체험을 통한 나라사랑교육 활성화 방안

임경남,나태종 한국보훈학회 2016 한국보훈논총 Vol.15 No.2

This study is putting purpose on suggestion that the state agencies must be active for patriotism security experiential education for actively cope with the rapidly changing security environment on the Korean peninsula and North Korea's immediate military threat to overcome. For the study's purpose, we deduct implications by survey connecting theories with activity for experience and look through foreign examples of citizenship training and Korean security experience in educational facilities's present condition and operational condition. The measures of patriotism experience education are to approach in long, middle and short-term level, but we suggest feasible plan on current situation and condition. Researching the results, we deduct that VHS Education and Research Institute is proper, which accomplishes this patriotism experience education. For this, first, they are suitable strategy and strengthen educational program for educational target. Second, they clap up memorandum of understanding and promote with associated local government, education office, reward of exploit organization, army unit etc. Third, they develop patriotism education connected to education of reunification. Finally, they strengthen internal and external evaluation for Department of Education and its development. 본 연구는 급변하는 한반도 안보환경에 능동적으로 대처하고 나라사랑 정신을 함양하기 위해서는 국가기관이 주체가 된 나라사랑 체험교육이 활성화되어야 함을 제시하는데 목적을 두고 작성되었다. 연구목적 달성을 위해 체험활동 및 체험학습과 관련된 이론을 개관하고 외국의 사례와 한국의 체험교육시설 현황 및 운영실태를 검토하였다. 체험을 통한 나라사랑교육 활성화 방안은 장기적인 차원과 중․단기적 관점에서 접근하되, 현재의 상황과 여건에서 실행 가능한 방안을 제시하였다. 연구결과 보훈교육연구원이 주체가 되어 나라사랑 체험교육을 실시하는 것이 타당함을 도출하였다. 이를 위해 첫째, 교육대상에 적합한 학습전략과 교육프로그램을 보완하고, 둘째, 관련 지자체 및 교육청, 보훈단체, 군부대 등과 양해각서를 체결하여 협업을 추진하며, 셋째, 통일교육과 연계한 나라사랑 교육으로 발전시키고, 넷째, 교육성과 제고를 위한 내부평가와 외부평가가 강화되어야 한다.

굴비 외 1편

임경남 고요아침 2022 열린시학 Vol.27 No.3

Salt Stress Responses of an Alanine Aminotransferase Knock-out Mutant of Rice (Oryza sativa L.)

Kyoung-nam Im(임경남),Chin Bum Lee(이진범) 한국생명과학회 2013 생명과학회지 Vol.23 No.4

T-DNA가 표지된 집단에서 AlaAT 유전자가 깨어진 돌연변이체(alaat)를 분리하고, AlaAt1 특이 프라이머를 이용하여 유전자형을 결정하였다. Alaat의 표현형은 대조구와 비교해서 생장의 감소를 보였고, 종자 역시 작고 생산성의 감소를 보였다. 돌연변이체의 AlaAT 활성은 거의 검출되지 않았다. 고염 스트레스 하에서 alaat의 반응을 엽록소 형광과 항산화 효소들의 활성 및 RT-PCR을 이용하여 대조구와 비교하였다. 고염, 건조 및 저온과 같은 모든 비생물적 스트레스에 대한 Fv/Fm은 대조구와 alaat 둘 다 감소를 보였으며, 비생물적 스트레스에 대한 엽록소 형광은 거의 유사하였다. 항산화 효소인 peroxidase (POX)의 활성은 고염 스트레스에 의해 대조구는 증가하나 alaat에서는 오히려 감소하였다. RT-PCR에 의한 cAPX, POX 및 AlaAT mRNA의 수준을 분석한 결과, 효소 활성과 마찬가지로 AlaAt mRNA는 alaat에서 나타나지 않았고, POX2 mRNA는 대조구는 약간의 증가를 보이나 alaat는 거의 검출할 수 없었다. cAPX mRNA는 대조구와 alaat 모두 고염 스트레스에 의해 크게 증가하였다. 이 같은 결과는 AlaAT 유전자 기능의 상실은 염 스트레스 하에서 벼 식물의 생장에 대해 광합성능 보다는 항산화 효소, 특히 POX 활성 및 합성을 변화시킬 수 있음을 제안한다. An AlaAT knock-out mutant (alaat) of rice (Oryza sativa L.) was isolated from T-DNA tagging lines and the genotypes of its progeny were determined with AlaAT1-specific primers. The alaat phenotypes showed decreased growth and grain yield when compared with control plants. The activity of AlaAT1 in the mutant plants was practically undetectable. The responses of alaat plants to growth under salt stress were compared with those of control plants by measuring chlorophyll fluorescence and the activities and mRNA expression of antioxidant enzymes. All abiotic stresses tested (salt, drought, and chilling) caused a similar decrease in chlorophyll fluorescence in both alaat and wild type plants. The activity of peroxidase (POX), an antioxidant enzyme, decreased following salt treatment of alaat plants, while control plant showed an increased activity. The mRNA levels for cAPX (cytosolic ascorbate peroxidase), POX2, and AlaAT were determined by RT-PCR following salt stress. No AlaAT1 mRNA was detected in alaat plants. The POX2 mRNA showed a slightly increased level in the wild type but was not detected in alaat plants, in agreement with the activity assays. The levels of cAPX mRNA were greatly increased in both the wild type and alaat plants. The salt stress effects on rice plant growth are therefore proposed to reflect a loss of function of AlaAT, which alters the activity and synthesis of antioxidant enzymes (especially peroxidases), rather than a direct effect on photosynthesis.

Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data

고경남,한정우,최형수,강형진,이지원,유건희,성기웅,구홍회,홍경택,최정윤,강성한,김혜리,임호준,한승민,유철주,백희조,국훈,박경미,양유진,임영탁,김성구,이재욱,정낙균,조빈,박미림,박현진,박병규,이준아,박준은,김순기,김지윤,김효선,마영은,박경덕,박상규,박은실,심예지,유은선,유경하,유재원,임연정,윤회수,이미정,이재민,전인상,정혜림,최희원,원승현,The Korean 대한암학회 2023 Cancer Research and Treatment Vol.55 No.1

PurposeRenal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea.Materials and MethodsFrom January 2001 to December 2015, data of pediatric patients (0–18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed.ResultsAmong 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range 0-225.5) and median follow-up duration was 88.5 months (range 0-211.6). Overall, 32 patients died, of whom 17, 11, 1, and 3 died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001).ConclusionThe pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.

지하수 모델링을 통한 지하수댐 건설 효과 분석

김지욱,임경남,박현진,이보경,Kim, Ji-Wook,Lim, Kyung-Nam,Park, Hyun-Jin,Rhee, Bo-Kyoung 한국지하수토양환경학회 2013 지하수토양환경 Vol.18 No.3

SEAWAT, a linked modeling program of Visual MODFLOW was used to analyze the change in groundwater levels and salinity related groundwater dam construction in Cheongsan island, Wando-Gun, Jeollanam-Do. The steady-state model results show the groundwater flow and salinity distribution of the studied area. The groundwater flows from north-west and south-east highlands into the river, located in the middle part of the basin, and is eventually discharged to the ocean. Part of the sea water infiltrates into the river; and through the estuary's alluvium aquifer, the sea water intrusion takes place spreading to about 830 m from the ocean. The transient model results show that after the groundwater dam construction, groundwater levels will rise to a maximum of 2.0 m upstream, and the groundwater storage will increase 21,000 after 10 years. Meanwhile 31% of the total area affected by sea water intrusion will decrease. To conclude, the groundwater dam is a very useful method for a secure water resource in preparation for drought and water shortages in the island regions.

쓰가루 사과즙을 이용한 두부의 품질 및 항산화 특성

김동호(Dong-Ho Kim),홍경남(Kyeong-Nam Hong),임여경(Yeo-Kyeong Lim),차승현(Seung-Hyeon Cha),류지은(Ji-Eun Ryu),조진호(Jin-Ho Cho),김대일(Dae-Il Kim),유도일(Do-Il Yoo),장금일(Keum-Il Jang) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.8

