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생체 흡수성 코폴리머 고정판을 이용한 안와골절 정복술의 장기적인 임상 결과
임재석,박도훈,곽주영 대한안과학회 2009 대한안과학회지 Vol.50 No.7
Purpose: This study examined the postoperative long-term results of the reconstruction of orbital wall fracture using MacroporeⓇ. Methods: The long-term results for 10 patients who were diagnosed with orbital wall fracture and received the repair of orbital wall fracture using MacroporeⓇ, were examined postoperatively after an average of 23.5 months. Results: The mean difference in orbital volume between the fractured orbit and the unaffected orbit after an average of 23.5 months postoperatively was 1.01±0.70 cm³ (4.75±2.92%), which slightly increased compared to 0.70±0.52 cm3 (3.26±2.10%) immediately after the operation, although the difference was not statistically significant (p-value=0.190). At the last follow-up, the shape of MacroporeⓇ was not observed in 3 out of the 10 patients, and intense ossification was observed at the site of fracture in 6 patients. At the last follow-up, one patient showed 1.5 mm enophthalmos, and the other patients did not show the occurrence of diplopia or the progress of enophthalmos. Conclusions: According to the long-term results of the reconstruction of orbital wall fracture, MacroporeⓇ is considered an implant that produces a safe and satisfactory effect without notable complications. 목적: MacroporeⓇ를 이용한 안와골절 정복술의 장기적인 임상 결과에 대해 알아보고자 한다. 대상과 방법: 안와골절로 진단 받고 MacroporeⓇ를 이용하여 안와골절 정복술을 시행한 10명의 환자들을 대상으로 수술 후 평균 23.5 개월이 경과한 후의 장기적인 임상 결과에 대해 알아보았다. 결과: 수술 후 평균 23.5개월이 경과한 후의 골절측과 비골절측의 안와용적의 차이는 평균 1.01±0.70 cm3 (4.75±2.92%)로 수술 직후 0.70±0.52 cm³ (3.26±2.10%)와 비교하여 약간의 증가를 보였지만 통계적으로 유의하지 않은 수준이었다(p-value=0.190). 마지막 경과 관찰에서 10명의 환자 중 3명에서 MacroporeⓇ의 음영을 확인할 수 없었으며 6명의 환자에서 골절 부위의 분명한 골화를 확인할 수 있었다. 1명의 환자에서 1.5 mm의 안구함몰을 보였고 그 외 환자들의 경우 복시의 발생이나 안구함몰의 진행은 보이지 않았다. 결론: MacroporeⓇ는 안와골절 정복술의 장기적인 임상 결과에 있어 뚜렷한 합병증 없이 안전하고 만족할 만한 효과를 얻을 수 있는 삽입물이라 생각된다.
HA/TCP 골이식재상에 이식된 지방유래 줄기세포의 골모세포로의 분화 및 골형성에 대한 연구
임재석,권종진,장현석,이의석,정유민,이태형,박정균,Rim, Jae-Suk,Gwon, Jong-Jin,Jang, Hyon-Seok,Lee, Eui-Seok,Jeong, You-Min,Lee, Tai-Hyung,Park, Jeong-Kyun 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.2
Aim of the study: An alternative source of adult stem cells that could be obtained in large quantities, under local anesthesia, with minimal discomfort would be advantageous. Adipose tissue could be processed to obtain a fibroblast-like population of cells or adipose tissue-derived stromal cells (ATSCs). This study was performed to confirm the availability of ATSCs in bone tissue engineering. Materials amp; Methods: In this study, adipose tissue-derived mesenchymal stem cell was extracted from the liposuctioned abdominal fat of 24-old human and cultivated, and the stem cell surface markers of CD 105 and SCF-R were confirmed by immunofluorescent staining. The proliferation of bone marrow mesenchymal stem cell and ATSCs were compared, and evaluated the osteogenic differentiation of ATSCs in a specific osteogenic induction medium. Osteogenic differentiation was assessed by von Kossa and alkaline phosphatase staining. Expression of osteocyte specific BMP-2, ALP, Cbfa-1, Osteopontin and osteocalcin were confirmed by RT-PCR. With differentiation of ATSCs, calcium concentration was assayed, and osteocalcin was evaluated by ELISA (Enzyme-linked immunosorbant assay). The bone formation by 5-week implantation of HA/TCP block loaded with bone marrow mesenchymal stem cells and ATSCs in the subcutaneous pocket of nude mouse was evaluated by histologic analysis. Results: ATSCs incubated in the osteogenic medium were stained positively for von Kossa and alkaline phosphatase staining. Expression of osteocyte specific genes was also detected. ATSCs could be easily identified through fluorescence microscopy, and bone formation in vivo was confirmed by using ATSC-loaded HA/TCP scaffold. Conclusions: The present results show that ATSCs have an ability to differentiate into osteoblasts and formed bone in vitro and in vivo. So ATSCs may be an ideal source for further experiments on stem cell biology and bone tissue engineering.
Molecular genetic decoding of malformations of cortical development
임재석,이정호 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.1
Malformations of cortical development (MCD) cover a broad spectrum of developmental disorders which cause the various clinical manifestations including epilepsy, developmental delay, and intellectual disability. MCD have been clinically classiἀed based on the disruption of developmental processes such as proliferation, migration, and organization. Molecular genetic studies of MCD have improved our understanding of these disorders at a molecular level beyond the clinical classiἀcation. These recent advances are resulted from the development of massive parallel sequencing technology, also known as next-generation sequencing (NGS), which has allowed researchers to uncover novel molecular genetic pathways associated with inherited or de novo mutations. Although an increasing number of disease-related genes or genetic variations have been identiἀed, genotype-phenotype correlation is hampered when the biological or pathological functions of identiἀed genetic variations are not fully understood. To elucidate the causality of genetic variations, in vivo disease models that reḀect these variations are required. In the current review, we review the use of NGS technology to identify genes involved in MCD, and discuss how the functions of these identiἀed genes can be validated through in vivo disease modeling. Molecular genetic decoding of malformations of cortical development