조각자가 만성 비세균성 전립선염 Rat 모델에서 혈액 및 세포조직의 변화에 미치는 영향

정기훈,장선규,최정식,조충식,김철중,Jung, Gi-Hun,Chang, Sun-Kyu,Choi, Jung-Sik,Cho, Chung-Sik,Kim, Chul-Jung 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. GLS (Gleditsiae Spina) has traditionally been used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of GLS in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Method : We observed four experimental objects of normal group, control group, testosterone group, and GLS group. Rats were treated with 17$\beta$-estradiol after castration for induction of experimental non-bacteral prostatitis, which is similar to human chronic prostatitis in histophatological profiles. GLS and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histopahological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. Also, the prostates were observed by hematological alterations of WBC, RBC, hemoglobin, hematocrit and platelet. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with GLS showed a diminished range of tissue damage. Epithelial score was improved in GLS over that of the control. The epithelial-stromal ratio was lower in GLS when compared to that of the control. Conclusion : These findings suggest that GLS may protect the glandular epithelial cells. We concluded that GLS could be a useful remedy agent for treating chronic non-bacterial prostatitis.

아차(兒茶)가 Cationic Bovine Serum Albumin 투여로 유발된 Membranous Nephropathy Mouse Model에 미치는 영향

정기훈,조충식,김철중,Jeong, Gi-Hun,Cho, Chung-Sik,Kim, Cheol-Jung 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

Objective : Membranous nephropathy(MN) is an organ-specific autoimmune disease and a relatively common cause of nephrotic syndrome in adults worldwide. But treatment of MN is not defined. This study was to evaluate the effects of Acasia Catechu extract(ACE) on the MN induced by cBSA in mice. Methods : Mice were divided into 4 groups. The normal group was injected with a saline solution. The control group was treated with cBSA(10 mg/kg i.p.) only. The third group was treated with cBSA (10 mg/kg i.p.) and ACE (250 mg/kg, p.o.). The fourth group was treated with cBSA (10mg/kg i.p.) and ACE (500mg/kg, p.o.). After cBSA and ACE treatment for 6 weeks, we measured change of body weight, 24hrs proteinuria, serum albumin, total cholesterol, triglyceride, BUN, creatinine, TNF-$\alpha$, IL-6, IL-$1{\beta}$, IFN-$\gamma$, IgA, IgM and IgG levels. The morphologic changes of renal glomeruli were also observed with a light microscope. Results : The levels of 24 hrs proteinuria, total cholesterol, triglyceride, IgG, IgM, IgA, TNF-$\alpha$, IL-6, IL-$1{\beta}$, IFN-$\gamma$ significantly decreased in both ACE groups. The level of albumin significantly increased in both ACE groups. The mRNA expression of IL-$1{\beta}$ in splenocytes considerably decreased in the ACE-500 group. In histological findings of kidney tissue, thickening of GBM decreased in both ACE groups. Conclusions : This study shows that ACE might be effective for treatment of MN. More clinical data and studies are to be done for efficient application.

하악과두에 발생된 골연골증

정기훈,김은경,Jung Gi-Hun,Kim Eun-Kyung 대한영상치의학회 1993 Imaging Science in Dentistry Vol.23 No.2

저자들은 희귀한 하악과두의 골연골종으로 진단 내려진 27세 남성 환자에서 아래와 같은 사항을 관찰하였다. 1. 임상적으로 좌측안면부의 비대칭과, 교합이상 그리고 저작 시 좌측 악관절의 동통이 있었다. 2. 방사선학적으로 좌측과두에 내측으로 균일한 방사선불투과성의 종괴가 보였으며, 좌측 하악지 길이의 증가 및 우측으로의 하악 변위가 관찰되었다. 또 골스캔상에서 좌측 악관절부위의 hot spot이 관찰되었다. 3. 조직병리학적으로 불규칙한 골의 형성과 연골모를 볼 수 있었다. Although osteochondroma is not rare in the axial skeleton and long bones, it is very rare in the jaw. It is a benign chondroma within which partial endochondral ossification occurs. There are two types, the central one and the peripheral one. Peripheral type is more common than central one in the jaw, but it is not frequent. Especially it is rare at the mandibular condyle. When it occurred at the mandibular condyle, it is generally located at the lateral portion of the condyle. In that case, facial asymmetry with occlusal change is the characteristic clinical feature. But it is similar to condylar hyperplasia so that misdiagnosis can sometimes occur. The differential point is as follows: Hyperplasia generally appears as a generalized enlargement of the condylar process with a normal cortical thickness, but osteochondroma usually appears as a focal growth or mass. We report a very rare case of peripheral osteochondroma at the mandibular condyle in a 27-year- old male patient who visited DKUDH with a chief complaint of the facial asymmetry.

