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산지별 고려엉겅퀴의 Pectolinarin 함량 및 항산화 활성
조봉연,이진하,라문진,김선영,강일준,한경찬,이옥환 한국식품위생안전성학회 2016 한국식품위생안전성학회지 Vol.31 No.3
This study was performed to provide basic data of Cirsium setidens Nakai by cultivars that will be applied for development of functional foods and ingredients. We assessed pectiolinarin content, total flavonoids content and antioxidant effects (DPPH radical scavenging activity and ORAC assay) of C. setidens Nakai. Our results showed that the pectolinarin and total flavonoids contents of C. setidens Nakai by cultivars ranged from 3.95±0.05 to 7.29±0.07 mg/g and from 40.42±0.91 to 76.70±2.24 mg pectolinarin equivalent (PNE)/g, respectively. Among C. setidens Nakai by cultivars, the pectolinarin content was highest in GW-D extract. Futhermore, the DPPH radical scavenging activity of C. setidens Nakai ranged from 31.25 to 81.93%, respectively. The oxygen radical absorbance capacity (ORAC) value was highest in GW-D and GW-E extracts (514.49 and 501.73 μM TE/g, respectively). These results suggest that C. setidens Nakai extract could be considered as a good sources of natural antioxidants and functional food ingredients.
조봉연,이영진 東國大學校 1999 東國論叢 Vol.38 No.-
To Improve the water quality of the piped tap water, it is necessary to use the advanced filtration treatment, which can handle the water supply deteriorated water quality. The adsorption process using the granular activated carbon (GAC) and ozone oxidation process using the bacterial activated carbon (BAC) to intestigate the treatment efficiency of advanced filtration treatment were applied for a filtration plant in Dongduchun city, Korea From this study, the treatment efficiency of ozone oxidation process was in the rage of 10%, and its efficiency of the GAC was in the range of 30-80%. The activated carbon made by coal types showed generally higher treatment efficiency than that made by coconut and wood types except for ABS and BDOC. The treatment efficiency of the GAC on the index of overall organic matter was similar to that of the BAC. However, The GAC showed higher removal efficiency for the special organic matter. Specially, the continuous ozone supply is necessary to get the appropriate treatment of the BAC and the removal efficiency improvement, because the ozone process is used as the pre-treatment for the bacterial activation.
조봉연,박미령,이진하,라문진,한경찬,강일준,이옥환 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.8
Cirsium setidens Nakai, a wild perennial herb, grows mainly in Gangwon province, Korea, and has been reported to contain bioactive ingredients with various medicinal activities, including the treatment of edema, bleeding, and hemoptysis. However, the potential antiobesity effects of C. setidens Nakai have not been fully investigated. This study evaluated the antiobesity effect of standardized C. setidens Nakai ethanolic extract (CNE) in 3T3-L1 adipocytes and in obese C57BL/6J mice fed a high-fat diet. CNE suppressed the expression of lipogenic genes and increased the expression of lipolytic genes. The antiadipogenic and antilipogenic effects of CNE appear to be mediated by the inhibition of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein (C/EBP) expressions. Moreover, CNE stimulated fatty acid oxidation in an AMPK-dependent manner. CNE-treated groups of C57BL/6J mice showed reduced body weights and adipose tissue weight and improved serum lipid profiles through the downregulation of PPARγ, C/EBPα, fatty acid binding protein 4 (FABP4), sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS) and the upregulation of adiponectin and carnitine palmitoyltransferase-1 (CPT-1) in obese C57BL/6J mice fed a high-fat diet. These results suggest that CNE may have an antiobesity effect on adipogenesis and lipid metabolism in vitro and in vivo and present the possibility of developing a treatment for obesity with nontoxic natural resources.
수확시기별 고려엉겅퀴 주정추출물의 항산화 및 항비만 활성 비교
조봉연,이진하,최선일,정태동,최승현,라문진,김선영,강일준,한경찬,이옥환 한국식품위생안전성학회 2017 한국식품위생안전성학회지 Vol.32 No.3
This study was conducted to provide basic data of Cirsium setidens Nakai in different harvest time that will be applied for development of functional foods and ingredients. We investigated pectiolinarin and pectolinarigenin content, total flavonoids content and antioxidant effects (DPPH radical scavenging activity and ORAC assay) of C. setidens Nakai. Our results showed that the pectolinarin and total flavonoids contents of C. setidens Nakai in harvesting time ranged from 43.13 ± 0.22 to 95.65 ± 0.34 mg/g and from 32.81 ± 1.68 to 40.43 ± 0.35 mg rutin equivalent (RE)/g, respectively. The DPPH radical scavenging activity of C. setidens Nakai did not show differences in harvesting time. The oxygen radical absorbance capacity (ORAC) value was highest in August (2016) extracts (827.72 μmole TE/g). In addition, C. setidens Nakai exthanolic extract in harvesting time did not show any cytotoxicity up to 200 μg/mL. During adipocyte differentiation, C. setidens Nakai extract in harvesting time significantly inhibited lipid accumulation and ROS production, compared with the controls. These results suggest that C. setidens Nakai extract could be considered as a non-toxic natural resources of functional food ingredients and natural antioxidants.
