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이상준,박진용,임태형,윤영호,권순대,남창욱,허규찬,박근용,구본식,김상표,장종억 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3
저자들은 인슐린 비의존형 당뇨병 환자에서 통증성 구강내 미란 및 전신성 수포성 미란을 동반한 심상성 천포창 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Various skin conditions such as diabetic dermopathy, necrobiosis lipoidica diabeticorum, bullosis diabeticorum, granuloma annulare occur frequently in diabetes, although common lesions may be associated by chance. Pemphigus vulgaris(PV) is a blistering skin disease seen predominantly in elderly patients. This disorder is characterized by the loss of cohesion between epidermal cells with the resultant formation of intraepidermal blisters. These blisters rupture easily, leaving denuded areases that may crust and enlarge peripherally. In half or more of patients, lesions begin in the mouth: approximately 90% of patients have oromucosal involvement at some time during the course of their disease. But the relationship of this disorder with diabetes is not clear. We experienced a case of pemphigus vulgaris associated with NIDDM in 67 years old woman who was admitted due to painful oral ulcer and control of blood glucose, so we present this case with a review of literatures.
위 출구 폐색을 초래하여 내시경적 절제술로 치료한 Brunner 선 과오종
김기홍,이옥재,심대석,정기문,장종억 대한내과학회 1998 대한내과학회지 Vol.54 No.1
Brunner's gland hamartomas are rare, benign duodenal tumors. But, they are the commonest hamartomas in the small intestine and believed to represent hyperplasia of Brunner's glands, perhaps in response to excessive gastric acid secretion. Brunner's gland hamartomas are usually smaller than 1cm and asymptomatic, incidental finding during endoscopy or radiographic examination. We report a case of large Brunner's gland hamartoma which prolapsed into gastric antrum and caused gastric outlet obstruction, and was resected by endoscopic polypectomy.
당뇨병성 신증환자에서 혈청 크레아티난치와 적혈구의 Malondialdehyde(MDA) 및 항산화효소의 상관 관계에 관한 연구
박성배,김현철,박근용,강미정,곽춘식,문교철,장종억,신원승 대한신장학회 1997 Kidney Research and Clinical Practice Vol.16 No.3
Oxygen free radical activity is elevated in diabetes mellitus and has been implicated in the etiology of vascular complications and diabetic nephropathy is a serious microvascular complication in patients with IDDM. Despite intensive investigation, the pathophysiology of diabetic renal disease has not been fully elucidated. However, several clinical and experimental studies have suggested that endothelial dysfunction and changes of peritubular microcir culation might deteriorate renal function in patients with IDDM. We performed this study to examine the oxidative sss and correlation between levels of serum creatinine and erythrocytic MDA, SOD, catalase, GPX in IDDM patients with diabetic nephropathy. Twenty one patients with IDDM(diabetic duration $gt;5 years) and persistent albuminuria(albumin excretion$gt;1000mg/day) and 15 normal healthy controls were investigated prospectively for erythrocytic MDA(thiobarbituric acid assay) and antioxidant enzymes[SOD(Hyland et al.), catalase(Nelson and Kiesow), GPX(Palgia and Valentine)] and correlation to serum creatinine levels. Levels of erythrocytic MDA were significantly higher in patients with diabetic nephropathy than in normal healthy controls(p$lt;0.05) and levels of erythrocytic antioxidant enzymes were significantly lower in patients with diabetic nephropathy than in normal healthy controls(p$lt;0.05). There was no significant correlation between serum levels of creatinine and erythrocytic MDA in group 1(r=0.12, p$gt;0.05) and group 2(r=0.12,p$gt;0.05) but there was significant correlation between serum levels of creatine and erythrocytic MDA in group 3(r=0.96, p$lt;0.05). There was no significant correlation between serum levels of creatinine and erythrocytic antioxidant enzymes in all patients with diabetic nephropathy groups(group 1, group 2, and group 3; p$gt;0.05). We concluded that increased oxidative stress and decreased antioxidative defense mechanism might be factors in the initiation of diabetic nephropathy and the oxidative stress correlated with higher serum levels of creatinine(more than 5mg/dL)(p$lt;0.05).
이태원,김우식,김경환,홍성표,양문호,김명재,임천규,장종억,한승묵 대한신장학회 1996 Kidney Research and Clinical Practice Vol.15 No.4
Renal oncocytoma, a benign tumor composed of eosinophilic cells which show abundant mitochondria on electron microscopy,($quot;oncocytes$quot;) is a well-documented entity. Before the 1976 review by Klein and Valensi, few cases of renal oncocytoma were reported in the world biomedical literature, witb Zippel recognizing the first case in 1942. Increased awareness and improved diagnostic modalities have led to well over 600 cases of renal oncocytoma currently described in other country. In Korea renal oncocytoma has been reported since 1986. We report herein a case of renal oncocytoma that was found incidentally by aMominal ultrasonogram and treated by the radical nephrectomy.