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      • KCI등재

        한국의 요양병원에서 발생한 카바페넴장내세균 유행에 관한 고찰

        정선화,박상신 대한의료관련감염관리학회 2022 의료관련감염관리 Vol.27 No.1

        Background: Carbapenem-resistant Enterobacteriaceae (CRE) emerged in a long-term acute care hospital in 2017. Therefore, this study aimed to examine the reasons for the occurrence of the CRE epidemic, the risk of infection, its spread, and the effects of interventions. Methods: A total of 149 patients were hospitalised in a long-term acute care hospital, and 15 of 39 patients in the same ward tested positive. A retrospective cohort study was conducted on all patients (n=39) who were hospitalised in the same ward. Results: The incidence rates of CRE were 50.0% for the intensive care unit, 2.8% for each general ward, and 10.0% for the entire hospital, with a case fatality rate of 53.3%. The risk factors for its spread included antibiotic use (relative risk [RR]=18.12; 95% confidence interval [CI]=2.64-124.5), ventilator use (RR=3.95; 95% CI=1.53-10.22), decubitus (RR=15.56; 95% CI=2.27-106.8), use of tracheostomy tube (RR=2.75; 95% CI=1.06-7.12), and hemodialysis (RR=2.43; 95% CI=1.21-4.89). Conclusion: Both the incidence and case fatality rates of CRE were increased when it emerged in a long-term acute care hospital. The risk factors for its spread included antibiotic use, decubitus, tracheostomy, ventilator use, and dialysis. Interventions, including intensive infection monitoring, were effective in preventing the spread and relapse of CRE epidemics.

      • SCOPUSKCI등재
      • KCI등재후보

        여성의 하체비만관리에 대한 고주파관리와 썩션관리의 효과

        정선화 한국피부과학연구원 2008 대한피부미용학회지 Vol.6 No.3

        This study investigates into the effects of fulguration and vacuum-decompression device on lower body obesity, aiming to suggest a more professional treatment method. Its specific purpose lies in the observation of changes which occur in body components, bodily measurements, and serum fat as a result. Present study is structured based on a before & after resemblance test using different groups, asking them to fill out questionnaires. This is conducted in order to grasp their general perception on obesity. Then, among those 12 women, who are in their 20s and 30s and who have more than 52 cm in thigh circumference, 6 women underwent both fulguration and vacuum decompression treatment, while the remaining 6 underwent only the fulguration treatment. The test was conducted for 10 sessions within a 4-week period. Collected data is analyzed by conducting frequency analysis, independent-samples t-test, and paired-samples t-test from descriptive statistics, using the SPSS 12.0 Statistics program. Results of the experiment indicate that both groups decreased in their weight, BMI, and body fat, with the experiment group having more significant decrease. In terms of thigh circumference, both groups decreased significantly, with the experiment group having more significant decrease compared to the control group. In terms of serum fat, the experiment group significantly decreased in Triglyceride. Both groups showed no change in total cholesterol, HDL-cholesterol, and LDL-cholesterol. Analysis of the questionnaires shows that both groups have a poor or irregular diet and exercise routine. Although their perception of obesity is within a normal range, their self-image as being obese seems to reflect our society's tendency in overemphasizing thinness. When asked on the degree of satisfaction after using the facilities, the research subjects commented on their heating effects and that they provide better sleep. Most of the women were satisfied with the treatments and were willing to recommend this program to others. The result of this study indicates that parallel employment of the two facilities as a means to control lower body obesity is effective, especially in reducing body fat and thigh circumference, and is thus recommendable for the future application.

      • KCI등재

        톳 추출물에 의한 인체유방암세포의 세포주기 G1 Arrest 유발에 관한 연구

        정선화,최영현 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.2

        Hizikia fusiforme is a kind of brown edible seaweed that mainly grows in the northwest pacific including Korea, Japan and China, and has been widely used as a healthy food for hundreds of years. Recently, H. fusiforme has been known to exert pharmacological activities including antioxidant, antimutagenic and anticoagulant activity. However, the molecular mechanisms of H. fusiforme in malignant cells have not been clearly elucidated yet. In this study, it was investigated the effects of ethyl alcohol extract of H. fusiforme (EAHF) on the anti-proliferative effects of MDA-MB-231 and MCF-7 human breast cancer cells. EAHF treatment resulted in a concentration-dependent growth inhibition by including G1 phase arrest of the cell cycle in MDA-MB-231 and MCF-7 cells as measured by flow cytometry analysis. The G1 arrest of EAHF was accompanied by an inhibition of cyclin D1 and cyclin-dependent kinase 2 (Cdk2) expression. EAHF treatment induced the level of Cdk inhibitor p27 without significant alteration of p53 and p21 expression. However, EAHF treatment resulted in a down-regulation of retinoblastoma protein (pRB) and E2F-1 and E2F-4 expression. In addition, the cell motility of both cell lines was markedly inhibited by EAHF treatment in a time- and concentration-dependent manner. The present results suggest that EAHF has divergent biological functions and additional studies will be needed to identify the active compounds that confer the anti-cancer activity of EAHF.

