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L-Tryptophan투여에 의한 간내 Triglyceride 축적에 대한 실험적 연구
金濟炫,全裕相,宋正錫 최신의학사 1971 最新醫學 Vol.14 No.1
L-Tryptophan is one of the essential amino acids and a component of body protein. The metabolites of tryptophan, niacin, serotonin and tryptamine demonstrated many biochemical, physiologic and pharmaco?logic roles. Also tryptophan is involved in body metabolism through enzyme induction, gluconeogenesis and enzyme agreggation. In 1966 Kim observed additional effect of tryptophan, namely the accu?mulation of triglyceride following the injection of tryptophan. "Fatty liver" as defined by the hepatocellular infiltration with fat and the accumulation of triglyceride has been investigated by many workers. Carbon tetrachloride, ethionine, phosphorus, azaserine, ethahol and a choline deficient diet can produce a fatty liver. The investigation has confirmed the finding of triglyceride accumulation following the injection of tryp?tophan, and the mechanism of this effect has been studied. Male albino rats weighing 200-250g, prior to the experiment, have been fed a diet 15% casein for one week. L-Tryptophan 0.34 mMole per rat have been injected intraperitoneally into the intact or adrenalectomized rats. Three hours later the rats have been sacrificed, and the concentration of hepatic triglyceride, free fatty acid and citrate have been determined. To study the mechanism of the accumulation of the triglyceride in vivo and in vitro experiments using Warburg' s apparatus have been carried out. Results are as follows: 1. A single injection of 0. 34 mMole of tryptophan produced hepatic triglyceride accumulation which appeared by 2. 5 hours after the injection and disappeared after 24 hours. 2. Multiple injections(5 days) of tryptophan increased hepatic triglyceride but only to the same extent as seen following a single injection. This indicates the phenomenon was only temporal. 3. Only tryptophan among the general amino acids caused an increase in hepatic triglyceride. 4. Results of studies on the mechanism of tryptophan-triglyceride effect; a) An accumulation of triglyceride was demonstrated in adrenalectomized rats. b) Following the administration of reserpine the rats were given L-tryptophan, and a subsequent increase was noted in the hepatic triglyceride. c) Although L-methionine usually has a lipotropic effect it failled to stop accumulation of trigly?ceride following tryptophan injection. d) In Warburg' s system(in vitro study) using acetate-1-14C tryptophan stimulated lipid biosynthesis in the liver slice. f) In vivo and in vitro tryptophan increased the amount of citrate in the liver and plasma. Citrate could accelerate the rate of lipid synthesis. f) There was no difference between the tryptophan treated and the control in the rate of palmitate -1-14C oxidation.
진동긴박이 비타민 결핍 백서의 전위부 궤양발생에 미치는 영향
김현옥,전유상,김이식,송정석 ( Hyun Ock Kim,Yoo Sang Chun,Ei Sik Kim,Chung Suk Song ) 생화학분자생물학회 1969 BMB Reports Vol.2 No.2
Since the production of hyperplastic ulcers of forestomachs of rats fed on low protein diet by Fibiger in 1913, many investigators produced the same lesions on the rats. In this laboratory, the hyperplastic ulcers of forestomachs of rats fed on low protein diet was produced in a shorter period by shaking the rats. In this experiment, production of ulcers of forestomachs of the riboflavin or thiamine deficient rats by giving shaking stress was investigated. The results were follows; No ulceration of forstomachs of the riboflavin or thiamine deficient rats fed on 20% casein diet was produced by shaking the rats. However, severe hyperplastic ulcers of forestomachs of the thiamine deficient rats fed on 91% rice diet were produced by shaking the rats, while no change of those of rats fed 91% rice diet were observed by the same treatment. So it is concluded that the thiamine deficiency accelerates the production of hyperplastic ulcers of the forestomachs of rats fed on low protein diet.
