http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정지창,임성빈,박승준,정주호,고계창,장성구,노영수,Jung, Jee-Chang,Yim, Sung-Vin,Park, Seung-Joon,Chung, Joo-Ho,Ko, Kye-Chang,Chang, Sung-Goo,Rho, Young-Soo The Korean Society of Pharmacology 1996 대한약리학잡지 Vol.32 No.1
일부 malignant tumor에 Pt-complex의 임상 응용 과정에서 신장독성등의 심한 부작용이 문제점으로 지적되고 있다. 이 연구에서는 기존의 cisplatin보다 항암효과는 우수하면서, 부작용을 감소시킨 새로운 Pt complex의 개발에 역점을 두었다. 본 연구에서 합성한 Pt(II) complex는 carrier ligand로서 1,2-diaminocyclohexane(dach)을 사용하였고, leaving group으로는 diphosphine류인 1,3-bis (diphenylphosphine의 propane(DPPP) 을 도입하였으며, 물에 대한 용해도를 높이기 위해 dinitrate로 만들었다. 새로이 합성한 [Pt(II)(cia-dach)(DPPP)].$(NO_3)_2$ <PC-1>은 원소 분석, IR 및 $^{13}C-NMR$ 분석 data에 의하여 위의 물질임이 확인되었다. PC-1은 MTT assay method에 의한 항암활성 연구를 통하여 SKOV-3, OVCAR-3 human ovarian adenocarcinoma cells에서 항암효과가 인정되었으며, 이 항암효과는 대조 약물로 사용된 cisplatin과 유사하였다. PC-1은 토끼의 신세뇨관 세포와 인체의 신피질 세포를 이용한 cytotoxity 및 thymidine 섭취율과 인체 신피질 조직 배양을 이용한 glucose consumption 실험을 통하여 모두 cisplatin보다 신장독성이 현저히 감소되었다. 이상의 결과로 보아 Pt(II) complex는 carrier ligand와 leaving group의 선택에 따라 항암활성의 증가와 신독성의 감소를 일으키는 요인으로 보여지며, 이 연구에서 만들어진 새로운 Pt(II) complex는 앞으로 다각적인 검토를 거쳐 새로운 anticancer chemotherapeutic agent로 개발될 가능성이 있을 것으로 생각된다. Platinum coordination complexes are currently one of the most compounds used in the treatment of solid tumors. However, its use is limited by severe side effects such as nephrotoxicity. Our platinum-based drug discovery program is aimed at developing drugs capable of diminishing toxicity and broadening the clinical spectrum of activity of cisplatin. We synthesized new Pt(II) complex analogue containing 1,2-diaminocyclohexane (dach) as carrier ligand and 1,3-bis(diphenyl phosphino)propane (DPPP) as a leaving group. Furthermore, nitrate was added to improve the solubility. A new series of PC-1 [Pt(cis-dach) (DPPP)]. $2NO_3_2$ was synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (IR), $^{13}carbon$ nuclear magnetic resonance (NMR)]. PC-1 was demonstrated acceptable antitumor activity aganist SKOV -3, OVCAR-3 human ovarian adenocarcinomacells and significant activity as compared with that of cisplatin. The toxicity of PC-1 was found quite less than that of cisplatin using MTT, $[^3H]thymidine$ uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. Based on these results, this novel platinum compound represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low toxicity.
원보 : 파스틱 정(R)(나테글리니드 90mg)에 대한 글루나테 정(R)의 생물학적 동등성
탁성권 ( Sung Kwon Tak ),이진성 ( Jin Sung Lee ),최상준 ( Sang Joon Choi ),서지형 ( Ji Hyung Seo ),이명재 ( Myung Jae Lee ),강종민 ( Jong Min Kang ),류주희 ( Ju Hee Ryu ),홍승재 ( Seung Jae Hong ),임성빈 ( Sung Vin Yim ),이경태 ( 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.2
단보 : 인체 혈장중 라베프라졸의 정량을 위한 LC-MS/MS 분석법 검증 및 단일 용량 투여에 의한 약물동태 연구
탁성권 ( Sung Kwon Tak ),서지형 ( Ji Hyung Seo ),류주희 ( Ju Hee Ryu ),최상준 ( Sang Joon Choi ),이명재 ( Myung Jae Lee ),강종민 ( Jong Min Kang ),이진성 ( Jin Sung Lee ),홍승재 ( Seung Jae Hong ),임성빈 ( Sung Vin Yim ),이경태 ( 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.1
한국인 무릎 골 관절염 환자들의 임상 양상과 Apo-1/Fas (CD95) 유전자 다형성과의 상관관계에 관한 연구
홍승재,양형인,임성빈,정주호,정영옥,김호연,Hong, Seung-Jae,Yang, Hyung-In,Yim, Sung-Vin,Chung, Joo-Ho,Jung, Young-Ok,Kim, Ho-Youn 대한면역학회 2003 Immune Network Vol.3 No.2
Background: Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary knee osteoarthritis, MvaI restriction length polymorphism (RFLP) in human Apo-1/Fas (CD95) gene was assessed. Methods: Genotype and allele frequencies in promoter region in the Apo-1/Fas (CD95) gene were studied by PCR-RFLP in 226 Korean controls and 148 Korean patients with primary knee osteoarthritis. Results: No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the knee oateoarthritis patients. But in the severe grade (grade 3, 4) Kellgren-Lawrence score patients, the frequency of $MvaI^*1$ (G) allele was significantly decreased (P=0.0392) and the of $MvaI^*2$ (A) allele frequency was significantly increased (P=0.0473) compared to the normal controls. Conclusion: Apo-1/Fas (CD95) gene polymorphism is a part a determinant factor of severity in knee osteoarthritis, the patients with $MvaI^*2$ (A) allele is more severe radiologic progression. Further substantiation studies are needed in larger patient samples and various other apoptosis related genes to elucidate the mechanism of osteoarthritis, including the Fas ligand gene analysis.