고려엉겅퀴 주정 추출물을 함유하는 임상시험제품의 항비만 활성 평가
조봉연,최선일,최승현,심완섭,Han Xionggao,라문진,김선영,강일준,한경찬,이옥환 한국식품위생안전성학회 2018 한국식품위생안전성학회지 Vol.33 No.5
본 연구는 고려엉겅퀴 주정추출물을 가지고 제작된 임 상시험용제품(CNTM)이 3T3-L1 지방세포 및 고지방식이 로 유도된 비만 쥐에 미치는 항비만 효능 관찰을 통하여 체지방 개선 기능성식품을 개발하기위하여 인체적용시험 시료를 제작한 후, 인체적용시험전에 그 효력이 유지됨을 확인하기위해 수행되었다. 본 연구에 사용된 시료 CNTM 은 80~320 μg/mL 농도에서 세포독성이 관찰되지 않았 며, 지방 축적억제 효능 및 지방세포 분화, 지질대사 관련 유전인자들을 유의적으로 변화시키는 것으로 확인되었다. 또한 동물실험에서 CNTM 처리에 의하여 체중의 감소를 확인하였으며 혈중지질 성분 가운데 HDL-C/TC의 비율은 유의적으로 증가하며 LDL-cholesterol (LDL-C)과 nonesterified fatty acid (NEFA)의 비율은 유의적으로 감소하 여 혈중 유리지방산 농도를 감소시키며 혈중 콜레스테롤 상승을 억제시키고 혈당을 감소시키는 효과가 있는 것으로 평가되었다. 따라서 고려엉겅퀴 주정추출물이 함유된 인체적용시험시료(CNTM)는 체지방 개선에 우수한 효과가 있는 것으로 확인되었다. The purpose of this study was to evaluate anti-obesity activity of Cirsium setidens Nakai test material (CNTM) in 3T3-L1 adipocytes and obese C57BL/6J mice fed with a high-fat diet using various obesity-related in vitro experiments. During adipocyte differentiation, CNTM significantly inhibited lipid accumulation and ROS production compared to controls. To evaluate whether CNTM could exert glycerol release effects on mature 3T3-L1 adipocytes, we treated cells with various concentrations of CNTM for 1 h. Treatment of mature adipocytes with 160-320 μg/mL of CNTM increased the release of glycerol, but not in a significant dose-dependent manner. Anti-adipogenic and anti-lipogenic effects of CNTM seemed to be mediated by the inhibition of PPARγ and C/EBPα. Moreover, CNTM stimulated fatty acid oxidation in an AMPK-dependent manner. CNTM-treated groups of C57BL/6J mice showed reduced body weights and adipose tissue weight with improving serum lipid profiles and adiponectin protein expression in obese C57BL/6J mice fed with a high-fat diet. These results suggest that CNTM might have anti-obesity effect on adipogenesis and lipid metabolism in vitro and in vivo. This presents the possibility of developing a treatment for obesity using nontoxic natural resources.
조봉연 대한상하수도학회 1993 상하수도학회지 Vol.7 No.2
Constant rate permeat experiments using polyethylene hollow fiber membranes were conducted in order to treat dam water for potable purposes. The experiments consisted of two series. One series consisted of six bench scale apparatuses, each having a 0.4㎡ nominal permeat area, which were applied in determining the optimum operating conditions. The other series was comprised of two pilot scale plant, each having a 40㎡ nominal permeat area. Both series were operated for six months. Coagulant was not used in any of the experiments. To suppress an increase in differential pressure between the inlet and outlet of the membrane, a hydrophilic membrane was found to be better than a hydrophobic membrane. Also, permeat flux should not be more than 0.03m/h, and air bubbling-washing for 1 minute should be conducted at 180 minutes intervals or less.