진동긴박(振動緊迫)이 비타민결핍(缺乏) 자서(自鼠)의 전위부(前胃部) 궤양발생(潰瘍發生)에 미치는 영향(影響)
김현옥,전유상,김이식,송정석,Kim, Hyun-Ock,Chun, Yoo-Sang,Kim, Ei-Sik,Song, Chung-Suk 생화학분자생물학회 1969 한국생화학회지 Vol.2 No.2
Fibiger 가 1913 년(年)에 저단백식이(低蛋白食餌)로 기른 백서(白鼠)의 전위부(前胃部)에 비후성(肥厚性) 궤양(潰瘍) 발생(發生)을 관찰(觀察)한 이래(以來) 많은 학자(學者)들에 의하여 같은 궤양(潰瘍)을 발생(發生)시키었다. 본교실(本敎室)에서는 저단백식이(低蛋白食餌)로 기른 백서(白鼠)에게 진동긴박(振動緊迫)을 가(加)하면 단시일(短時日)안에 전위부(前胃部)에 비후성궤양(肥厚性潰瘍)이 발생(發生)되는 것을 관찰(觀察)하였다. 본실험(本實驗)은 riboflavin 혹은 thiamine 결핍(缺乏) 백서(白鼠)에게 진동긴박(振動緊迫)을 가(加)하고 그 전위부(前胃部) 궤양(潰瘍) 발생(發生) 여하(如何)를 관찰(觀察)한 것이다. Since the production of hyperplastic ulcers of forestomachs of rats fed on low protein diet by Fibiger in 1913, many investigators produced the same lesions on the rats. In this laboratory, the hyperplastic ulcers of forestomachs of rats fed on low protein diet was produced in a shorter period by shaking the rats. In this experiment, production of ulcers of forestomachs of the riboflavin or thiamine deficient rats by giving shaking stress was investigated. The results were follows; No ulceration of forstomachs of the riboflavin or thiamine deficient rats fed on 20% casein diet was produced by shaking the rats. However, severe hyperplastic ulcers of forestomachs of the thiamine deficient rats fed on 91% rice diet were produced by shaking the rats, while no change of those of rats fed 91 % rice diet were observed by the same treatment. So it is concluded that the thiamine deficiency accelerates the production of hyperplastic ulcers of the forestomachs of rats fed on low protein diet.
陳東植,尹亨善,全裕相 中央醫學社 1970 中央醫學 Vol.19 No.2
The clinical analysis of 395 cases of paralytic poliomyelitis observed during five years period from Jan. 1965 to Dec. 1969, has been reported and compared with the previous studies done by Dr. Lim and Ko(1211 cases, 1954~1961) and Dr. Hur et al(322 cases, 1962~1964) at the Dept. of Pediatrics, Yonsei Univ. College of Medicine. 98.7% of the 395 cases were found to occur under the age of five years, 92. 5% under 3 years, with the highest peak by age occurring between 12 and 24 months(45. 1%). This picture of age distribution is similar to that found in the previous studies and is supposed to be one of the characteristics of the disease in Korea. Taking the seasonal incidence into account it was found that 56.5% of the cases occurred in the summer from May to Sept. However more sporadic cases were found to occur throughout the year than had previously been reported. The trend that the disease is more frequent in males than in females is consistent with the previous reports. Looking at the vaccination status, it was found that 68.6% of the reported cases had not received vaccination, was the 20% remaining having received vaccinations irregularly and incompletely. This fact present a very important problem in the aspects of child health in Korea, even though it indicates an improvement the vaccination status as compared with previous reports(78.2% had not received vaccinations in the previous reports.). On the past histories, they had following diseases within the last 3 months before the onset, malnutrition, 34. 7%, Measles, 9.6%, chronic diarrhea, 6.1%, frequent URI, 7.1% and Chicken pox, 1.0%. Subsequently 58.3% of the cases were reported as abnormal growth and health. The clinical picture of the initial symptoms which includes fever, 70.9%, cough, coryza, diarrhea and vomiting, is similar to that of previous reports.