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백서의 신경병증성 통증모델의 척수감각신경세포에 대한 NMDA 수용체 길항제 및 NOS 억제제의 영향
이강창(Kang Chang Lee),최유선(Yu Sun Choi),이환봉(Hwan Bong Lee),박승택(Seung Taeck Park) 대한통증학회 2002 The Korean Journal of Pain Vol.15 No.1
N/A Background: In order to evaluate the effect of N-methyl-D-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (APV), nitric oxide synthase (NOS) inhibitor, and aminoguanidine (AGH) on rat spinal sensory neurons from the neuropathic pain animal model. Methods: Cell viability, amount of neurofilament by immunocytochemistry, and rate of protein synthesis were measured after spinal motor neurons of rats were incubated with various concentrations of APV or AGH for 48 hours. Results: Cell viability of spinal sensory neurons from the neuropathic pain model was remarkably decreased compared with the control. Regarding their protective effect, both APV and AGH significantly increased cell viability, amount of neurofilament and rate of protein synthesis, compared to experimental groups with untreated APV or AGH in spinal sensory neurons. Conclusions: The present study suggests that NMDA receptor, reactive nitrogen species (RNS), and No are involved in neuropathic pain.
신승현(Seung Hyun Shin),양빛나(Bin Na Yang),이환봉(Hwan Bong Lee),박동은(Dong Eun Park),채권묵(Kwon Mook Chae) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.4
Purpose: Since the laparoscopic cholecystectomy became an usual procedure, operative indications of the gallbladder polyps have had the tendency to enlarge. There are no precise management plan about the gallbladder polyps which is not included in the accepted operative indications. Therefore a management plan may be required for the patients who has gallbladder polyps which is not accepted operative indications. Methods: We retrospectively analysed 106 patients with gallbladder polyps who were diagnosed preoperatively by ultrasound and CT from January 1991 to January 2005. Our operation indications are polyp above 10 ㎜, symptomatic polyp, sessile polyp, coincidence of stone, focal thickening of gallbladder wall, diffuse wall thickening and detection during other operations. The gallbladder polyps which were suspected to the gallbladder cancer strongly on radiologic studies and polyps above 20 ㎜ size were excluded in this studies. Results: Among the 106 patients, 87 patients underwent operation, and polypoid lesions disappeared during the follow-up period in 3 patients, and 16 patients are on regular follow up. Fifty-six cases received operation with accepted operative indications, and the thirty-one cases underwent operation by the patient’s demand. Two groups showed significant difference in true polyp on pathological diagnosis (P<0.001). There was 16.07% true polyp in opertive indication based 56 patients and no true polyp in patient’s demanded 31 cases. The pathologic diagnoses were cholesterol polyp in 27 patients (87.15%), no polyp in 2 patients, adenomatous hyperplasia in 2 patients. The correlation of the polyp size and pathologic diagnosis was an inverse relation to the polyp size and incidence of pseudopolyp (P=0.014). Conclusion: We propose that the 6-month-interval follow-up observation is fully safe for polyps sized below 10 ㎜ and not included in accepted operative indications.