정주호,김양제,임성빈,박승준,고계창,정지창,Chung, Joo-Ho,Kim, Yang-Che,Yim, Sung-Vin,Park, Seung-Joon,Ko, Kye-Chang,Jung, Jee-Chang The Korean Society of Pharmacology 1994 대한약리학잡지 Vol.30 No.1
포만중추 (satiety center)를 자극하여 음식섭취를 억제한다고 알려진 CCK-8을 흰쥐 복강에 투여하여, 흰쥐 뇌의 도파민 변화에 대한 CCK-8의 효과를 관찰하였다. 흰쥐 뇌의 부위별 도파민 함량은 HPLC-ECD방법으로 측정하였으며, 시상하부와 흑질에서의 TH-immunoreactive neuron은 면역조직화학법과 영상분석법을 시행하였다. 굶긴 쥐에서는 정상 쥐에 비하여, 도파민 함량이 전두 피질, 해마, 시상하부 및 편도체에서 각각 감소하였다. CCK-8을 투여한 쥐는 정상 쥐와 굶긴 쥐에 비하여, 도파민 함량이 시상하부에서 의미있게 감소하였다. 또한 굶긴 쥐는 정상 쥐와 비교하여, TH-positive neuron의 분포와 수가 뇌실옆핵, 깔때기핵, 정중융기 및 혹질에서 현저히 감소하였다. CCK-8투여시, 시상하부와 흑질에서의 TH-immunoreactive neuron의 수는 굶긴 쥐에 비하여 증가하였다. 이상의 실험 결과로 보아 음식물 섭취를 억제하는 작용이 있는 CCK-8은 시상하부의 도파민 신경계와 일부분 관련되어 있으며, 또한 시상하부와 흑질에 존재하는 TH-positive neuron은 음식물 섭취 행위에 중요한 역할이 있음을 시사하고 있다. The present study was aimed at establishing what changes occur in the dopamine levels and pattern of TH-immunoreactive neurons of certain areas of rat brain during food intake suppression produced by intraperitoneally administration of CCK-8. CCK-8 in dose of $10\;{\mu}g/kg$ was injected intraperitoneally to 48 h food-deprived rats. In the fasted group, the contents of dopamine were decreased in the frontal, striatum, hypothalamus and amygdala as compared to those of the fed control group. The administration of CCK-8 showed significant decrease on the dopamine levels of the hypothalamus, in comparison to those of the sated and starved group. During deprived condition, the density and number of TH-immunoreactive neurons in the paraventricular nucleus, arcuate nucleus, median eminence and substantia nigra were lower than those of the fed control group. After administration of CCK-8, the pattern and distribution of TH-positive neouons in the hypothalamic areas and substantia nigra were increased when compared to those of the starved group. It is concluded that the results demonstrate the partial involvement of hypothalamic dopamine-containing neurons in the feeding inhibition of CCK-8. Furthermore, the results indicate that TH-immunoreactive neurons play on important role in the hypothalamus and substantia nigra for eating behavior
액토스<sup>TM</sup>정(염산 피오글리타존 15 mg)에 대한 피로스<sup>TM</sup>정의 생물학적 동등성
강종민,이명재,서지형,최상준,이진성,류주희,탁성권,임성빈,홍승재,이경태,Kang, Jong-Min,Lee, Myung-Jae,Seo, Ji-Hyung,Choi, Sang-Jun,Lee, Jin-Sung,Ryu, Ju-Hee,Tak, Sung-Kwon,Yim, Sung-Vin,Hong, Seung-Jae,Lee, Kyung-Tae 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.2
The purpose of the present study was to evaluate the bioequivalence of two pioglitazone HCl tablets, $Actos^{TM}$, tablets (Lilly Korea. Ltd., Korea) as a reference drug and $Piros^{TM}$, tablets (Reyon Pharm. Co., Ltd., Korea) as test drug, according to the guideline of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received one tablet containing pioglitazone HCl 15 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of pioglitazone were monitored for over a period of 36 hr after administration by using a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The area under the plasma concentration-time curve from time zero to 36 hr ($AUC_{0-36hr}$), maximum plasma drug concentration ($C_{max}$) and time to reach $C_{max}$ ($T_{max}$) were complied from the plasma concentration-time data. Analysis of variance (ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_{0-36hr}$ and $C_{max}$. The 90% confidence intervals of the $AUC_{0-36hr}$ ratio and the $C_{max}$ ratio for $Piros^{TM}$/$Actos^{TM}$. were log 0.8753-log 1.1286 and log 0.8669-log 1.1734, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25, recommended by KFDA. In all of these results, we concluded that the $Piros^{TM}$. tablet was bioequivalent to the $Actos^{TM}$. tablet, based on the rate and extent of absorption.
