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한국산 고등 균류의 성분 및 배양에 관한 연구(제55보) : Lyophyllum decastes의 항암 성분 및 배양
이정옥(Chong Ock Lee),김형수(Hyung Soo Kim),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1986 생약학회지 Vol.17 No.1
To find antitumor components of Lyophyllum decastes, the mycelia of L. decastes were cultured in artificial media and a new antitumor component which showed potent antitumor activity against sarcoma 180 implanted in mice, was isolated and named Lyophyllan A. Lyophyllan A was composed of a polysaccharide moiety (86%) and a protein moiety (2%). The polysaccharide moiety was found to be a heteroglycan which consisted of glucose (48.1%), rnannose (30.8%), galactose, xylose and fucose. The protein moiety contained 18 amino acids. Cultural characteristics of L. decastes were investigated by shake culture method. The best result was obtained when L. decastes was cultured in medium glucose 50 g, peptone 10 g, corn steep liquor 30㎖, KH₂PO₄ 0.87 g, MgSO₄·7H₂O 0.5 g, CaCl₂ 0.3 g, FeSO₄·7H₂O 10 ㎎, MnC1₂·4H₂O 7 ㎎, ZnSO₄·7H₂O 4 ㎎ and CuSO₄·5H₂O 1㎎ per one liter at 26℃, 180 rpm, for 9 days.
몇 가지 전이금속, Ni(II), Cu(II) 및 Zn(II) 3,6-bis(2'-pyridyl)pyridazine 착 화합물들의 세포 독성효과
권병목,이정옥,최상운,성낙도,Kwon, Byung-Mok,Lee, Chong-Ock,Choi, Sang-Un,Sung, Nack-Do 한국응용생명화학회 2006 Applied Biological Chemistry (Appl Biol Chem) Vol.49 No.1
6종의 인체 암(폐암, 피부암, 결장암, 자궁암, 선암 및 뇌암)과 그의 17가지 세포주들에 대한 리간드 화합물 3,6-bis(2'-pyridyl)pyridazine(1) 과 3,6-bi s(6'-methyl-2'-pyridyl)pyridazine(2) 그리고 그들의 전이금속(Ni(II), Cu(II) 및 Zn(II)) 착 화합물들 $(3{\sim}6)$ 세포독성을 각각 측정하였다. 그 결과, 특히 Cu(II) 착 화합물, bis-[3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-$k^2N^2,N^3$]chlorocopper(II)perchlorate (4)는 뇌암(SNB-19)과 결장암(SW-62) 세포주에 대하여 제1세대 항암제인 Cis-platin보다 높은 세포독성을 나타내었다. A series of cytotoxic activities $(ED_{50})$ in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2'-pyridyl)pyridazine, 1, 3,6-bis-(6'-methyl-2'-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, $3{\sim}6$ were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis- [3,6-bis-(6'-methyl-2'-pyridyl)pyridazine-$k^2N^2,N^3$]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin.
한국산 고등균류의 성분 연구 (제42보) : 이끼살이애기버섯 및 검정나팔버섯의 항암성분
이경림(Kyung Lim Lee),김혜령(Hye Ryung Kim),이정옥(Chong Ock Lee),정경수(Kyung Soo Chung),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1982 생약학회지 Vol.13 No.4
The carpophores of Xeromphalina campanella and Craterellus cornucopioides which were collected at the Gwang-neung area, Gyeong-Gi Province, in 1981 were studied for their antitumor constituents. The carpophores were extracted with not water and alconol precipitates were obtained. These precipitates were brownish powder which were used as samples in antitumor test. The antitumor activity of each sample was tested against sarcoma 180 implanted subcutaueously in ICR mice. The sample obtained from the carpophores of X. campanella showed the inhibition ratios of 47% and 58% at the dose levels of 20㎎ and 50㎎/㎏/day, respectively. The sample obtained from the carpophores of C. cornucopioides showed no activity. The chemical analysis of the antitumor fraction of X. campanella showed that it contained a polysaccharide. The hydrolysates of the polysaccharide moieties contained five monosaccharides: glucose, galactose, mannose, fucose and xylose.
이승호(Seung Ho Lee),유시용(Shi Yong ryu),최상운(sang Un Choi),노재성(Zaesung No),김성기(Sung Ki Kim),이정옥(Chong Ock Lee),안종웅(Jong Woong Ahn) 한국생약학회 1995 생약학회지 Vol.26 No.1
EtOAc soluble part of MeOH extract of Anemarrhena asphodedoides rhizome was evaluated for the cytotoxicity against the five kinds of human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15) in vitro. Bioassay-guided fractionation of EtOAc soluble part led to the isolation of active compound which was identified as timosaponin A-III showed potent cytotoxic activity, but its genin, sarsasapogenin, did not show cell growth inhibition.