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임용근,김현지,박경순 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
Manganese dioxide nanoparticles (MnO2 NPs) have been typically synthesized using polymers asreducing agents to reduce permanganate and/or as coating agents to increase colloidal stability. However,thus far, there have been no reports regarding methods for preparing MnO2 NPs using permanganate andonly metal ion chelator. Herein, we proposed a new method for synthesizing MnO2 NPs by directlyreducing permanganate using diethylenetriamine pentaacetic acid (DTPA) as a metal ion chelator. MnO2NPs were synthesized by the simple reaction of DTPA as a chelating and reducing agent with differentmolar ratios of potassium permanganate (KMnO4). The synthetic DTPA/MnO2 produced nano-sizedparticles with sizes ranging from 208 nm to 241 nm, with negatively charged surfaces. The DTPA/MnO2NPs that were synthesized at a molar ratio of 1:4 (DTPA:KMnO4) exhibited the highest stability andstorage stability in deionized water. Further, the DTPA/MnO2 NPs could be rapidly degraded in thepresence of hydrogen peroxide and simultaneously generate oxygen. Thus, in this study, we report thesuccessful synthesis of novel MnO2 NPs using the metal ion chelator DTPA. Moreover, we believe that thisNP-synthesis method will be widely applied to synthesize new types of MnO2 NPs using various metalchelators.
임용근,김현지,박경순 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
We proposed a new method for synthesizing MnO<sub>2</sub> NPs by directly reducing permanganate using diethylenetriamine pentaacetic acid (DTPA) as a metal ion chelator. MnO<sub>2</sub> NPs were synthesized by the simple reaction of DTPA as a chelating and reducing agent with different molar ratios of potassium permanganate (KMnO<sub>4</sub>). The synthetic DTPA/MnO<sub>2</sub> produced nano-sized particles with sizes ranging from 208 nm to 241 nm, with negatively charged surfaces. The DTPA/MnO<sub>2</sub> NPs that were synthesized at a molar ratio of 1:4 (DTPA:KMnO<sub>4</sub>) exhibited the highest stability and storage stability in deionized water. Further, the DTPA/MnO<sub>2</sub> NPs could be rapidly degraded in the presence of hydrogen peroxide and simultaneously generate oxygen. Thus, in this study, we report the successful synthesis of novel MnO<sub>2</sub> NPs synthesized using the metal ion chelator DTPA. Moreover, we believe that this NP-synthesis method will be widely applied to synthesize new types of MnO<sub>2</sub> NPs using various metal chelators.
김현지,임용근,송영준,박경순 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
Hypoxia in the tumor microenvironment (TME) is a major barrier to photodynamic cancer therapy (PCT)that entails oxygen-dependent cell killing. TME-responsive manganese dioxide (MnO2) nanoparticleshave been used to alleviate hypoxia as well as improve the efficacy of PCT. However, many types ofMnO2 nanoparticles do not have sufficient colloidal dispersity and stability as well as tumor targetingability. To solve these problems, we developed a novel well-dispersible, tumor targetable-, TMEresponsive-,and hypoxia alleviating-MnO2 nano-photosensitizer through the reaction of folatepolyethyleneglycol-tetraethylenepentamine-chlorin e6 (Ce6) (FAPTEC) with Mn2+ under alkaline pHconditions to produce FAPTEC/MnO2 nanoparticles. The prepared FAPTEC/MnO2 nanoparticles exhibitedgood colloidal dispersity and stability under biological conditions, and they significantly increased oxygenproduction in situ following their degradation in the hypoxic TME, leading to enhancing singlet oxygengeneration after laser irradiation. Moreover, after folate receptor-mediated cellular uptake,cytocompatible FAPTEC/MnO2 nanoparticles effectively alleviated hypoxia inside 4T1 cells with highhydrogen peroxide production under hypoxic conditions. Importantly, they also exerted more potentphototherapeutic effects under normoxic and even hypoxic conditions after laser irradiation comparedto other photosensitizers (free Ce6 and FAPTEC). Therefore, our results suggest that FAPTEC/MnO2nanoparticles provide promising nano-photosensitization for enhancing hypoxia alleviation-triggeredphototherapeutic effects on hypoxic tumor cells.
Facile Fabrication of Oxygen-Releasing Tannylated Calcium Peroxide Nanoparticles
박지선,송영준,임용근,박경순 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
This study reports a new approach for the facile fabrication of calcium peroxide (CaO<sub>2</sub>) nanoparticles using tannic acid (TA) as the coordinate bridge between calcium ions. Tannylated-CaO<sub>2</sub> (TA/CaO<sub>2</sub>) nanoparticles were prepared by reacting calcium chloride (CaCl<sub>2</sub>) with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in ethanol, containing ammonia and different amounts of TA (10, 25, and 50 mg). The prepared TA/CaO<sub>2</sub> aggregates consisted of nanoparticles 25-31 nm in size. The nanoparticles prepared using 10 mg of TA in the precursor solution exhibited the highest efficiency for oxygen generation. Moreover, the oxygen generation from TA (10 mg)/ CaO<sub>2</sub> nanoparticles was higher in an acidic environment.