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이진미,홍석우,김민정,문선준,권혜미,박세은,이은정,이원영 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.1
Background: Dulaglutide, a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA), has been shown to reduce body weight and liver fat content in patients with type 2 diabetes. Family with sequence similarity 3 member A (FAM3A) plays a vital role in regulating glucose and lipid metabolism. The aim of this study was to determine the mechanisms by which dulaglutide protects against hepatic steatosis in HepG2 cells treated with palmitic acid (PA). Methods: HepG2 cells were pretreated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM dulaglutide for 24 hours. Hepatic lipid accumulation was determined using Oil red O staining and triglyceride (TG) assay, and the expression of lipid metabolism-associated factor was analyzed using quantitative real time polymerase chain reaction and Western blotting. Results: Dulaglutide significantly decreased hepatic lipid accumulation and reduced the expression of genes associated with lipid droplet binding proteins, de novo lipogenesis, and TG synthesis in PA-treated HepG2 cells. Dulaglutide also increased the expression of proteins associated with lipolysis and fatty acid oxidation and FAM3A in PA-treated cells. However, exendin-(9-39), a GLP-1R antagonist, reversed the expression of FAM3A, and fatty acid oxidation-associated factors increased due to dulaglutide. In addition, inhibition of FAM3A by siRNA attenuated the reducing effect of dulaglutide on TG content and its increasing effect on regulation of fatty acid oxidation. Conclusion: These results suggest that dulaglutide could be used therapeutically for improving nonalcoholic fatty liver disease, and its effect could be mediated in part via upregulation of FAM3A expression through a GLP-1R-dependent pathway.
이진미,박진명,김지현,이원구,이상훈,남승주,강창돈,이성준 대한췌장담도학회(구 대한췌담도학회) 2019 대한췌담도학회지 Vol.24 No.3
83세 여자 환자가 신장결석으로 입원하여 금식, 세프트리악손 투여 및 경피적 신쇄석술 후 퇴원하였고, 이후 명치 통증이 발생하여 응급실로 내원하였다. 혈액검사 및 복부 전산화 단층촬영에서 담석 및 췌장염 소견을 확인하였고, 담석은 이전에 보이지 않던 소견이었다. 이에 세프트리악손 유발 담석에 의한 급성 췌장염으로 진단하였고 보존적 치료 및 담낭절제술 후 퇴원한 예를 경험하여 보고하는 바이다. Ceftriaxone is commonly used for the treatment of bacterial infection. But it may precipitate in bile causing biliary sludge, pseudolithiasis and gallstone especially in children. We report a case of ceftriaxone-induced acute pancreatitis in an old woman. An 83-year-old woman was admitted for treatment of renal stone. She had received intravenous ceftriaxone for 11 days. After percutaneous nephrolithotomy, she was discharged. After 12 days, she visited the emergency department due to epigastric pain. Laboratory finding was suggestive of gallstone pancreatitis and abdominal computed tomography revealed gallbladder stone, which was absent previously. After conservative care, she received cholecystectomy and discharged without sequelae.
외식업소 경영자의 위생관리 평가분석을 통한 영양사의 지역내 일반음식점 위생교육 지도 필요성 고찰
이진미,이정희,박정숙 대한영양사협회 2003 대한영양사협회 학술지 Vol.9 No.4
The purpose of this study was to examine sanitation management practices of restaurant managers for the training needs &YE&. A total of 26 restaurant managers participated in this study. A check list was consisted of three parts : facility, personal, and food hygiene. Two observers and one manager evaluated the same check list at same time and the results were compared. The results of this study suggested that most restaurants have needed for re-training programs in the view af facility, personal food sanitation practices. Specially, proper washing and sanitizing methods for hands and utensils, proper cooking and holding temperature, and proper storing methods were n&d to be trained. Based on this study, most independent restaurant managers in Cheonan were aware of training, but they had no effective training program manuals. Results of this study implicated that dietitians have new opportunity for consultants of independent restaurants in the region because they have practiced sanitation management manuals.
이진미 대한영양사협회 2001 대한영양사협회 학술지 Vol.7 No.1
The purposes of this study were to: a) examine characteristics of foodservice management practices; b) investigate characteristics of recipients; c) analyze foodservice systems; and d) provide feedback for the efficient and effective foodservice management of mental disorder care sites in Korea. A total of 46 sites was analyzed by questionnaire survey. Statistical data analysis was completed using the SPSS package program for descriptive analysis. As results of site recipients' characteristics, 60% of total sites were males and 40% were female recipients. Average 60% of recipients were from 30 to 40 years old. Major diseases of recipients were mental disorder, high pressure, and obesity. According to the result of foodservice system analysis, the average meal cost per day was about 2,921 won and average food cost percentage was 39%. Average number of meals per day was about 600 meals. All sites had one dietitian and 88.3% of sites had one cook as a full-time employee. In the part of procurement, dietitians were major chargers of sites for purchasing foods. Major purchasing method was the order and delivery contract. About a half of sites used cycle menu system and standardized recipies. Most of sites had recipients' survey systems for evaluating meal satisfaction. About 60% of sites provided liquid diets to recepients and 22% provided diabetic diets. Dietitians at sites had problems on low meal cost budget, lack of cooking professionals, and lack of information about treatment meals for mental disorders for providing higher quality of foods to cure recipients. The results suggested that financial and systematical supports by the government would be very necessary to meet the goal of nutritional balanced meal services.