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칼만 필터(Kalman Filter)를 이용한 움직이는 대상의 이동 방향 추정과 이를 활용한 무선조정자동차 제어
정성은(Sung-Eun Chung),문수진(Su-Jin Mun),조아영(A-Yeong Jo),석민아(Min-A Seok),양예슬(Ye-Seul Yang),양희은(Hee-Eun Yang),허서하(Seo-Ha Heo),김경태(Kyung-Tae Kim) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.11
2차원 상에서 움직이는 표적의 좌표와 속도를 추정하는 칼만필터의 구현을 통해 기본적인 칼만필터의 기능을 숙지한다. 구현된 칼만필터의 성능을 가시적으로 확인하고 시스템 제어에 활용해 보기 위해 아두이노로 무선조정자동차(remote control car: RC CAR)를 제작하고 표적과 동일한 궤적으로 움직이도록 제어한다.
이슈관여도가 주장의 질 인지, 정보원 공신력 인지, 그리고 태도변화에 끼치는 효과
정성은 ( Sung Eun Chung ) 한국PR학회 2012 PR연구 Vol.16 No.4
Issue involvement is one of the most studied receiver-related persuasion variables but previous findings regarding the effect of issue involvement on attitude change were mixed. The present study predicts that for freedom-restricting issues, issue involvement has a negative effect on attitude change. An experiment was conducted to test proposed hypotheses ( N = 249). The results showed that issue involvement had a negative effect on attitudes through perceived argument quality and perceived source credibility. Perceived argument quality was found to have a positive effect on perceived source credibility. Issue involvement did not moderate the effect of argument quality and source expertise on attitudes. Theoretical and practical implications of the findings were discussed.
입원 초기 지표를 통한 호스피스 환자의 퇴원 형태 예측
정성인,이승훈,김윤진,이상엽,이정규,이유현,조영혜,탁영진,황혜림,박은주,김경미,Chung, Sung-In,Lee, Seung Hun,Kim, Yun-Jin,Lee, Sang-Yeoup,Lee, Jeong-Gyu,Yi, Yu-Hyeon,Cho, Young-Hye,Tak, Young-Jin,Hwang, Hye-Rim,Park, Eun-Ju,Kim, Kyung- 한국호스피스완화의료학회 2018 한국호스피스.완화의료학회지 Vol.21 No.3
목적: 호스피스 완화의료에서 환자의 기대 여명 예측뿐 아니라 퇴원형태를 예측하여 적절한 치료를 제공할 필요가 있다. 이번 연구에서는 입원 초기 환자의 퇴원 형태 예측에 유의한 요소들을 알아보고 효율적인 완화의료의 방향에 대해 제시하고자 한다. 방법: 2016년 4월 1일부터 2017년 12월 31일까지 P병원 호스피스 병동에 입원한 말기암환자 568명 중 377명을 대상으로 하였으며 입원 시 사정한 환자의 수행 지수, 증상 및 징후, 사회 경제적 상태와 혈액검사 자료를 바탕으로 연구를 진행하였다. 결과: 입원 당시 높은 수행지수, 양호한 증상 및 징후, 정상에 가까운 혈액검사 수치를 보일 때 생존 퇴원할 가능성이 높았다. 결론: 환자의 퇴원형태 예측에 ECOG, KPS, Global health, Mental status와 같은 수행지수, dyspnea, anorexia, dysphagia, fatigue와 같은 증상 및 징후, CBC, LFT, BUN, CRP 혈액검사 수치가 유의한 지표임을 확인하였다. Purpose: To provide effective palliative care, it is important to predict not only patients' life expectancy but their discharge status at a time of inpatient admission to a hospice care facility. This study was aimed to identify meaningful life expectancy indicators that can be used to predict patients' discharge status on admission to the facility. Methods: Among 568 patients who were admitted to the hospice ward of P hospital from April 1, 2016 through December 31, 2017, 377 terminal cancer patients were selected. This retrospective cohort study was performed by using performance status, symptoms and signs, socioeconomic status, laboratory findings on admission. Results: Alive discharge was associated with a good performance status that was measured with the Karnofsky and Eastern Cooperative Oncology Group (ECOG) scales and the Global health and Mental status. Less anorexia, dyspnea, dysphagia and fatigue were also associated with symptoms and signs. Associated laboratory findings were close to normal Complete Blood Cell (CBC) count, Liver Function Test (LFT) and Blood Urea Nitrogen (BUN). Conclusion: Our findings suggest that Karnofsky Performance Status (KPS), ECOG, Global health, Mental status, anorexia, dyspnea, dysphagia, fatigue, CBC, LFT, BUN are meaningful indicators when predicting discharge status for inpatients. Further investigation is warranted.
