significant fibrosis was diagnosed in 97 patients (71.3%, 95% CI, 63.7~78.9%). In the training set (n = 85), the most important clinical data for predicting significant fibrosis were age and aspartate aminotransferase (AST). The AUROC of this model was 0.86 (95% CI, 0.78~0.94). The validation set (n=51), obtained from another institute, yielded similar results [AUROC: 0.90 (95% CI, 0.78~0.99)]. Conclusions: A high prevalence of significant fibrosis in CHB patients with ALT <80 IU/L was observed. A simple model that includes age and AST provides an easily applicable tool for physicians to guide the decision-making process regarding the need to perform a liver biopsy in individual patients. However, additional studies are needed to explore the model`s performance in larger, independent patient populations. (Korean J Med 78:68-74, 2010)
이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4
본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.
삼출성 나이관련황반변성 반대안의 새로운 신생혈관 발생 빈도
이정진,유영주,조성원,김종우,Jung Jin Lee,MD,Young Ju Lew,MD,Sung Won Cho,MD,Jong Woo Kim,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.10
Purpose: To investigate the development of new choroidal neovascularization in fellow eyes of patients treated for unilateral exudative age-related macular degeneration (AMD). Methods: Three hundred fourteen patients who were first diagnosed with unilateral exudative AMD and treated with intravitreal bevacizumab or ranibizumab were studied retrospectively. Results: New exudative AMD developed in 7.0% of fellow eyes after 1 year, 10.8% after 2 years and 13.7% after more than 2 years. According to the subtype of exudative AMD, there were no significant differences between classic CNV, occult or minimally classic CNV, and PCV in the incidence of new exudative AMD. After 2 years, a higher conversion rate was found in the bevacizumab-treated group than the ranibizumab-treated group. Conclusions: The cumulative incidence of involvement in fellow eyes with exudative AMD was 13.7% over 2 years.