Where is the Mechanistic Target of Rapamycin Signaling Pathway in Depression?

이정안 대한우울조울병학회 2022 우울조울병 Vol.20 No.2

Although the pathophysiology of depression has not been clearly elucidated yet, the mTOR (mechanistic target of rapamycin) signaling pathway has recently taken an increasingly important position in the pathophysiology of depression. In this review, preclinical and clinical studies of depression related to the mTOR signaling pathway will be summarized to explore the current position of mTOR in depression. Because the role of mTOR in the mechanism of the antidepressant effect of ketamine has been attracting attention, related studies will also be reviewed. Summarizing these studies, this review would like to suggest the basis and future direction for treatment and research of depression.

이인석상등병의 전사와 ‘죽음의 정치성’

정안기(鄭安基) 한국일본문화학회 2018 日本文化學報 Vol.0 No.76

The army special volunteer system of colonial Korea has been characterized as an “embarrassing dilemma and mystery” in studies of modern Korean history. This study attempts to reconstruct and reinterpret the death of Corporal Lee In-Seok-the first army special volunteer soldier killed in action-in the context of colonial political history. To do so, it regards the volunteer system as a historical prism for analyzing the political dependence and interactions between colonial authorities and colonized communities. In the 1940s, Corporal Lee was hailed not only as a loyal spirit of the Korean people and a war hero of their troubled nation but also as a symbol of honorable, patriotic sacrifice. He was the first Korean soldier to be killed in battle during the Sino-Japanese War, in which he was engaged under the army special volunteer system. He is known to have died in June 1939, with a shout of “Hurrah for His Majesty the Emperor.” Contrary to popular belief, however, the death of Corporal Lee was neither so glorious nor heroic as to demonstrate his loyalty to the imperial spirit of Japan. Colonial authorities and Korean political forces that were in pursuit of different political ends hailed and idealized him as a Korean war hero fully motivated by imperial Japanese spirit, rather than by Korean national spirit. As a result, Corporal Lee In-Seok, who had lived his life as a humble individual from a remote mountain village in Okcheon, Chungnam Province, was reborn through the politics of death as a symbol for propaganda driving the institutional completion of naeseon ilche-or the “Korea and Japan are one entity” policy-in the 1940s (including conscription, political rights and compulsory education) or as an icon of the J apanization ideology that stimulated the national pride of Korean society.

일반인구에서 자살사고와 혈장 C반응단백 농도의 연관성 : 국민건강영양조사

이정안,박선철,김경미,이봉주,박성우,서미경,이정구 대한우울조울병학회 2018 우울조울병 Vol.16 No.1

Objectives : The purpose of this study is to inquire into the relationship between the association of suicidal ideation and the plasma C-reactive protein level in the general population. Methods : This study selected a total of 5,090 subjects who have responded to the survey item on suicidal ideation status, and received the plasma C-reactive protein test, as a research subject using the 2015 data of the National Health and Nutrition Survey. This study conducted a covariance analysis by correcting a potential influence of demographic and hematological factors. Besides, this study intended to define the cut-off value of the optimum plasma C-reactive protein level, which once identified can distinguish between a subject with and without suicidal ideation using the model of the decision tree. Results : The Plasma C-reactive protein level of a subject having suicidal ideation was noted as being significantly higher than the one having no suicidal ideation in the covariance analysis (p=0.046). In addition, the proper cut-off value of the plasma C-reactive protein level between the subjects with and without suicidal ideation was found to be 1.30 mg/L (p=0.003). Conclusion : It is noted that the high plasma C-reactive protein level showed a significant correlation with individuals with noted suicidal ideation. In addition, this study has significance in that it presented that the plasma C-reactive protein concentration has the possibility as an accurate and significant marker of suicidal ideation in the general population.

