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척수손상 쥐에서 인간 배아 줄기세포의 이식이 기능적 회복에 미치는 효과
정광익,박창일,박은숙,신지철 대한재활의학회 2008 Annals of Rehabilitation Medicine Vol.32 No.5
Objective: To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord. Method: Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5×103/5μl, 2×104/5μl). The hES cells were transplanted 1 week after a SCI. Results: The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter. Conclusion: These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI.
뇌졸중 환자에서 Cutaneous Silent Period와 경직의 상관관계
정광익,최형종,고원진,전아영,유우경,이정기 대한근전도전기진단의학회 2008 대한근전도 전기진단의학회지 Vol.10 No.1
Objectives: The cutaneous silent period (CSP) is a spinal inhibitory reflex related to the stimulation of slow-conducting A-δ fibers. The aim of this study is to evaluate the relationship between spasticity and CSP in patients with stroke. Methods: Twelve stroke patients with hemiplegia were enrolled in the study. The CSP was recorded from the thenar muscles during voluntary contraction. A stimulation train consisting of five noxious electrical shocks was applied to ipsilateral digit II cutaneous nerve to record the CSP. Modified Ashworth scale (MAS) was assessed by an experienced physician. Results: The means of CSP durations were 83.08±18.26 ms and 56.50±9.74 ms on the affected side and the sound side respectively. The CSP duration on the affected side was significantly longer than that of the sound side (p<0.05). The difference of CSP duration between sound side and affected side did not correlate well with the MAS. Conclusion: Our findings showed that the CSP duration on the affected side was longer than that of the sound side and did not correlate well with the MAS. The CSP may be one of the useful tools to evaluate central nervous system. Further study will be needed to find out correlation between the CSP and the spasticity.
장소연,정광익,유우경,정명훈,온석훈 대한재활의학회 2016 Annals of Rehabilitation Medicine Vol.40 No.6
Objective To assess the risk factors for delirium in patients admitted to a rehabilitation unit for acute or subacute neurological or musculoskeletal disorders.Methods We reviewed the medical records of 537 patients admitted to a rehabilitation unit and selected 398 patients in the acute or subacute stage of various neurological or musculoskeletal disorders. Among them, patients who had suffered from delirium were categorized into the delirium group (n=65), and the other patients were categorized into the non-delirium group (n=333). As potential risk factors for delirium, the patients’ diagnosis, underlying disease, demographic data, hospital stay duration, surgery, and laboratory findings were reviewed, and the differences between the two groups with respect to independent risk factors were analyzed.Results The average age in the delirium group was higher; the hospital stay and pre-transfer periods were longer. A large proportion of the patients were admitted for musculoskeletal disorders, and many patients had diabetes mellitus, dementia, and depression as underlying diseases. Laboratory tests revealed increases in the white blood cells (WBC), glucose, blood urea nitrogen (BUN), total bilirubin, aspartate transaminase (AST), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels in the delirium group, while the hemoglobin, calcium, phosphorus, protein, albumin, and potassium levels were decreased. Depression, musculoskeletal disorders, traumatic brain injury, elevated WBC, BUN, AST, and CRP levels, and decreased potassium and phosphorus levels were identified as independent risk factors for delirium. Conclusion Risk factors treatable before delirium onset were identified in rehabilitation patients in acute and subacute stages of various disorders. Early diagnosis and prevention of these risk factors could decrease delirium occurrence and increase rehabilitation effectiveness.