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RISS 인기검색어
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- 저자 : 이현영 ( Hyun Young Rhee ) (검색결과 2 건)
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유지 혈액투석 환자에서 영양실조-염증 점수와 동맥경화의 연관성
이현영 ( Hyun Young Lhee ),이규백 ( Kyu Beck Lee ),김향 ( Hyang Kim ),정찬희 ( Chan Hee Jung ),이은정 ( Eun Jung Rhee ),이원영 ( Won Young Lee ),김선우 ( Sun Woo Kim ),이영래 ( Young Rea Lee ),최경 ( Kyung Choi ) 대한내과학회 2006 대한내과학회지 Vol.71 No.6
Background: Malnutrition-inflammation complex syndrome (MICS) is common in maintenance hemodialysis (MHD) patients and may be related to a poor outcome. However, there is little evidence showing MICS to be a risk factor for all1erosclerosis. The aim of this study was to determine if MICS is associated will, the atherosclerotic markers such as abdominal aortic calcification (AAC) and pulse wave velocity (PWV) in MHD patients. Methods: Eighty MHD patients were selected in Kangbuk Samsung Hospital (male:female=50:30, age 58±14 years). The nutritional status was assessed by the Subjective Global Assessment (SGA), biochemical measurement and the normalized protein equivalent of the total nitrogen appearance (nPNA). The presence of inflammatory reaction was assessed by the C-reactive protein (CRP). The malnutrition-Inflammation Score (MIS) was used to assess MICS. A lateral lumbar radiogram was used to evaluate the AAC index. Brachial-ankle (ba) PWV using automatic device was performed. Results: Malnourished patients had a higher MIS than the well nourished patients (8.7±3.6 vs. 4.0±1.8, p<0.001). Patients with inflammation (CRP3 mg/L) showed a higher MIS than patients without inflammation (7.6±4.6 vs. 5.7±3.3, p=0.045). There was no correlation between the MIS and the AAC index (r=0.157 p=0.191) and baPWV (r=0.144, p=0.323). Conclusion: These results suggest that the MIS is a useful marker of MICS in MHD patients. However, the MIS was not directly related to the AAC index and baPWV. This report highlights the importance of assessing the MICS and atherosclerosis in MHD patients. (Korean J Med 71:635-645, 2006)
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한국인에서 갑상선기능에 따른 지질 , hsCRP , 허리둔부비와 같은 심혈관질환의 위험인자의 변화
정찬희(Chan Hee Jung),성기철(Ki Chul Sung),신헌섭(Hun Sub Shin),이현영(Hyun Young Lhee),박승하(Seung Ha Park),이호철(Ho Chul Lee),이은정(Eun Jung Rhee),이원영(Won Young Lee),김범수(Bum Soo Kim),강진호(Jin Ho Kang),김선우(Sun Woo Kim) 대한내과학회 2002 대한내과학회지 Vol.63 No.3
Background : Thyroid abnormalities affect a considerable portion of the population. Overt hypothyroidism is associated with an elevated risk of cardiovascular disease and adverse changes in blood lipids. Subclinical hypothyroidism is also associated with an increase risk of cardiovascular disease. So we performed the study to investigate the prevalence of overt and subclinical thyroid disorders and their association between cardiovascular risk factors. Methods : This study was performed in 66,260 subjects (43,588 men, 22,672 women ; between 20∼80 years of age, mean age 41.5±9.6). Serum free thyroxine (FT4), thyroid stimulating hormone (TSH), total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were measured with RIA using commercial kits. High sensitivity C-reactive protein (hsCRP) were measured with nephelometry. Results : The prevalence of overt thyrotoxicosis, subclinical thyrotoxicosis, overt hypothyroidism and subclinical hypothyroidism was 5/1000 (334 subjects), 6.4/1000 (426 subjects), 1.6/1000 (108 subjects), 6.4/1000 (375 subjects) population. Mean plasma total cholesterol and LDL-C were elevated in overt hypothyroidism than normal (202.1 mg/dL and 121.8 mg/dL versus 197.1 mg/dL and 120.1 mg/dL)(p<0.05). Also in subclinical hypothyroidism, mean total cholesterol and LDL-C level were elevated compared to normal group (201.9 mg/dL and 123.7 mg/dL)(p=0.015, p=0.047). Waist-to-hip ratio (WHR) was lower in overt thyrotoxicosis and was higher in hypothyroidism. Conclusion : The prevalence of thyroid dysfunction was not significantly different from those of other countries. It was also age dependent and higher in women but it was lower than expected. Patients with hypothyroidism exhibit higher levels of waist-to-hip ratio as index of obesity. Patients with subclinical hypothyroidism exhibited increased levels of the atherogenic parameters (Total cholesterol, LDL-C). Therefore screening and treatment for subclinical hypothyroidism may be warranted due to the adverse effects on lipid metabolism.(Korean J Med 63:273-282, 2002)
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