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정형오(SO Chung),홍준식(JS Hong),노경병(KB No) 대한산부인과학회 1961 Obstetrics & Gynecology Science Vol.4 No.1
1. 습관성 유조산 환자중에서 심한 경부열상이 발견되었던 환자 11예에 대하여 임상적 관찰을 하였다. 2. 경부열상에 대하여 봉합술을 시행하여야 할 시기는 유조산 직후가 비임부시보다 유리함을 알았다. 3. 경부열상은 경부측방에서 흔히 발생하였으며 좌측에서 우측보다 더 많았음을 보았다. 4. 경부열상으로 인한 습관성 유조산을 예방하기 위해 힘든 겸자분만 인공유산 둔위만출술 자연 또는 인공적 급속분만후 기타 경부열상 발생을 의심케 하는 증후가 있을 때는 항시 자궁경부 열상의 유무를 조사하여 일차봉합술을 시행할 것을 주창하는 바이다.
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정형오(SO Chung),(JC Robinson),곽현모(HM Kwak) 대한산부인과학회 1963 Obstetrics & Gynecology Science Vol.6 No.4
Introduction For many years the teaditional method of characterizing labor has been to record the length of the first, second and third stages. However, many obstetricians have felt that this was not completely accurate and was not a useful method of studying various factors such as pelvic size, analgesia, and anesthesia, so other methods have been devised. Calkins et al, used a method which studied cervical resistance. Koller and Abt. used cervical-dilatation time function to demonstrate the effect of ruptured membraned. Others have used other schemes. Friedman devised a method which would be more adaptable to statistical evaluation and the Friedman curve resulted. By carefully recording the amount of dilatation against time Friedman was able draw a curve. This curve was broken down into major areas which could then be measured. The following phases were used. The latent phase, the acceleration phase, the phase of the maximum slope, the deceleration phase and the second stage. With the exception of the phase of the maximum slope all of the phases were recorded in terms of time. The maximum slope was recorded in terms of centimeters per hour and this isa true rare. Material In this paper we have selected from the Department of Ob. & Gyn. of the Severance Hospital and the Yonsei University College of Medicine prmigravidae and multigravidae patients and have drawn labor curves for each one. There are 150 primigravida and 130 multigravida and seperate composite curves are drawn for both. In addition to these two curves a group of 80 selected noraml and ideal primigra-vida patients were selected and the curve drawn. With this basic data the variation in each phase was calculated and compared with those reported by Dr. Friedman. In almost all cases our results are similar to his and thus indicate that Korean women have much the same labor pattern that American women have. Results In the below article the various labor curves can be seen as well as the contrast with the information reported by Dr. Friedman. To further demonstrate the usefulness of this method of analysing labor special curves were drawn in which such factors as early rupture of the membranes, heavy sedation, occiput posterior, position mid-forceps delivery, uterine dysfunction and C.P.D. in general were kept constant. The data from these special curves clearly shows the influence of such factors on labor. The material collected was also analysed in another manner. This time the eases were selected by picking those cases which were found at the extremes of the various phases. For examplc those cases which had a prolonged latent phase were selected and then the various types of complicatious in this group were analysed. These sesults can be seen in the below article. Conclusions: From this study one can see that American and Korean women have much the same labor pattern. It can also be seen that this method of analysis is useful for recording the type of labor as well as the influence of various factors on labor. It is recomended that medical students and practicing obstetricians become familiae with this curve and amke use of it when following a specific patient.
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박민희,김성진,정해영,문경미,손수진,김대현,김혜림,김민조,문형룡,Pusoon Chun,제남경,Takako Yokozawa,정형오,윤휘영 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
Tyrosinase inhibitors might have potential usein cosmetic and medicinal products for the prevention ofpigmentation disorders. However, only a few inhibitors arecurrently used due to their cytotoxicity, and lack ofselectivity and stability. In this study, we synthesizedseveral tyrosinase inhibitors and investigated their activity. To investigate the action of 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908) specificallyin the inhibition of melanogenesis, a mushroomtyrosinase activity assay was performed. We confirmed theinhibitory effect of MHY908 at various melanin concentrationsusing a-MSH-induced melanoma cells. Our resultsindicate that MHY908 potently inhibited mushroomtyrosinase activity (IC50 = 8.19 lM) in a dose-dependentmanner. Through a docking simulation, we also analyzedits binding mode to inhibit tyrosinase activity. MHY908also decreased melanin synthesis without inducing cytotoxicity. These results suggest that MHY908 is a goodcandidate for prevention and treatment of pigmentationdisorders.
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