      • KCI등재후보

        고주파관리와 진공감압관리가 체형관리에 미치는 효과

        정선화,최태부,이승자 한국피부과학연구원 2009 대한피부미용학회지 Vol.7 No.2

        본 연구는 고주파와 진공감압기가 체형관리에 미치는 영향을 연구하여 좀 더 전문화된 사용법을 제안하고자 시도되었으며, 그 구체적 목적은 체성분, 신체계측, 혈청지질의 변화를 관찰하였다. 연구의 설계는 비동등성 대조군 전, 후 유사실험으로 허벅지 중간 둘레가 50cm이상인 20~30대 여성 12명을 대상으로 그 중 6명은 고주파와 진공감압기를 적용하였고, 나머지 6명은 고주파만 적용하여 총 4주간 10회 실시하였다. 수집된 자료는 SPSS 12.0 통계프로그램을 이용하여 독립표본 t-검정, 대응표본 t-검정으로 분석하였다. 실험 결과 두 군 모두 체성분 분석 중 체중, BMI, 체지방은 유의하게 감소하였으나 실험군이 더 유의하게 감소되었다. 신체계측은 두 군 모두 유의하게 감소되었고, 실험군이 대조군보다 더 유의한 차이가 나타났다. 혈청지질은 실험군에서 Triglyceride가 유의하게 감소하였지만, Total cholesterol, HDL-cholesterol, LDL-cholesterol은 두 군 모두 유의한 차이가 없었다. 연구 결과 체형관리방법으로 두 가지의 기기를 병행한 관리가 특히 체성분과 허벅지 둘레의 감소에 효과적이므로 앞으로 많이 활용할 것을 제안한다. This study investigates into the effects of High Frequency Treatment and vacuum Suction device on body fatness, aiming to suggest a more professional treatment method. Its specific purpose lies in the observation of changes which occur in body components, bodily measurements, and serum fat as a result. Present study is structured based on a before & after resemblance test using different groups. Then, among those 12 women, who are in their 20s and 30s and who have more than 50 cm in thigh circumference, 6 women underwent both High Frequency Treatment and vacuum Suctionn treatment, while the remaining 6 underwent only the High Frequency treatment. The test was conducted for 10 sessions within a 4-week period. Collected data is analyzed by conducting frequency analysis, independent-samples t-test, and paired-samples t-test from descriptive statistics, using the SPSS 12.0 Statistics program. Results of the experiment indicate that both groups decreased in their weight, BMI, and body fat, with the experiment group having more significant decrease. In terms of thigh circumference, both groups decreased significantly, with the experiment group having more significant decrease compared to the control group. In terms of serum fat, the experiment group significantly decreased in Triglyceride. Both groups showed no change in total cholesterol, HDL-cholesterol, and LDL-cholesterol. The result of this study indicates that parallel employment of the two facilities as a means to control body fatness is effective, especially in reducing body fat and thigh circumference, and is thus recommendable for the future application.