개 자가부분 간이식에서 이식간 초기 기능 지표로서 혈청 젖산 및 아미노산의 단계별 대사 변화
김상준(Sang Joon Kim),서경석(Kyung Suk Suh),이건욱(Kuhn Uk Lee),최재운(Jae Won Choi),안세현(Sae Hyun Ahn),정성은(Sung Eun Jung),배수동(Soo Tong Pai),김주섭(Joo Seop Kim),조홍래(Hong Rae Cho),정중기(Jung Kee Chung),이우정(Woo Jung Lee 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A Living-related segmental liver transplantation is currently accepted as one method of treatments of pediatric endstage liver diseases. Immediate recovery of graft function is prerequisite for patients survival, In case of graft failure, early prediction is necessary for retransplantation to avoid decease. Since amino acids and lactic acid are metabolized in liver, levels of those components lin plasma are frequently used as indicators for hepatic graft function. we have investigated the wequential changes of amino acids and lactic acid following autologous segmental liver transplantation in canine to identify the significance of these indicators. Ten mongrel dogs were prepared by harvesting the left lobe frorn experimental dogs, removing the rest of liver using total vascular exclusion and veno-venous bypass, and implanting the left lobe taken at first stage in the orthotopic position. The plasma amino acids and lactic acid concentrations in arterial blood obtained at preoperative period, anhepatic phase, reperfusion-15 min., 1 hour, 3 hours, 6 hours, were measured on Beckman system 6300 amino acid analyzer and Kodak Ektachem 700 XR, Among ten dogs, five of them died within 20 hours (Group 1), and the rest of them died after 20 hours (Group 2). The results indicate: (1) ln both Group, all plasma amino acid levels were increased in anhepatic phase except Valine, Isoleucine, and Arginine. Most highly increased amino acid was Alanine. (2) In group 1, most amino acids were slightly decreased till reperfusion 1 hour, and then increased to the level of anhepatic phase in reperfusion 6 hours. (3) In group 2, most plasma amino acid levels were decreased to preoperative values within 6 hours following reperfusion. (4) The changing patterns of TFPAA (total free plasma amino acid), BCAA/AAA ratio (Branched chain amino acid/aromatic amino acid ratio), and severaI amino acids (Phenylalanine, alanine Proline, Tyrosine) revealed statistically significant difference between two Groupe. (5) While plasma concentration of lactate continued to rise until 6 hours after reperfusion in Group 1, already increased plasma concentration of lactate in anhepatic phase reached plateau during 6 huurs after reperfusion in Group 2. The above changing pattern of plasma concentration of lactate showed statistically significant difference between both Groups (p<0.05). (6) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased equally during operation and reperfusion in two Groups. Therefore, the sequential changes of plasma amino acids and lactic acid are useful indicators for detection of early graft function in canine autologous segmental liver transplantation
Expression of Bcl-2 Family in 4-Nitroquinoline 1-Oxide-Induced Tongue Carcinogenesis of the Rat
최재욱,정성수,이금숙,김병국,김재형,국은별,장미선,고미경,정권,최홍란,김옥준,Choi, Jae-Wook,Chung, Sung-Su,Lee, Geum-Sug,Kim, Byung-Gook,Kim, Jae-Hyeong,Kook, Eun-Byul,Jang, Mi-Sun,Ko, Mi-Kyeong,Jung, Kwon,Choi, Hong-Ran,Kim, Ok-Joon Korean Academy of Orofacial Pain and Oral Medicine 2005 Journal of Oral Medicine and Pain Vol.30 No.3
