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- 저자 : 이해성(Lee Ha Sung) (검색결과 2 건)
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소아 알레르기 환자에서 혈청 흉선과 활동화 조절 케모카인, 대식세포 유래 케모카인의 상승과 호산구 염증지표와의 연관성
정보현 ( Bo Hyun Chung ),이해성 ( Hae Sung Lee ),서현석 ( Hyeon Seok Seo ),박하늘 ( Ha Neul Park ),지그프리드바우어 ( Siegfried Bauer ),서성철 ( Sung Chul Seo ),윤원석 ( Won Suck Yoon ),정지태 ( Ji Tae Choung ),유영 ( Young Yoo ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.4
Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators, but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22 between children with different manifestation of allergic diseases, such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers. Methods: A total of 49 children (14 bronchial asthma, 13 allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels, blood eosinophils and serum eosinophil cationic protein concentrations. Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17 and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases. Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.
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권순철(Kwon Soon Cheol),경갑수(Kyung Kab Soo),김대용(Kim Da Young),이해성(Lee Ha Sung) 대한토목학회 2008 대한토목학회논문집 A Vol.28 No.1A
곡선거더교의 복부는 교축방향의 면내응력과 면외 휨응력을 동시에 받는 구조이므로, 직선교에 비하여 플랜지와 복부의 필릿용접이음부에서의 발생응력이 상당히 크며, 또 바닥틀이나 브레이싱을 주거더에 연결시켜주는 거셋플레이트는 구조적으로 더욱 취약한 구조가 된다. 본 연구에서는 23년간 공용된 곡선거더교에서 발생된 피로균열의 발생원인을 조사하기 위하여 실제교통 흐름 하에서의 용접부에서의 응력특성을 파악하기 위하여 일련의 현장측정을 실시하였다. 이들 현장측정으로부터 여러 가지 타입에 대한 피로균열 원인을 분석하였고, 또한 주요 균열에 대한 피로수명을 평가하였다. 또한 곡선거더교 용접이음부의 구조거동 특성을 조사하기 위하여 유한요소해석을 실시하고 이들 결과를 현장측정결과와 비교분석하였다. The web of a horizontally curved plate girder bridge is, in general, subject to not only longitudinal flexural in-plane stress but also out-of-plane bending stress. Therefore, the induced stresses in the fillet welded joints at the intersection of the web and flange plates in the curved plate girder bridge can be considerably high, and the welded joints of gusset plates connecting the main girder to the floor beams or sway bracings can be subject to much more severe situation than those in the ordinary straight plate girder bridge. In order to investigate the cause of fatigue crack occurred in a curved girder bridge that has been served in about 23 years, in this study, field load tests have been performed to obtain the stress characteristics at the welded joint under the real traffic flow. Using the test results, we have investigated the causes of the occurrence of various fatigue cracks and have estimated the fatigue lives for the cracks. In addition, the characteristics of structural behavior at welded joint of the curved girder bridge have been examined by comparing the FE analysis and the field test result.
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