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임대정,임대정,이현진,황지혜,최현석,김경호 대한침구의학회 2006 대한침구의학회지 Vol.23 No.5
목적 : 심박수 변이도(Heart Rate Variability. HRV)를 통해 사암침법 치료법 중 심신 질환에 많이 적용되는 심정격 자침법과 자율신경계와의 관계를 살펴보고자 하였다. 방법 : 2006년 5월 1일부터 2006년 6월 31일까지 2개월간 특별한 과거력이 없는 건강인을 대상으로 실험군 37명을 사암침법 심정격을 자침하고 시술 전후에 HRV를 측정하여 별무처치 상태로 안정을 취한 후 측정한 대조군 21명과 비교하였다. 결과로 얻은 MHRT, SDNN, RMSSD, TP, LF, HF, LF/HF ratio 등의 수치 변화를 비교해 기록 시간 동안의 평균 심박수, 외부 스트레스에 대한 심박동의 변화상태, 심장에 관여하는 자율신경 중 부교감신경의 활동, 교감신경과 부교감신경의 균형 상태 등을 분석하였다. 결과 : 1. MHRT는 실험군에서 유의성이 있는 것으로 나타났다. 2. SDNN는 실험군 대조군 모두 통계적인 유의성이 없었다. 3. RMSSD은 실험군 대조군 모두 통계적인 유의성이 없었다. 4. TP는 실험군 대조군 모두 통계적인 유의성이 없었다. 5. LF, HF은 실험군 대조군 모두 통계적인 유의성이 없었다. 6. LF/HF ratio는 실험군에서 유의성이 있는 것으로 나타났다. 결론 : 부교감신경과 교감신경의 비교 지표로 다용되는 LF/HF ratio가 유의한 차이를 보여 심정격 자침이 자율신경계의 항진을 완화시키는 것으로 사료된다. 향후 환자의 병인과 상태에 따라 실증과 허증으로 구분하여 시술하는 등의 추가적인 연구가 필요할 것으로 사료된다.
紅花子藥鍼의 항염증능이 백서의 LPS로 유발된 류마티스성 관절염에 미치는 영향
임대정,조재용,정웅채,박인식,김갑성,김경호 대한침구의학회 2008 대한침구의학회지 Vol.32 No.4
Objectives : This study is to evaluate Effect of Hong Hua Za acupuncture anti-inflammatory on rheumatoid arthritis that caused by Lipopolysaccharide in mouse. Methods : Hong Hua Za(Carthami Tinctorii Fructus) acupuncture(HA) was prepared and tested for therapeutic potential of rheumatoid arthritis, by measuring the inhibition of inducible nitric oxide synthase (iNOS) expression, nitric oxide(NO) production in vitro experiment, by measuring Tumpr Necrosis Factor- α(TNF-α) & Nuclear Factor kappa B(NF-κB) p65 activation, synovial hyperplasia, angiogenesis and fi- brosis in synovial membrane of knee joint of mice. Results : HA showed therapeutic effects on Lipopolysaccharide(LPS)-induced rheumatoid arthritis. HA inhibited iNOS mRNA and NO in RAW264.7cell of LPS-induced rheumatoid arthritis in a dose dependent manner. HA also showed significant inhibition of TNF-α & NF-κB p65, activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Conclusions : These results suggest that HA has an therapeutic effects on LPS induced-rheumatoid arthritis by inhibiting TNF-α activation.
말초성 안면신경마비환자의 동반질환과 발병원인을 중심으로 한 단면 조사 연구
임대정,이아람,황종순,조현석,김경호,김지용,Lim, Dae-jung,Lee, A-ram,Hwang, Jong-soon,Cho, Hyun-seok,Kim, Kyung-ho,Kim, Ji-yong 대한한방안이비인후피부과학회 2004 한방안이비인후피부과학회지 Vol.17 No.3
Objective: The purpose of this study is to investigate the past history of the patients with peripheral type nerve palalysis. Methods: We examined the age, sex, region, month, season, past disease and cause of 692(343 male, 349 female) patients with peripheral type nerve palalysis who visited Dept. of Acupuncture and Moxibustion, Bundang Oriental Medicine Hospital, Dongguk University, from 2001-10-1 to 2004-9-30. Results: 420 patiens(60.7$\%$) were in the age between 30-59. The region, sex, and seasonal distribution didn't have a remarkable contrasts. In the past disease, Hypertension(14.5$\%$), Diabets mellitus(9.2$\%$), Gastric diseases(3.9$\%$) and Live diseases(3.8$\%$) were investigated highly than other diseases. In the distribution of cause, fatigue(36.3$\%$), unknown(34.8$\%$), stress(19.2$\%$) cold exposure(12.1$\%$) were investigated highly than other causes.