      • KCI등재

        한국어 문법서 기술 방식에 관한 교사 인식 및 선호도 연구

        정선화 우리어문학회 2014 우리어문연구 Vol.49 No.-

        This article is to establish fundamental teaching materials for development of substantial and practical grammar books for Korean language through looking into teachers’ perception and preference for the methods of describing grammar books. Two groups of teachers, experienced and novice teachers, who are real consumers of grammar books for Korean language, participated in this research. Current grammar books were examined regarding how and why they were used by teachers, and teaching materials for grammar that will be published in the near future was investigated focusing on overall methods describing grammar books. In addition, concrete ways of describing grammar books were added to this study. Result of the survey showed that Korean Grammar for Foreigners 2 published by the national institute of the Korean language was a grammar book that teachers refer the most when preparing class. The survey also revealed that easy explanation for applying to class should be considered as priority. According to teaching experience, teachers had a different expectation to grammar books. Teachers who had not much experience in teaching anticipated even contents related to teaching methods, and career teachers tried to acquire a deeper knowledge of grammar from grammar books. Unlikely experienced teachers who preferred to use current grammatical terms, novice teachers preferred to change difficult grammatical terms to easy ones, which indicates appropriate grammar books need to be developed depending on experience. This study has a significant meaning of giving a suggestion on describing grammar books for Korean language that will be developed as well as reviewing current grammar books through exploring teachers’ perception and preference. 이 연구는 한국어 문법서 기술 방식에 대한 교사들의 인식 및 선호도를 조사하여 그 결과를 분석하고 보다 충실하고 실용적인 한국어 문법서 개발의 기초 자료를 마련하고자 함이다. 조사는 한국어 문법서의 실수요자들인 한국어 교사들을 대상으로 삼았으며, 초보 교사와 경력 교사로 나누어 조사하였다. 조사내용은 기존 문법서의 사용 현황과 목적, 새로 개발되는 문법서의 전반적인 내용 기술 방식 그리고 문법서의 내용을 기술하는 구체적인 방식에 관한 것이다. 조사 결과, 수업 준비 시 교사들이 가장 많이 참고하는 한국어 문법서는 국립국어원의 『외국인을 위한 한국어문법』 2였고, 문법서 기술 시 고려해야 할 사항으로 ‘수업 현장에 적용할 수 있는 쉬운 설명’에 가장 많은 응답을 하였다. 초보 교사들은 문법서에 교수법과 관련한 내용까지 기술하는 것을 기대하였고, 경력 교사들은 교수법보다는 심도있는 문법적 지식을 얻으려는 것으로 나타났다. 문법 용어의 적절성에 관한 조사에서도 기존 문법 용어의 사용을 선호한 경력교사와는 달리 초보 교사는 쉬운 용어로의 교체를 선호하여 경력에 따른 적합한 문법서 개발의 필요성을 보여주었다. 본 연구는 교사들의 인식 및 선호도 조사를 통해 기존 문법서에 대한 검토와 함께 앞으로 개발될 한국어 문법서 기술 방식에 있어서 시사점을 줄 수 있다는 의의를 갖는다.

      • KCI등재후보

        항정신약물을 복용 중인 조현병 환자에서 성기능 장애의 유병률 조사

        정선화,강시현,박동연,윤해주,박은경,이종일 대한조현병학회 2016 대한조현병학회지 Vol.19 No.2

        Objectives : Sexual dysfunction is said to affect the compliance of drug and quality of life. This study is a research to investigate the prevalence of sexual dysfunction and affecting factors that can occur when schizophrenic and schizoaffective patients have taken drugs. Methods : Subjects were 300 patients who have been taken inpatient or outpatient treatment in national seoul hospital. We used UKU-S, ASEX scale for evaluating the prevalence of sexual dysfunction and CGI-S, PANSS negative scale and CES-D for investigating the influence of psychopathology and depressive symptoms on sexual dysfunction. Results : It was reported sexual dysfunction 82.7% in male and 92.2% in female with 7 items of UKU-S. The prevalence of sexual dysfunction with criteria of ASEX was 47.72% in male and 65.05% in female. Sexual dysfunction was more prevalent in patients taking prolactin-elevation drugs. In the factor analysis for the sexual dysfunction it was investigated that age, onset time, CGI-S, PANSS negative scale, and CES-D can affect the sexual dysfunction in both male and female. Conclusion : This study reported that many patients complained of sexual dysfunction. On considering the influence of sexual dysfunction to compliance and quality of life, clinicians evaluate sexual side effects more actively because patients are more likely not spontaneously tell the sexual side effects in comparison to others.

      • KCI등재

        조선왕조실록 밀랍본 복원기술 연구(제3보) -습열열화처리를 이용한 복원용 한지의 내구성 평가-

        정선화,정선영,서진호,정소영 한국펄프·종이공학회 2013 펄프.종이기술 Vol.45 No.5

        To explore the paper materials for restoration of the Annals of the Joseon Dyansty, durability of the three type of the traditional Korean Papers were estimated in this study, through moist heat artificial aging test. Three types(D, F, and G) which showed the best preservation performance in dry heat and UV treatment in the previous study were selected and artificial accelerated aging treatment with moist-heat process was conducted; the viscosity change rate was D G F; folding endurance G D F; L* value F D G;a* and b* change rate D G F; brightness decrease rate D G F, suggesting paper F showed the least change rate in physical/optical properties. Also the CLSM image observation showed fair coherence among fibers and confirmed paper mulberry. And in FDI extraction from each sample, paper F showed the highest value. Overall, paper F (traditional glossy paper) showed the highest stability against thermal treatment. It confirms that paper F is suitable as restoration paper for tributary remains including the annals of the Joseon Dynasty for its steady strength/viscosity decrease rate and color change rate.

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