The number of patients with tongue carcinoma is increasing rapidly among young individuals in many parts of the world. Oral carcinoma progresses from hyperplastic lesion through dysplasia to invasive carcinoma and the concept of "field cancerization" with molecular alteration has been suggested for oral cavity carcinogenesis. Significant improvement in treatment and prognosis will depend on more detailed understanding of the multi-step process leading to cancer development. To induce tongue carcinoma in rat by 4-NQO, each drinking water was made to 10 ppm, 25 ppm, 50 ppm and control (only D.W. without 4-NQO). Specimens were classified into 4 groups such as control, I (mild & moderate dysplasia), II (severe dysplasia and carcinoma in situ), III (carcinoma). The mRNA expressions of Bcl-2 family were evaluated by RT-PCR technique. For anti-apoptotic Bcl-2 family, mRNA expression of Bcl-w was down-regulated in all stages of tongue carcinogenesis model. However, mRNA expression of Bcl-2 was up-regulated. For pro-apoptotic Bcl-2 family, all members were down-regulated in all stages of tongue carcinogenesis model except for Bad mRNA in group III. In terms of BH3 only protein, mRNA expressions of Bok and Mcl-1 were down regulated in all stages of specimen, but Bmf in group II and BBC3 in group III were up-regulated. Our current findings demonstrated the involvements of mRNA expression of Bcl-2 family in multi-step tongue carcinogensis. This highlights the necessity for continued efforts to discover suitable biomakers (Bcl-2 family) for early diagnosis of the disease, and to understand its pathogenesis as a first step in improving methods of treatment. The discovery of these potential biomarkers and molecular targets for cancer diagnostics and therapeutics has the potential to significantly change the clinical approach and outcome of the disease.
마우스의 급성 DSS 장염 모델에서 편도 유래 중간엽 줄기 세포의 치료 효과
송은미 ( Eun Mi Song ),정성애 ( Sung-ae Jung ),이고은 ( Ko Eun Lee ),장지영 ( Ji Young Jang ),이강훈 ( Kang Hoon Lee ),태정현 ( Chung Hyun Tae ),문창모 ( Chang Mo Moon ),주양희 ( Yang-hee Joo ),김성은 ( Seong-eun Kim ),정혜경 ( Hy 대한소화기학회 2017 대한소화기학회지 Vol.69 No.2
목적: 궤양성 대장염과 크론병으로 대표되는 염증성 장질환은 만성적인 질환으로 재발과 악화를 반복하여 환자의 삶의 질을 악화시킨다. 줄기 세포 치료는 최근 염증성 장질환을 비롯한 다양한 난치성 질환의 잠재적인 치료법으로 각광받고 있다. 새롭게 개발된 편도 유래 중간엽 줄기 세포(tonsil-derived mesenchymal stem cells, T-MSC)는 줄기 세포 고유 기능을 모두 가지며 비교적 채취가 용이하고 여러 기증자로부터 받은 세포가 잘 융화되어 자란다는 장점이 있다. 본 연구에서는 이러한 T-MSC를 dextran sulfate sodium (DSS)로 유도된 만성 장염 마우스 모델에 적용하여 그 효과를 알아보고자 하였다. 방법: C57BL/6 마우스를 각각 정상 대조군, DSS 장염군(DSS+PBS), T-MSC 투여군 (DSS+T-MSC)으로 나눠서 급성장염을 유도하였다. T-MSC 투여군에서는 급성 장염 유도 3일째에 복강 내로 T-MSC 1×106을 투여하였다. 장염의 평가는 임상 증상과 장길이, 조직학적 호전 정도로 평가하였다. 대장조직의 염증성 사이토카인을 측정하여 비교하였다. PKH26으로 표시된 T-MSC의 위치를 생체 내에서 추적하였다. 결과: T-MSC의 투여에 의하여 급성 장염 유도 마지막 날DAI가 유의하게 낮아졌으며 (11.3±1.5 vs. 8.3±1.9, p=0.015)장염 증상에 의한 체중의 감소도 완화된 소견을 보였다(-17.1±5.0% vs. -8.1±6.9%, p=0.049). 조직학적 소견을 비교하였을 때 T-MSC 투여군은 염증 세포 침투의 감소, 염증 범위의 감소 및 선와 손상의 완화 등 염증의 호전 소견이 관찰되었다 (22.6±3.8 vs. 17.0±3.4, p=0.039). 염증성 사이토카인인IL-6 and IL-1β 수치 또한 T-MSC 투여에 의하여 의미 있게 감소되었다. T-MSC의 위치를 생체 내에서 추적하였을 때 급성 장염이 유도된 대장 점막에서 T-MSC는 발견되지 않았다. 결론: 급성 장염 모델에서 T-MSC의 투여는 장염의 증상 및 조직학적인 염정 소견을 호전시켰다. 또한, 이러한 효과는 T-MSC의 생체 내 위치와는 무관한 소견으로 향후 T-MSC의 기전에 대한 추가적인 연구가 필요할 것으로 생각된다. Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitor cells currently under investigation for its efficacy as the treatment for inflammatory bowel disease. In this study, we evaluated the efficacy of tonsil-derived mesenchymal stem cells (T-MSCs) as a novel source of mesenchymal stem cells and traced their localization in a murine model of acute colitis induced by dextran sulfate sodium (DSS). Methods: C57BL/6 mice were randomly assigned to the following three groups: the normal control group, DSS colitis group (DSS+phosphate buffered saline), and T-MSC group (DSS+T-MSCs, 1x10<sup>6</sup>). The severity of colitis was assessed by determining the severity of symptoms of colitis, colon length, histopathologic grade, and levels of inflammatory cytokines. T-MSCs labeled with PKH26 were traced in vivo. Results: The T-MSC group, compared with the DSS colitis group, showed a significantly lower disease activity index (11.3±1.5 vs. 8.3±1.9, p=0.015) at sacrifice and less reduction of body weight (-17.1±5.0% vs. -8.1±6.9%, p=0.049). In the T-MSC group, the histologic colitis score was significantly decreased compared with the DSS colitis group (22.6±3.8 vs. 17.0±3.4, p=0.039). IL-6 and IL-1β, the pro-inflammatory cytokines, were also significantly reduced after a treatment with T-MSCs. In vivo tracking revealed no PKH26-labelled T-MSCs in the colonic tissue of mice with acute colitis. Conclusions: In the acute colitis model, we demonstrated that the administration of T-MSCs ameliorates inflammatory symptoms and histology. Moreover, the anti-inflammatory activities of T-MSCs were independent of gut homing. (Korean J Gastroenterol 2017;69:119-128)
만성 폐쇄형 변비의 병력이 있는 젊은 여성에서 발생한 허혈성 장염
김성은 ( Seong Eun Kim ),정성애 ( Sung Ae Jung ),심기남 ( Ki Nam Shim ),전정현 ( Chung Hyun Chun ),김희선 ( Hee Sun Kim ),신수연 ( Sue Yeun Shin ),곽재진 ( Jae Jin Kwak ),유권 ( Kwon Yoo ),문일환 ( Il Hwan Moon ) 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.1
Although ischemic colitis is often considered to be a condition occurred in elderly patients or in patients with vascular diseases, it also can occur in younger healthy persons. Some drugs, such as oral contraceptives, may play an important role in the de
뇌실복강간 단락술(Ventriculoperitoneal Shunt)을 시행한 환자에서의 서혜부 탈장의 빈도와 특성
이성철,이혁준,김기홍,정성은,박귀원,김우기,Lee, Seong-Cheol,Lee, Hyuk-Joon,Kim, Ki-Hong,Chung, Sung-Eun,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 2000 소아외과 Vol.6 No.2
Ventriculoperitoneal shunt(VP shunt) for hydrocephalus is thought to inhibit the closure of processus vaginalis and promote inguinal hernia by increasing intraabdominal pressure. To estimate the patency rate of processus vaginalis and the incidence and characteristics of the inguinal hernia, 262 cases of VP shunt in early childhood between January 1980 and May 1998 at Seoul National University Children Hospital were reviewed retrospectively. Inguinal hernia developed in 28 cases(10.7 %), but six patients had an inguinal hernia before the VP shunt was placed. Patients who had a VP shunt before 6 months of age developed inguinal hernia in 16.2 %(12/74) of cases, patients shunted between 6 months and 2 years had an incidence of 12.4 %(11/89) and only 5.1 %(5/99) of patients operated upon after 2 years of age developed hernias. Twenty-two patients out of 256 cases (8.6 %) developed inguinal hernia after VP shunt, with male predominance(M : F=4.5:1). Eight patients developed inguinal hernia bilaterally(36.4 %). It is suggested that at least 14% of processus vaginalis is patent until 2 years old.