본 연구에서는 ‘쓰가루’ 사과즙을 이용하여 제조한 두부의 품질, 항산화 활성 및 관능 특성을 분석하고자 하였다. 두부제조를 위해 사용한 ‘쓰가루’ 사과즙은 60%의 수율, 10.3 °Brix, pH 3.89, 0.51%의 총산을 나타내었고, 총폴리페놀 함량은 2.26 mg GAE/g, ABTS 라디칼 소거능은 20 μg AE/g, DPPH 라디칼 소거능은 75 μg AE/g을 나타내었다. ‘쓰가루’ 사과즙을 첨가하여 두부의 제조가 가능하였으며, 사과즙의 첨가량이 증가할수록 제조된 두부의 수율과 pH는 감소하였으나 총산은 증가하는 경향을 나타내었다. 또한 조직감에서는 경도와 씸힘성이 증가하였으나 응집성은 다소 감소하는 경향을 나타내었으며, 색도에서는 L값이 감소하고 a값과 b값은 증가하여 전반적으로 어두운 갈색을 나타내었다. 이러한 갈색화 반응의 주요 원인은 사과즙의 효소적 갈색화 반응에 기인하므로 비타민 C 등의 환원제, 산미제 및 무기염을 사용하는 방법으로 갈변 방지를 최소화할 수 있을 것으로 생각된다. 그리고 항산화 활성에서는 총폴리페놀 함량과 DPPH 라디칼 소거능이 증가한 반면 ABTS 라디칼 소거능은 일정한 범위를 유지하였다. ‘쓰가루’ 사과즙 첨가량에 따라 제조된 두부의 맛, 색, 풍미, 전체적인 선호도에서 30%(w/v) ‘쓰가루’ 사과즙으로 제조한 두부의 선호도가 가장 높게 나타났다. 따라서 본 연구에서는 ‘쓰가루’ 사과즙으로 제조한 두부의 품질, 항산화 특성 및 관능적 특성을 확인함으로써 ‘쓰가루’ 사과 품종을 이용한 다양한 가공식품의 제조 가능성을 제시하였다고 생각된다. In this study, we investigated the quality, antioxidant properties, and sensory characteristics of tofu coagulated with ‘Tsugaru’ apple (Malus domestica Borkh) juice. Yield, °Brix, pH, total acidity, total polyphenol content, 2,2"-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, and 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging activity of ‘Tsugaru’ apple juice were 60%, 10.3, 3.89, 0.51%, 2.26 mg gallic acid equivalent (GAE)/g, 20 μg L-ascorbic acid equivalent (AE)/g, and 75 μg AE/g, respectively. In case of Tofu coagulated with 20% (w/v) ‘Tsugaru’ apple juice, yield, °Brix, pH, total acidity, hardness, chewiness, cohesiveness, total polyphenol content, ABTS radical scavenging activity, and DPPH radical scavenging activity were 165%, 6.23, 0.27%, 513 g, 315, 0.61, 12.04 mg GAE/g, 80.67 μg AE/g, and 92.32 μg AE/g, respectively. Both the manufacture yield and pH of tofu decreased with increasing amount of ‘Tsugaru’ apple juice, whereas total acidity increased. Regarding the texture and chromaticity of tofu coagulated with increasing amounts of ‘Tsugaru’ apple juice, hardness, chewiness, and a- and b-values increased, whereas cohesiveness and L-value both decreased. In terms of antioxidant activities, total polyphenol content and DPPH radical scavenging activity increased, whereas ABTS radical scavenging activity was maintained within a certain range. Finally, concerning the sensory evaluation (taste, color, flavor, and overall preference) of tofu coagulated with 30% (w/w) ‘Tsugaru’ apple juice showed the highest scores. Taken together, these results support the possible use of ‘Tsugaru’ apple juice in producing various foods, as addition of juice enhanced quality, antioxidant properties, and sensory characteristics of tofu.

제로에너지 타운 - 에너지 자급도p시의 비전

박순철,유창균,백남춘,경남호,임성대,유권종 한국태양에너지학회 2005 한국태양에너지학회 학술대회논문집 Vol.- No.-

Responses of Photosynthetic Efficiency and Ascorbate Peroxidase Induced by Salt Stress in Rice (Oryza sativa L.)