귤피전원(橘皮煎元)을 처방한 만성신부전 환자 1례에 대한 보고

정기훈 ( Gi Hun Jung ),장선규 ( Sun Kyu Chang ),조충식 ( Chung Sik Cho ),김철중 ( Chul Jung Kim ) 대전대학교 한의학연구소 2007 혜화의학회지 Vol.16 No.2

어린이 통학버스 사고 예방을 위한 스마트 스쿨버스

조정민(Jung Min Cho),정기훈(Gi Hun Jeong),서방원(Bangwon Seo) 한국정보기술학회 2021 Proceedings of KIIT Conference Vol.2021 No.11

어린이 통학 버스 사고로 인하여 어린 나이에 안타깝게 목숨을 잃거나 크게 다치는 사고가 매년 발생하고 있다. 사고 요인 중 가장 빈번하게 발생하는 사고는 어린이 통학버스 갇힘 사고, 사각지대 미확인 사고 등이며, 이를 예방하기 위하여 연구를 기획하게 되었다. 적외선 송수신 센서를 통해 통학버스에 몇 명이 타고 있는지에 대한 정보를 제공하고, 초음파 센서와 적외선 거리 감지 센서를 이용하여 버스 사각지대에 대한 대책을 마련하였다. 본 연구 결과를 통하여, 어린이 통학버스 사고에 대한 위험과 발생 빈도를 줄일 수 있을 것이라고 기대된다. Accidents that lose children’s lives or seriously injur them at a young age occur every year due to children"s school bus accidents. The most frequent accidents are children"s trapping in school buses and unidentifying problem of blind spots. Therefore, this research was planned to prevent these accidents. Information on how many people are on the school bus was provided through infrared transmission/reception sensors, and counter-measures were taken against bus blind spots using ultrasonic sensors and infrared distance detection sensors. Through this research, it can be expected that the risk and accidents of children"s school bus accidents can be lowered.

CT 스캔 영상재구성과 개인용 컴퓨터를 이용한 영상 재형성과의 비교에 관한 연구

김상준,김은경,정기훈 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

Radiographic planning is needed for implant placement in order to determine implant length, jaw bone volume, anatomical stucture nd so on. Radiographic examination includes conventional radiography, conventional tomography and CT scan. The most accurate mesurement can be obtained from CT scan. For the cross-sectional view of mandible, CT scan reconstruction is generally needed. But the cross-sectional view of mandible can be reformed by personal computer. This study was performed to examine the clinical usefulness of reformed image using personal computer in comparison with CT scan reconstructed image. CT axial slices of 4 mandibles of 4 volunteers were used. Digital imaging system was composed of Macintosh Ⅱ ci computer, high resolution Sony XC-77 CCD camera, QuickCapture frame grabber board and "NIH Image" program. Seven reconstructed cross-sectional images within CT machine(CT group) were obtained. And seven reformed cross-sectional images(PC group) after digitization of CT axial slices into the personal computer were obtained. PC group was compared with CT group in the objective and subjective aspects. The results were as follow: 1.Measurement of mandibular height & width in both group showed insignificant difference(p>0.05). 2.Subjective assessment of the mandibular canal in both group showed insignificant difference(p>0.05). 3.Image reformation using personal computer could provide panoramic view, which could not be obtained in CT scan reconstruction.

치과병원에서 사용되는 진단영상에 대한 JPEG 2000 압축률에 대한 평가

정기훈,한원정,유동수,최순철,김은경 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.3

Purpose : To find out the proper compression ratios without degrading image quality and affecting lesion detectability on diagnostic images used in dentistry compressed with JPEG 2000 algorithm. Materials and Methods : Sixty Digora periapical images, sixty panoramic computed radiographic (CR) images, sixty computed tomographic (CT) images, and sixty magnetic resonance (MR) images were compressed into JPEG 2000 with ratios of 10 levels from 5 : 1 to 50 : 1. To evaluate the lesion detectability, the images were graded with 5 levels (1: definitely absent; 2: probably absent; 3: equivocal; 4: probably present; 5: definitely present), and then receiver operating characteristic analysis was performed using the original image as a gold standard. Also to evaluate subjectively the image quality, the images were graded with 5 levels (1: definitely unacceptable; 2: probably unacceptable; 3: equivocal; 4: probably acceptable; 5: definitely acceptable), and then paired t-test was performed. Results : In Digora, CR panoramic and CT images, compressed images up to ratios of 15 : 1 showed nearly the same lesion detectability as original images, and in MR images, compressed images did up to ratios of 25 : 1. In Digora and CR panoramic images, compressed images up to ratios of 5 : 1 showed little difference between the original and reconstructed images in subjective assessment of image quality. In CT images, compressed images did up to ratios of 10 : 1 and in MR images up to ratios of 15 : 1. Conclusion : We considered compression ratios up to 5 : 1 in Digora and CR panoramic images, up to 10 : 1 in CT images, up to 15 : 1 in MR images as clinically applicable compression ratios.

하악과두에 발생된 골연골종

정기훈,김은경 大韓口腔顎顔面 放射線學會 1993 Imaging Science in Dentistry Vol.23 No.2

Although osteochondroma is not rare in the axial skeleton and long bones, it is very rare in the jaw. It is a benign chondroma within which partial endochondral ossification occurs. There are two types, the central one and the peripheral one. Peripheral type is more common than central one in the jaw, but it is not frequent. Especially it is rare at the mandibular condyle. When it occurred at the mandibular condyle, it is generally located at lateral portion of the condyle. In that case, facial asymmetry with occlusal change is the characteristic clinical feature. But it is similar to condylar hyperplasia so that misdiagnosis can sometimes occur. The differential point is as follows: Hyperplasia generally appears as a generalized enlargement of the condylar process with a normal cortical thickness, but osteochondroma usually appears as focal growth or mass. We report a very rare case of peripheral osteochondroma at the mandibular condyle in a 27-year-old male patient who visited DKUDH with a chief complaint of the facial asymmetry.