Sm^3+ 도핑된 GdVO4 형광체의 제조와 발광 특성

조선욱,조신호 한국진공학회 2012 Applied Science and Convergence Technology Vol.21 No.2

Gd1-xVO4:Smx^3+ phosphor powders were synthesized with changing the concentration of Sm^3+ ion by using a solid-state reaction method. The crystal structures of all the phosphors were found to be a tetragonal system, composed of (200) diffraction peak centered at 24.76°, and the morphology of grains approached the spherical form with homeogenous size distribution when the concentration of Sm^3+ ion was 0.05 mol. As for the photoluminescence properties, all of the phosphor powders, irrespective of Sm^3+ ion concentration, indicated the yellow, orange, and red emission peaked at 565, 603, and 645 nm respectively. As the concentration of Sm^3+ ion increases, the intensity of excitation spectrum showed a decreasing tendency on the increase of Sm3+ ion concentration. The maximum excitation and emission spectra were observed and the symmetry ratio was 1.19 at 0.05 mol of Sm^3+ ion. 고상 반응법을 사용하여 Sm^3+ 이온의 함량비를 변화시키면서 Gd1-xVO4:Eux^3+ 형광체 분말을 합성하였다. 모든 형광체 시료의 결정 구조는 24.76°에 중심을 갖는 (200) 주 회절 피크로 구성되는 정방정계이었으며, 결정 입자의 형상은 Sm^3+ 이온의 함량비가 0.05 mol일 때 구형에 근접하고 균일한 크기 분포를 나타내었다. 발광 특성의 경우에, Sm^3+ 이온의 함량비에 관계없이 모든 형광체 분말은 파장 565, 603, 645 nm에 피크를 갖는 각각 황색, 주황색, 적색 형광을 보였다. Sm^3+ 이온의 함량비가 증가함에 따라 흡수 스펙트럼의 세기는 감소하는 경향을 나타내었으며, Sm^3+ 이온의 함량비가 0.05 mol일 때 최대 흡수와 발광 스펙트럼이 관측되었고, 대칭비의 값은 1.19이었다.

A High Frequency of Lobectomy Instead of Total Thyroidectomy to Treat Medullary Thyroid Cancer in Korea: Data from the Korean National Health Insurance Service

조선욱 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.4

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Role of Osteal Macrophages in Bone Metabolism

조선욱 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.2

Macrophages have been shown to have pleiotropic functions in various pathophysiologies, especially in terms of anti-inflammatory and regenerative activity. Recently, the novel functions of bone marrow resident macrophages (called osteal macrophages) were intensively studied in bone development, remodeling and tissue repair processes. This review discusses the current evidence for a role of osteal macrophages in bone modeling, remodeling, and fracture healing processes.

갑상선자극호르몬이 골대사에 미치는 영향

조선욱 대한갑상선학회 2016 International Journal of Thyroidology Vol.9 No.2

Bone is a dynamic tissue undergoing life-long remodeling, a process of bone resorption by osteoclast and bone formation by osteoblast, regulated by diverse hormones including estrogen. Recently, several pituitary hormones have been identified as a modulator of this process. Here, we reviewed the role of thyroid stimulating hormone signaling per se in bone metabolism.

면역세포와 암세포의 상호작용

조선욱 대한갑상선학회 2013 International Journal of Thyroidology Vol.6 No.2

Tumor microenvironment is defined as a heterogeneous complex composed of cancer cells, vascular endothelial cells, fibroblasts, and diverse immune cells. Cancer immunology is the study of interactions between the immune system and cancer cells which is applied to develop therapeutic strategies for human cancers. This review focused on tumor promoting myeloid derived cells such as tumor associated macrophages (TAM) and myeloid derived suppressor cells (MDSC) and their therapeutic applications.

Best Achievements in Translational and Basic Thyroidology in 2020

조선욱,박영주 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.1

This review discusses articles published in 2020 that presented noteworthy achievements in translational and basic thyroidology. Previously unresolved questions about thyroid hormone receptor actions and signaling mechanisms were answered using various novel in vitro and in vivo models. Using high resolution cryo-electron microscopy, the fine functional structure of thyroglobulin was demonstrated, and new insights into the pathogenesis of thyroid disease were achieved, with a focus on research into thyroid-disrupting chemicals and the gut microbiome. Novel therapeutic approaches were tried in the field of advanced thyroid cancer treatments.

갑상선의 단일유전자질환

조선욱,박영주 대한갑상선학회 2012 International Journal of Thyroidology Vol.5 No.2

Monogenic disorder is a single gene disorder resulted of a single mutated gene. Monogenic disorder has benefits in early diagnosis and precious prediction of disease course. Furthermore, monogenic disorder could provide an informative knowledge to the understanding of related pathophysiology. Thyroid monogenic disorder could occur in various steps, such as thyroid development, hormonogenesis, TSH-receptor signaling,thyroid hormone transport and end organ response. Here, we reviewed of congenital hypothyroidism,congenital hyperthyroidism and thyroid hormone resistance syndrome.

