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Self-assembling Helical Rod–Coil Peptoid Amphiphiles
이연재,정솔찬,안영덕,강보영,이재영,서지원 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.1
A helical rod–coil motif was employed to design water-soluble peptoid amphiphiles. Prior to this study, this approach was rarely exploited in the construction of amphiphilic peptoids. The helical rod–coil motif enabled complete dissolution of the peptoids 1 and 2 in water. The critical micelle concentration (CMC) of the water-soluble peptoids was measured. Circular dichroism (CD) analysis of each peptoid was performed to confirm the helical secondary structure in solution. Scanning electron microscopy (SEM) revealed the surface morphology of the self-assembled peptoid structures. Water-soluble peptoids comprised helical rod–coil structures provide a variety of self-assembled architectures in aqueous solutions.
Near infrared-assisted transdermal hydrogel formation
이재영,이황재,정솔찬 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
Common light sources (i.e., ultraviolet and visible light) strongly interact with biological systems and are therefore inappropriate for in vivo applications, such as transdermal polymerization. Using near infrared (NIR) light that minimally interacts with living tissues, we investigate NIR light-assisted photothermal polymerization (NAPP) of diacrylated polyethylene glycol (PEGDA), in which interactions between NIR light and gold nanorods activate a thermal initiator for polymerization of PEGDA. Gelation parameters are investigated to minimize the use of initiator and temperature increases during NAPP. Cell viability is as high as 80% after NAPP-based encapsulation. Incorporation of PEG modified with a cell-adhesive peptide moiety into the gel system further enables prolongation of cell viability during incubation up to 7 days. NAPP results in successful transdermal gelation and good viability of the transplanted cells.