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      • KCI등재

        과배란유도가 생쥐자궁내막에서의 Tissue Inhibitor of Metalloproteinases-3 및 Matrix Metalloproteinases-9 의 발현에 미치는 영향에 관한 연구

        구승엽(Seung Yup Ku),최영민(Young Min Choi),김연수(Yon Su Kim),이진용(Jin Yong Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6

        N/A Objective : The effects of superovulation on the expression of mRNA and protein of TIMP-3 and MMP-9 in murine endometrium were assessed.Methods : Using murine pregnant uteri of gestation day (g.d.) 4, 5 and 6 after injection of PMSG 5 and 10 IU, the effects of superovulation were assessed and compared with those of natural pregnancy and pseudopregnancy groups using quantitative competitive RT-PCR and immunohistochemical staining.Results : Expression of TIMP-3 mRNA and protein showed an increase in PMSG groups and pseudopregnancy group, while there was no difference in MMP-9 expression between natural pregnancy and PMSG, pseudopregnancy groups on g.d. 4 through g.d. 6. Conclusions : This study suggests that ovarian hyperstimulation by gonadotropin, which produces many oocytes and embryos, may have a detrimental effect on embryonic implantation and its relevant endometrial remodeling process by increase in expression of TIMP-3 in murine endometrium.

      • KCI등재

        한국 폐경여성에서 비타민 D 수용체 유전자 다형성과 골밀도의 연관성

        김정구 ( Jung Gu Kim ),권재희 ( Jae Hee Kwon ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ),이진용 ( Jin Yon Lee ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11

        목적: 한국 폐경여성에서 VDR 유전자 다형성 양상과 골밀도 사이에 연관성이 있는가와 이러한 VDR 유전자 다형성이 혈청 1,25 (OH)2 비타민 D3와 골교체의 생화학적 인자 농도에 영향을 미치는가를 알아보고자 하였다. 연구 방법: 자연폐경여성 433명에서 VDR 유전자내 BsmI, TaqI, ApaI, FokI 제한효소부위의 다형성양상를 PCR과 제한효소 처리 후 나타나는 전기영동 양상으로 분석하고 혈청 CTX, osteocalcin, BAP, 1 Objective: To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women, and to evaluate if VDR gene polymorphisms are associated with serum levels of 1,25 (OH)2 vitamin

      • 아버지의 성 상동형(sex-role stereotype)과 아동의 성 상동형과의 관계연구

        권은정,김연신,노명희,박영미,원경록,이경열,이계숙,이진용,임희진,최여정,최혜영,홍성애 연세대학교 생활과학대학 1987 婦學 Vol.20 No.-

        The purpose of this study was to explore the relationship between the sex-role stereotype of the father and the child. We investigated the following: ⑴ Is there a relationship between the sex-role stereotype of the father and the child? ⑵ Is the age of the child a variable in the relationship between the sex-role stereotype of the father and the child? ⑶ Is the sex of the child a variable in the relationship between the sex-role stereotype of the father and the child? The subjects were 193 13-year-old students attending a middle school in Seoul and their fathers and 70 5-year-olds attending a kindergarten in Kwachon and their fathers. The test for the 193 middle school students and their fathers was the Likert Scale of the Bem Sex-Role Inventory which was utilized by the experimenters after a pretest. The instrument for the 5-year-olds was the 22 story-picture card Williams and Bunnett test(1975) modified by Lee, Sook(1982). The kindergarten fathers were tested with the same instrument as the middle school fathers. The data from these 2 tests were then compared using χ^2 test and percent(%). The result of this study were: ⑴ A relationship between the sex-role stereotype of the father and the child was found only between the sex-role stereotype of the middle school students and their fathers. ⑵ Age of the child was found to be a variable in the relationship between the sex-role stereotype of the father and the child. That is, a significant relationship was found between the sex-role stereotype of the middle school students and their fathers, but not between the sex-role stereotype of the preschool children and their fathers. ⑶ Sex of the child was found to be a variable in the relationship between the sex-role stereotype of the father and the child. That is, a significant relationship was found between the sex-role stereotype of the middle school boys and their fathers, but not between the sex-role stereotype of the middle school girls and their fathers.

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