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Poly(p-dioxanone)(PPDO)의 물리적 특성과 모노필라멘트 봉합사의 In vitro 가수분해 특성
이준희,고석연,고영주,신재섭,정용석,권수한,Lee, June-Hee,Ko, Suk-Yen,Koh, Young-Joo,Shin, Jae-Sup,Chung, Yong-Seog,Kwon, Soo-Han 한국섬유공학회 2010 한국섬유공학회지 Vol.47 No.4
The bulk polymerization and thermal properties of biodegradable poly(1,4-dioxan-2-one)[poly(p-dioxanone), PPDO] were investigated. The in vitro hydrolytic degradation behavior of PPDO monofilament sutures were also examined over a 16 week period at $37^{\circ}C$ and $45^{\circ}C$. The degree of PPDO polymerization decreased with increasing content of the initiator, lauryl alcohol[$CH_3(CH_2)_{11}OH$]. The thermal stability of PPDO was inversely proportional to the content of the catalyst, Sn(II) ethylhexanoate[$Sn(Oct)_2$]. Considering the efficiency of polymerization and the thermal stability of PPDO, the proper contents of Lauryl alcohol as an initiator and ethylhexanoate as a catalyst were 1600~1900 ppm and 20~30 ppm, respectively. Based on the determination of the half crystallization time, the crystallization speeds of dyed PPDO chip and monofilament suture were higher than those of undyed PPDO chip and monofilament suture. The maximum rates of crystallization of the dyed and undyed samples were observed at around $40{\sim}50^{\circ}C$ and $50{\sim}60^{\circ}C$, respectively. At the beginning of the in vitro time, the tensile strength of the PPDO monofilament suture decreased slowly but decreased considerably after a certain period, indicating that the degradation proceeded in two steps, the first occurring in the amorphous regions and the second in the crystalline regions. The average molecular weight of the PPDO monofilament suture decreased continuously from the beginning of the in vitro time, due to the random nature of the degradation process. The breaking strength retention (BSR) and molecular weight of the PPDO monofilament suture showed a quadratic function relationship.
조병욱,방문수,정용석,조훈,류성렬 한국공업화학회 1998 응용화학 Vol.2 No.1
Shikonin, isolated from the root of Lithospermum erythrohizon, showed strong cytotoxic activity against L1210(ED_(50) = 0.06 ㎍/㎖), A549(ED_(50) = 0.78 ㎍/㎖) and T/C=112% in ICR mice bearing S-180 at a dose of 5 μmole/㎏/day. Five shikonin derivatives were synthesized and their antitumor activities were evaluated. The alkylation of 1'-OH and acylation of Ar-OH in shikonin increased that their antitumor activities in vivo, while decreased cytotoxicity in vitro compared with shikonin.
진선화, 권수한, 정용석 忠北大學校部設基礎科學硏究所 2011 自然科學硏究 Vol.25 No.-
1,5-Dihydroxynaphthalene을 출발물질로 하여 methylation, bromination, methoxylation, formylation 반응을 통하여 2-formyl-1,4,5,8-tetramethoxynaphthalene을 40%의 수율로 만들었다. 이민 화합물 6은 2-formyl-1,4,5,8-tetramethoxynaphthalene 과 2-aminoanthraquinone의 축합반응을 통하여 만들었으 며, 이 화합물을 LiAlH4로 이민 결합을 환원시킨 후 CAN으로 산화시켜 6-(((5,8-dimethoxy-1, 4-dioxo-1,4-dihydronaphthalen-2-yl)methyl)amino)anthracene-9,10-dione을 합성하였다. HCT116 세포의 apoptosis를 분석하기 위하여 고정된 핵에서 sub-G1 DNA의 양을 측정하였다. DMSO를 대조군으 로 하여 20 μM과 40μM의 농도로 실험하였을 경우 DMSO의 경우 sub-G1의 비율이 8% 정도인 것에 비하 여 compound 7의 경우는 sub-G1의 비율이 화합물의 농도가 20 μM의 경우 17%, 40 μM의 경우는 19% 로 크게 증가함을 보였다. 또한 40 μM의 화합물 (7)로 처리한 세포의 경우 형태가 변화한 것을 볼 수 있었 으며 24시간이 지난 후 관찰 되는 세포의 수가 현저하게 줄어든 것을 알 수 있었다.