단보 : 건일로딘 캡슐(에토돌락 200 mg)에 대한 에토딘 캡슐의 생물학적동등성
이명재 ( Myung Jae Lee ),강종민 ( Jong Min Kang ),최상준 ( Sang Jun Choi ),이진성 ( Jin Sung Lee ),탁성권 ( Sung Kwon Tak ),서지형 ( Ji Hyung Seo ),류재환 ( Jae Hwan Rew ),임성빈 ( Sung Vin Yim ),이경태 ( Kyung Tae Lee ) 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.6
한국인 퇴행성 관절염 환자에서 Glutathione-S-Transferase 유전자의 다형성 연구
최대정(Dae Jung Choi),김용호(Yong Ho Kim),김범식(Bum Shik Kim),임성빈(Sung-Vin Yim) 대한스트레스학회 2008 스트레스硏究 Vol.16 No.2
퇴행성 관절염의 발생에 유전적인 원인이 관련되어 있다는 증거가 최근 밝혀지고 있다. Glutathione-S-transferase (GST) 유전자는 몸안의 발암물질, 화학독성물질, 기타 다른 여러 유독 물질의 해독에 매우 중요한 역할을 하는 것으로 알려지고 있으며 산화적 스트레스에도 관여하는 것으로 알려지고 있다. 한국인 퇴행성 관절염 환자에서 퇴행성 관절염의 발생과 GST 유전자 다형성의 연관관계를 알아보기 위하여 111명의 한국인 퇴행성 관절염 환자와 537명의 한국인 대조군에서 연구를 수행하였다. 모든 연구는 헬싱키 선언의 지침에 따라 수행되었고 모든 환자 및 대조군에서 동의서를 받았다. GSTM1과 GSTT1 유전자의 다형성이 분석되었다. GSTM1 유전자 다형성은 퇴행성 관절염 환자와 대조군에서 통계적으로 유의한 차이를 나타내었다[χ<SUP>2</SUP>=7.9605, p=0.0045, odds ratios (95% confidence intervals)=1.8154(1.1954∼2.7570)]. GSTT1 유전자 다형성 역시 두 군 간에 의미 있는 차이를 나타내었다[χ<SUP>2</SUP>=10.1853, p=0.0014, odd sratios (95% confidence intervals)=1.9816 (1.2957∼3.0306)]. GSTM1 유전자와 GSTT1 유전자를 동시에 분석한 결과 두 개의 유전자가 모두 결핍된 군 두 개의 유전자를 모두 갖고 있는 군이 통계적으로 의미있는 차이를 나타내는 것을 알 수 있었다[χ<SUP>2</SUP>=7.6575, p=0.0057, odds ratios (95% confidence intervals)=2.1685 (1.1796∼3.9865)]. 이상의 결과는 GST유전자 다형성이 한국인 퇴행성 관절염 환자에서 퇴행성 관절염의 발생과 연관되어 있음을 나타낸다. Recent reports have been suggested the association between osteoarthritis and genetic polymorphism. Glutathione-S-transferase (GST) plays an important role in the detoxification of carcinogen, chemical toxins, and other harmful materials in the body. To investigate the possible association between osteoarthritis and GST gene polymorphism, 111 Korean osteoarthritis patients and 537 Korean healthy control subjects were evaluated. All studies were carried out according to the Declaration of Helsinki guidelines and written informed consent was obtained from each subject. The polymorphisms of GSTM1 and GSTT1 genes were analyzed. The distribution of GSTM1 polymorphism between osteoarthritis patients and controls was significantly different [χ<SUP>2</SUP> = 7.9605, p=0.0045, odds ratios (95% confidence intervals)=1.8154 (1.1954∼2.7570)]. The distribution of GSTT1 polymorphism was also significantly different between two groups [χ<SUP>2</SUP>=10.1853, p=0.0014, odds ratios (95% confidence intervals)=1.9816 (1.2957∼3.0306)]. In the combined analysis of GSTM1 and GSTT1 genes, the frequency of both null type of GSTM1/T1 genes was significantly different from both positive type of GSTM1/T1 genes [χ<SUP>2</SUP>=7.6575, p=0.0057, odds ratios (95% confidence intervals)=2.1685 (1.1796∼3.9865)]. These results indicate that the polymorphisms of GST gene may be a susceptibility factor in the development of osteoarthritis in Korean population.