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고원건 나노기술연구협의회 2023 Nano Convergence Vol.10 No.21
In this study, we present a promising and facile approach toward the fabrication of non‑toxic, water‑stable, and eco friendly luminescent fiber paper composed of polycaprolactone (PCL) polymer and CsPbBr3@SiO2 core–shell per ovskite nanocrystals. PCL‑perovskite fiber paper was fabricated using a conventional electrospinning process. Trans mission electron microscopy (TEM) clearly revealed incorporation of CsPbBr3@SiO2 nanocrystals in the fibers, while scanning electron microscopy (SEM) demonstrated that incorporation of CsPbBr3@SiO2 nanocrystals did not affect the surface and diameter of the PCL‑perovskite fibers. In addition, thermogravimetric analysis (TGA) and contact angle measurements have demonstrated that the PCL‑perovskite fibers exhibit excellent thermal and water stability. The fabricated PCL‑perovskite fiber paper exhibited a bright green emission centered at 520 nm upon excitation by ultra violet (UV) light (374 nm). We have demonstrated that fluorescent PCL‑perovskite fiber paper is a promising candidate for anti‑counterfeiting applications because various patterns can be printed on the paper, which only become visible after exposure to UV light at 365 nm. Cell proliferation tests revealed that the PCL‑perovskite fibers are cytocompat ibility. Consequently, they may be suitable for biocompatible anti‑counterfeiting. The present study reveals that PCL perovskite fibers may pave way toward next generation biomedical probe and anti‑counterfeiting applications.
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Application of Cellular Micropatterns to Miniaturized Cell-based Biosensor
고원건,이현종,Sang Won Han,Ui Seok Chung 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.3
Because of strong demands for high throughput or high content cell-based assay, significant efforts have focused on the assay miniaturization by fabricating cell microarray using a variety of cell patterning techniques such as spotting, photolithography or soft lithography and by integrating cell microarray into microfluidic devices. Response of cells cultured on microarray can be monitored by using either electrochemical or optical detection methods. Impedancebased detection and potential-based detection have been widely used for electrochemical detection, while optical detection relies mostly on the fluorescence and bioluminescence-based techniques. Resultant cell microarray-based biosensor can be applied for high throughput/content drug screening and detection of pathogens, pollutants and warfare agents. For the successful application of cell-based biosensors to various areas, multi-phenotypic cell microarray should be developed and cells on microarray must be cultured in 3-dimensional environment as they do in real tissue to obtain accurate response of cells against target analytes.
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