Jeung Suk Koo(구정숙),Kyoung Nam Im(임경남),Hyun-Sik Chun(전현식),Chin Bum Lee(이진범) 한국생명과학회 2010 생명과학회지 Vol.20 No.8

Salt stress가 벼 잎 내 광합성 효율과 ascorbate peroxidase (APX) 활성에 미치는 영향을 조사하였다. 염 농도가 증가(NaCl, 100-300 mM) 할수록 Fv/Fm 값이 감소한 반면, H₂O₂ 양과 APX 활성은 증가하였다. APX isoforms 중 APX 1 (stromal)은 300 mM NaCl 처리 시 활성이 거의 나타나지 않는 반면, chilling이나 drought 처리 시에는 변화가 없었다. 또한 gel 상에서의 서로 다른 APX isoforms의 활성이 유전자 발현에서도 확인이 되는지를 알아보기 위해 RT-PCR을 수행하였다. 구획별 APX isoforms의 RT-PCR 수행 결과, cytosolic/thylakoid bound APX 발현양은 증가한 반면, stromal APX 발현은 매우 감소하였다. 이러한 실험 결과는 salt에 의해 구획별로 APX 활성이 영향을 받음을 나타낸다. We investigated changes in photosynthesis and activity of ascorbate peroxidase (APX) that scavenges ROS as responses to oxidative stress induced by salinity in rice (Oryza sativa L.). Photosynthetic efficiency of rice leaves, monitored in terms of Fv/Fm, declined with the increase of salt concentration (100-300 mM NaCl). Salinity caused an increase of H₂O₂ in leaves of rice, with an increase of APX activity. Among total APX isoforms, an isoform of stromal-APX 1 in leaves of rice was completely inactivated by 300 mM NaCl, but was not affected by chilling or drought. The results suggest that salt stress acts in quite a different mechanism in relation to the activity of stromal-APX from that of other stresses such chilling and drought. We carried out RT-PCR for analysis of genes expression of APX isoforms as affected by salt stress. The expression of cytosolic APX / thylakoid-bound APX genes in leaves of rice exposed to salt stress was increased, while stromal APX gene expression rapidly declined.

Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study

Lee Jae Min,최정윤,홍경택,강형진,신희영,백희조,국훈,김성구,이재욱,정낙균,조빈,조석구,Kyung Mi Park,Eu Jeen Yang,임영탁,Jin Kyung Suh,강성한,Hyery Kim,고경남,임호준,서종진,Hee Won Cho,주희영,이지원,유건희,성기웅,구홍회,박경덕,하정옥,김민경,한정우,한승민,류철주,심예지,김흥식,도영록,유재원,임연정 대한의학회 2020 Journal of Korean medical science Vol.35 No.46

Background: Hodgkin's lymphoma (HL) constitutes 10%–20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to study the epidemiologic features and therapeutic outcomes of HL in children, adolescents, and young adults in Korea. Methods: We performed a multicenter, retrospective study of 224 patients aged < 25 years diagnosed with HL at 22 participating institutes in Korea from January 2007 to August 2016. Results: A higher percentage of males was diagnosed at a younger age. Nodular sclerosis histopathological HL subtype was most common, followed by mixed cellularity subtype. Eighty-one (36.2%), 101 (45.1%), and 42 (18.8%) patients were classified into low, intermediate, and high-risk groups, respectively. Doxorubicin, bleomycin, vinblastine, dacarbazine was the most common protocol (n = 102, 45.5%). Event-free survival rate was 86.0% ± 2.4%, while five-year overall survival (OS) rate was 96.1% ± 1.4%: 98.7% ± 1.3%, 97.7% ± 1.6%, and 86.5% ± 5.6% in the low, intermediate, and high-risk groups, respectively (P = 0.021). Five-year OS was worse in patients with B-symptoms, stage IV disease, high- risk, splenic involvement, extra-nodal lymphoma, and elevated lactate dehydrogenase level. In multivariate analysis, B-symptoms and extra-nodal involvement were prognostic factors for poor OS. Late complications of endocrine disorders and secondary malignancy were observed in 17 and 6 patients, respectively. Conclusion: This is the first study on the epidemiology and treatment outcomes of HL in children, adolescents, and young adults in Korea. Future prospective studies are indicated to develop therapies that minimize treatment toxicity while maximizing cure rates in children, adolescents, and young adults with HL.