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선천성 고혈압 성장 백서에서의 카테콜아민 합성효소에 관한 연구
서유헌,전양숙,최웅,김헌식,임정규,김성수,박찬웅,조현섭 대한내분비학회 1989 Endocrinology and metabolism Vol.4 No.3
Central catecholaminergic nerves have an integral place in the central connections of the autonomic nervous system. It has long been thought that sympathetic nervous system plays an importantpart in the regulation of blood pressure, but there is no firm evidence of excessive activity of the sympathetic nervous system in development and maintenance of essential hypertension. It seems clear that central catecholaminergic systems participate in the regulation of normal blood pressure. However, it is not yet clear which system is altered in hypertension and which changes are of primary causal importance and which are secondary in nature. In the present study, we investigated activities of catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine β-hydroxylase (DBH), phenylethanolamine N-methyl transferase (PNMT) in various regions of the brain and the adrenals in spontaneous hypertensive (SH) and normotensive wistar rats at 16 weeks of age when the hypertension is fixed. TH, DBH and PNMT activities n the adrenal glands of SH rats were significantly higher than that those of normotensive wistar rats. TH activity was higher in the hypothalamus of SH rats than that of wistar control rats. In the medulla, DBH activity of SH rats was lower than that of wistar rats. But PNMT activity was higher in the medulla of SH rats than that of wistar rats. These results suggest the possibility of over-activity of the adrenal medulla of SH rats and a participation of both norepinephrine and epinephrine neurons in the maintenance of hypertension. (J. Kor Soc Endocrinol 4:231~239, 1989)
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조정래,Sanghoon Shin,Jung-Sun Kim,고영국,홍명기,Yangsoo Jang,승기배,박헌식,Seung-Jea Tahk,임도선,Dong-Wun Jeon,In Ho Chae,김덕경,Junghan Yoon,정명호,최동훈 대한심장학회 2012 Korean Circulation Journal Vol.42 No.8
Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-cen-ter registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M : F=297 : 231. The prevalent risk factors for AAS in-cluded hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%),IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0%underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further,prospective study is warranted with a larger number of patients.
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