임대정,이현무,최황 대한비뇨의학회 2004 Investigative and Clinical Urology Vol.45 No.1
Purpose: We performed a retrospective study to determine the clinical characteristics and outcome of fetal hydronephrosis. Materials and Methods: The records of the children diagnosed with fetal hydronephrosis between 1990 and 2001 were retrospectively analyzed. In the postnatal follow-up period, the children were followed by sequential ultrasonography and urinalysis. Diuretic renal scanning and voiding cystourethrography were performed in selected cases. The clinical characteristics and outcome were evaluated and compared to the degree of hydronephrosis. Results: The study comprised 341 children with 427 dilated kidneys. Mild (Grade 1), moderate(Grade 2 or 3) and severe(Grade 4) hydronephrosis were present in 21.8%, 60.4% and 17.8% respectively. Hydronephrosis resolved spontaneously in 126(29.5%) kidneys, including 52.7% of mild and 2.6% of severe hydronephrosis. Mean interval to spontaneous resolution was 1.39(±1.41, SD) years. Dilatation of the renal pelvis was caused by primary ureteropelvic junction obstruction in 65.6%, multicystic kidney in 9.4%, vesicoureteral reflux in 7.0%, duplex system in 5.4%, ureterovesical junction obstruction in 4.0%, and posterior urethral valves in 3.0%. Surgery was performed in 174 kidneys, consisting of pyeloplasty in 105, ureteroneocystostomy in 23, transurethral incision in 11, and nephrectomy in 9. Most patients had initially high-grade hydronephrosis (p<0.05). Conclusions: Mild hydronephrosis appears to be relatively benign, and in most cases dilatation improves with time with surgical intervention thereby not required. On the other hand, moderate or severe hydronephrosis often results in a significantly poorer outcome and requires surgical intervention, and hence closer follow-up both antenatally and postnatally. (Korean J Urol 2004;45:29-33)
홍화자약침(紅花子藥鍼)의 항염증능이 백서의 LPS로 유발된 류마티스성 관절염에 미치는 영향
임대정,조재용,정웅채,박인식,김갑성,김경호,Lim, Dae-Jung,Cho, Jae-Yong,Jeong, Woong-Chae,Park, In-Shik,Kim, Kap-Sung,Kim, Gyeong-Ho 대한침구의학회 2008 대한침구의학회지 Vol.25 No.3
Objectives : This study is to evaluate Effect of Hong Hua Za acupuncture anti-inflammatory on rheumatoid arthritis that caused by Lipopolysaccharide in mouse. Methods : Hong Hua Za(Carthami Tinctorii Fructus) acupuncture(HA) was prepared and tested for therapeutic potential of rheumatoid arthritis, by measuring the inhibition of inducible nitric oxide synthase (iNOS) expression, nitric oxide(NO) production in vitro experiment, by measuring Tumpr Necrosis Factor-$\alpha$(TNF-$\alpha$) & Nuclear Factor kappa B(NF-$\kappa$B) p65 activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Results : HA showed therapeutic effects on Lipopolysaccharide(LPS)-induced rheumatoid arthritis. HA inhibited iNOS mRNA and NO in RAW264.7cell of LPS-induced rheumatoid arthritis in a dose dependent manner. HA also showed significant inhibition of TNF-$\alpha$ & NF-$\kappa$B p65, activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Conclusions : These results suggest that HA has an therapeutic effects on LPS induced-rheumatoid arthritis by inhibiting TNF-$\alpha$ activation.
HRV(Heart Rate Variability)를 통한 말초성 안면신경마비와 자율신경실조의 상관성 연구
임대정,황지혜,황종순,조현석,김경호,김갑성 대한침구의학회 2005 대한침구의학회지 Vol.22 No.6
Objectives : This study was designed to evaluate the effect of inbalance of autonomic nerve system on peripheral facial palsy patients in comparison of Heart Rate Variability results of healthy control group with that of peripheral facial palsy group. Methods : The peripheral facial palsy patiens who visited the Dongguk university Bundang oriental medicine hospital from April to June in 2005 were tested Heart Rate Variability items which are Mean Heart Rate(MHRT), Standard Deviation of all the Normal RR intervals(SDNN), Root Mean Square of Successive Differences Between The Normal Heart Beats(RMSSD), Total Power(TP), Low Frequency, High Frequency, ratio between the Low Frequency and High Frequency power(LF/HF ratio). The Heart Rate Variability test results of peripheral facial palsy group were compared with the HRV test results of healthy control group who didn't have nervous disease, musculoskeletal disease, heart problem and pain for the past 6 months. Results : 1. MHRT was not significantly different between peripheral facial palsy group and healthy control group(P=0.18). 2. SDNN was not significantly different between peripheral facial palsy group and healthy control group(P=0.41). 3. RMSSD was not significantly different between peripheral facial palsy group and healthy control group(P=0.93). 4. TP was not significantly different between peripheral facial palsy group and healthy control group(P=0.94). 5. LF and HF were not significantly different between peripheral facial palsy group and healthy control group((P=0.34, 0.30).6. LF/HF ratio was significantly different between peripheral facial palsy group and healthy control group(P=0.04). Conclusion : LF/HF ratio is generally used as autonomic nerve system evaluation and there was significantly statistical difference between peripheral facial palsy group and healthy control group.