췌장 낭성 종괴로 발현한 인슐린종 1예

조선욱,이은정,곽수헌,조영민,신찬수,박경수,김성연,조보연,이홍규 대한내분비학회 2006 Endocrinology and metabolism Vol.21 No.6

Cystic islet cell neoplasms are among the rarest entities in the differential diagnosis of cystic tumor of the pancreas, and this malady raises difficult clinical problems. The diagnosis of insulinoma could be difficult if the functional activity is incomplete, which possibly leads to blunted symptoms of hypoglycemia and failure in the laboratory to provide evidence of hyperinsulinemia. Furthermore, if the imaging shows a smaller tumor than usual or an unusual morphology like cyctic tumor, then physicians can become somewhat confused. We report here on a clinical case of cystic insulinoma with the typical neuroglycopenic symptoms and laboratory- confirmed hyperinsulinemia. At resection, a 2-cm cavitary mass without central necrosis was excised and this was confirmed histologically as a purely cystic insulioma. This is the first report of a functional cystic insulinoma of the pancreas in Korea. We suggest that the differential diagnosis of endocrine tumor must be considered for any pancreatic cyst, and especially when it is discovered in a patient who is clinically suggestive of having the associated syndrome. (J Kor Endocrinol Soc 21:552~555, 2006) 췌장의 낭성 내분비 종양은 임상적으로 매운 드문 질환으로, 모든 췌장 내분비 종양의 2~3%에 불과하다. 저자들은 췌장의 낭성 인슐린 종양으로 진단 받고 수술로써 완치된 우리나라 첫 증례를 보고하며, 췌장의 낭성 종양의 한 감별 진단으로 췌장 내분비 질환, 특히 인슐린종이 포함되어야 함을 강조하고자 한다.

Eu³⁺ 함량비가 Y_1-xPO₄:Eu_x³⁺ 적색 형광체의 발광 특성에 미치는 영향

조선욱,조신호,Cho, Seon-Woog,Cho, Shin-Ho 한국진공학회 2011 Applied Science and Convergence Technology Vol.20 No.6

고상 반응법을 사용하여 $Eu^{3+}$ 이온의 함량비를 변화시키면서 $Y_{1-x}PO_4:{Eu_x}^{3+}$ 적색 형광체를 합성하였다. 모든 적색 형광체의 결정 구조는 $25.88^{\circ}$에 중심을 갖는 (200) 주 회절 피크로 구성되는 정방정계이었으며, 결정 입자의 형상은 $Eu^{3+}$ 이온의 함량비가 증가함에 따라 구형에 근접하고 균일한 크기 분포를 나타내었다. 형광 특성의 경우에, $Eu^{3+}$ 이온의 함량비에 관계없이 모든 세라믹은 파장 593.0과 619.2 nm에 피크를 갖는 각각 적주황색과 적색 형광을 나타내었다. $Eu^{3+}$ 이온의 함량비가 증가함에 따라 여기 스펙트럼의 파장은 약간씩 장파장 쪽으로 이동하면서 흡수 세기는 증가하는 경향을 보였으며, $Eu^{3+}$ 이온의 함량비가 0.15 mol일 때 최대 흡수 및 발광 스펙트럼이 관측되었다. $Y_{1-x}PO_4:{Eu_x}^{3+}$ red phosphors were synthesized with changing the concentration of $Eu^{3+}$ ion by using a solid-state reaction method. The crystal structures of all the red phosphors were found to be a tetragonal system composed of (200) diffraction peak centered at $25.88^{\circ}$, and the morphology of grains approached the spherical form with homeogenous size distribution as the concentration of $Eu^{3+}$ ion increased. As for the photoluminescence properties, all of the ceramic phosphors, irrespective of $Eu^{3+}$ ion concentration, showed the red-orange and the red emission peaked at 593.0 and 619.2 nm respectively. As the concentration of $Eu^{3+}$ ion increased, the excitation spectrum moved into a longer wavelength with the increase of emission intensity. The maximum excitation and the emission spectrum were observed at 0.15 mol of $Eu^{3+}$ ion.

바이페닐렌과 2,3,6,7-사염화 바이페닐렌의 구조와 성질에 관한 연구

조선욱 신라대학교 자연과학연구소 1999 自然科學論文集 Vol.6 No.-

To understand the structures and properties of biphenylene and 2,3,6,7-tetrachloro biphenylene we applied the Huckel molecular orbital method for heteroatoms. The π-electron energy(??) of biphenylene is 12α + 16.5054β. This is a little bit more (0.5054β) energy than a sum of π-electronic energy of two isolated benzene molecules. The bond orders show that, in biphenylene, the structure of two 6-membered rings is very similar to an isolated benzene. And the structure of 4-membered ring is just bridging these two 6-membered rings with two single bonds. The π-electron energy of 2,3,6,7-tetrachlorobiphenylene is obtained as 20α + 32.7030β, which indicates that this molecule is very stable. From the electron charges, we found about two π electrons in the vicinity of chlorine atoms while only one π electron is found around carbon atoms. The chlorine atoms, which are located at the lateral positions in 2,3,6,7-tetrachlorobiphenylene, have high electron densities. We conclude that the high toxicity of dioxin family may be directly related with the higher electron densities of lateral chlorine atoms. The bond orders show that, among three rings of 2,3,6,7-tetrachlorobiphenylene, two outer rings show a behavior of aromaticity and these rings are connected by two single bonds. We also found that the carbon-chlorine bond is close to a single bond. This is because chlorine atoms are more electronegative than carbon atoms, the valence electrons stay close to chlorine atom as nonbonding electrons.