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김가을,임충만,김현철,정윤기 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
At the interface of an implanted neural probe, immune responses inevitably limit the recording performance of the device. To prevent these negative actions, we designed and fabricated titanium substrates covered with cell membranes which were extracted from differentiated PC12 cells to induce the surface localization of neural cell adhesion molecules, which promotes neurite outgrowth and neural network formation. The surface modification was investigated with FT-IR, confocal laser scanning microscopy observation and fluorescence recovery after photo-bleaching (FRAP) assay. Further, in vitro cell study revealed encouraging results in terms of adhesion and differentiation of neuronal cells, showing different behaviors of astrocytes from those of neuronal cells. In conclusion, our study demonstrates that this approach may act as an efficient tool for modulating immune responses derived from neural probe.
강종희,임충만,이미현,정윤기 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Graft-through technology is emerging in the development of blood-contacting medical devices such as intravenous catheter. To improve their resistance to infection and thrombosis, the technology was studied and applied to develop a catheter prototype, peripherally inserted central venous catheter (PICC). Grafting condition of zwitte-rionic monomers, such as SBMA, CBMA, MPC, on the catheter surface that previously compounded with biofunctional oligomeric additives was investigated. Optimized conditions are applied to the prototype of PICC and evaluated in aspects with therapeutic efficacy and biological safety. The prototype underwent water contact angle measurement, lubricant test, plasma protein adsorption test, thrombus accumulation with blood loop apparatus, bacterial adhesion assay, cytotoxicity test and in vivo intravenous insertion in Canine model. These results will be employed to commercialize the PICC and utilized to expand to various blood-contacting medical devices.
이미현,임충만,최수연,강종희,정윤기 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
To improve sufficient antifouling properties, zwitterionic materials have been proposed as new generation materials to inhibit protein adsorption and formation of biofilm. Moreover, it has been demonstrated that fluorinated materials have antifouling and antimicrobial effects. In this study, novel zwitterionic and tetra-fluorinated polyurethane (ZFPU) additives were blended with polyvinyl chloride (PVC) to evaluate anti-fouling and anti-thrombotic effects. 1HNMR and FT-IR analyses showed that the zwitterionic groups and fluorinated groups were successfully introduced onto the ZFPU backbone. We also investigated the protein adsorption, platelet adhesion and wettability of additives-blended PVC films. Our results demonstrated that the ZFPU additives-blended PVC surfaces significantly suppressed protein adsorption and platelet adhesion compared to those of pristine PVC surface.
최수연,양승원,임충만,강종희,정윤기 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
To prevent the anti-thrombosis and the bacterial biofilm formation, zwitterionic or fluorinated macromolecules have been proposed as a surface-modifying oligomer (SMO) for the surface modification of polymeric biomaterials. In this study, novel oligomers with zwitterionic and tetra-fluorinated polyurethane backbones (ZFPU) were synthesized and blended with polyvinyl chloride (PVC) to evaluate anti-fouling and anti-thrombotic effects. 1H NMR and FT-IR have demonstrated that zwitterionic groups and tetra-fluorinated segments were successfully introduced to the ZFPU backbone. We also investigated the protein adsorption, platelet adhesion and the wettability of ZFPU/PVC films. These results demonstrated that the surface of ZFPUs-blended PVC significantly suppresses the protein adsorption and the platelet adhesion/ activation compared to those of the pristine PVC. It is expected that our novel SMOs will have high hope for blood-contacting medical devices.
강종희,최수연,임충만,정윤기 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Although polyurethane (PU) based materials have been commonly used for biomedical devices due to their biocompatibility and mechanical properties, thrombosis and infection occurrence is still major problems. To prevent these, zwitterion groups have emerged as new generation of anti-fouling materials to inhibit protein adsorption and adhesion of platelet. In addition, some metal ions are known to their anti-microbial properties. Herein, we designed a series of metal ion-complexed zwitterionic polyurethane (m-zPU) additives to confer non-fouling and -microbial properties to polyvinyl chloride (PVC). Consequently, it is demonstrated that m-zPU additives significantly lowered protein adsorption and enlarged the zone of bacterial inhibition than pure PVC.
강종희,최수연,임충만,정윤기 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
To improve sufficient antifouling properties, zwitterionic materials have been proposed as new generation materials to inhibit protein adsorption and formation of biofilm. Moreover, many studies have demonstrated that fluorinated materials have antifouling and antimicrobial effects. Here, we designed novel zwitterionic and tetrafluorinated polyurethane (ZFPU) additives to confer anti-fouling and anti-thrombotiic effects and blended these with polyvinyl chloride (PVC). 1HNMR and FTIR analyses showed that the zwitterionic groups and fluorinated groups were successfully introduced onto the ZFPU backbone. We also investigated the protein adsorption, platelet adhesion and wettability of additives-blended PVC films. Our results demonstrated that the ZFPU additives-blended PVC surfaces significantly suppressed protein adsorption and platelet adhesion than those of pristine PVC surface.
최수연,강종희,임충만,고원건,정윤기 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
We designed novel zwitterionic and tetra-fluorinated polyurethane (ZFPU) additives to confer anti-fouling and anti-thrombotic effects and blended these with polyvinyl chloride (PVC). 1HNMR and FTIR analyses showed that the zwitterionic groups and fluorinated groups were successfully introduced onto the ZFPU backbone. We also investigated the protein adsorption, platelet adhesion and wettability of additivesblended PVC films. Our results demonstrated that the ZFPU additivesblended PVC surfaces significantly suppressed protein adsorption and platelet adhesion than those of pristine PVC surface. Based on these results, it is expected that our novel additives will be promising for various biomaterials, including blood-contacting medical devices.