포스터 전시 : 신장, 혈액종양 ; 말기 신부전증 환자에서 당뇨병 유무에 따른 빈혈의 차이와 이에 미치는 인자에 관한 연구 2기

이정안,김도형,유수정,오동진,유석희 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10

전태일의 글쓰기 변화과정과 그 의미 - <내 죽음을 헛되이 말라>를 중심으로

이정안 한국현대소설학회 2018 현대소설연구 Vol.- No.72

In the 1970s, a different genre of literature has been salient in Korean literature. Namely, the labors who were in necropolitical labor vividly described how their lives have been exploited. In particular, Jeon Tae-Il’s diaries, letters and memoirs played a vital role in contributing to both arising labor literature and labor memoirs in the 1970s and narrativizing the workers’ rights activists in the 1980s. Do Not Make My Death Futile is the collection of Jeon Tae-Il’s memoirs, letters, and diaries. In the book, it is noticeable that Jeon Tae-Il’s writings were gradually transformed in a distinctive way. To be more specific, while Jeon Tae-Il wrote mainly diaries and memoirs in the early stage of his writings, he wrote letters and a draft for a novel in the late stage. Thus, Jeon Tae-Il writings had been stylistically sophisticated and he had been slowly aware of the readers. Interestingly, Jeon Tae-Il’s biography excludes his diaries about his unrequited love because this kind of diaries would blemish his reputation as workers’ rights activists. From 1969, when he organized Babohoe (literally The Fools), Jeon Tae-Il’s writing was not confined into a private area. Rather, his writing was turned into reader-oriented writing and he was clearly aware of readers. In his letter to Won-Seop, describing a man with driver’s hat, Jeon Tae-Il configured a labor who was in extreme work condition and was estranged from human being’s Gattungswesen (species-essence). By configuring a typical character instead of describing the inner world and private experience, Jeon Tae-Il’s scope of writing was extended. Furthermore, Jeon Tae-Il attempted to revise his memoir by shifting viewpoints on the same event and describing the same event differently. These attempts reflect his desire to dramatize events. While his diary lacks a coherent narrative, his memoir shows an impressive narrativity. The latent desire to the novel in his memoir and his narrative made Jeon Tae-Il write three drafts for novels. In the end, by creating fictional characters and constructing plots, Jeon Tae-Il attempted to write a novel. The transformation of Jeon Tae-Il’s writing can be wrapped up in two aspects: First, the scope of his writing had been gradually extended from private writing to reader-orient writing. Second, his writing evolved into narrative-oriented writing. The reason why Jeon Tae-Il attempted to write a novel seems to be related to the strong social impact of a novel in the 1970s. 1970년대에는 죽음정치적 노동에 종사하던 노동자들이 어떻게 자신의 생명이 착취당하고 있는가를 생생히 기록한 글들이 증가한다. 전태일의 수기와 편지, 일기 등은 1970년대 노동소설, 노동수기의 출현과 1980년대 노동열사 서사에 중추적인 역할을 담당하였다. 전태일의 수기, 편지, 일기 등을 모은 『내 죽음을 헛되이 말라』을 살펴보면 전태일의 글쓰기가 일기, 회상수기, 편지, 소설초안의 순으로 진행됨을 확인할 수 있다. 열병과 같은 짝사랑의 감정을 토로한 전태일의 일기는 노동열사로서 완결된 그의 서사를 약화시킬 가능성이 있었기 때문에 추후 평전에서 제외되게 된다. 사적공간에 남아있던 전태일의 글쓰기는 그가 바보회를 조직하였던 1969년을 기점으로 수신자를 의식한 글쓰기로 바뀌게 된다. 전태일은 원섭에게 보내는 편지에서 운전수 모자를 쓴 사내를 통해 유적 존재를 탈취당하는 노동자의 모습을 형상화하였으며, 이러한 전형적 인물의 형성화는 그동안 일기라는 사적 공간에 머물러있던 전태일의 글쓰기 공간이 확장됨을 시사된다. 또한 같은 내용을 두고 시점과 특정 장면의 연출을 달리하여 다시 쓰기를 시도하고 있는 전태일의 회상수기에는, 사건을 극적으로 ‘보여주고’ 싶어 하는 전태일의 욕망이 드러난다. 서사가 부재하였던 일기와 달리 그의 회상수기는 강한 서사성을 띤다. 전태일의 자기서사 안에 내장되어 있던 소설에 대한 욕망은 그로 하여금 세 편의 소설 초안을 작성하게 만든다. 전태일은 허구적 인물을 창조하고 서사를 구축함으로써 소설쓰기에 도전한다. 이와 같이 전태일의 글쓰기는 독자를 두지 않는 글쓰기에서 청자(독자)를 의식하는 글쓰기이자 서사성을 지향하는 글쓰기로 바뀌어갔다. 전태일의 글쓰기가 점차 소설에 가까운 형태를 취하게 된 이유는, 당시 소설이 사회 전반에 행사하고 있던 막강한 영향력과 관계가 있다.

서평 : 山本有造 저 『「滿洲國」經濟史硏究』

鄭安基(정안기) 만주학회 2005 학술대회 Vol.2005 No.1

사회생태사적 관점에서 본 근대 만주-「만주」의 성립-삼림의 소진과 근대 공간의 형성 -

정안기 만주학회 2011 만주연구 Vol.- No.12

20세기 만주연구의 현황과 과제-『20세기 만주역사 사전』 한일합동 서평 국제회의를 중심으로-

정안기 만주학회 2014 만주연구 Vol.- No.18

준설시기 산정을 위한 하천의 통수능력 평가

정안철(Jeong, An Chul),강태운(Kang, Tae Un),강은비(Kang, Eun Bi),정관수(Jung, Kwan Sue) 대한토목학회 2013 대한토목학회 학술대회 Vol.2013 No.10

식민지 군수동원과 군수회사 체제의 연구-군수회사법의 조선 시행과 운용을 중심으로-

정안기 한일경상학회 2014 韓日經商論集 Vol.63 No.-

The Japanese Government General of Korea in October 1944 initiated a logistics mobilization policy in colonial Korea and designated munitions companies as part of the policy. This study aimed to empirically review the structure and characteristics of the logistics mobilization policy and munitions companies. To begin with, a total of 100 Korean munitions companies designated in the first or second round were listed and analyzed according to their business form, capital system, business line, ethnicity and asset scale. Further, from the perspective of business history, this study considered the realities of logistics mobilization by Korean capitalists such as Park Heung-sik, Shin Yong-wook and Paik Nak-seung among the designated munitions companies. The present work was intended to contribute to the accumulation of empirical studies regarding the history of wartime Korean economy or colonial logistics mobilization regimes. 본 연구는 1944년 10월 식민지 조선에서 조선총독부가 주도하는 군수 동원정책과 이에 대응하는 지정 군수회사의 구조와 특질을 실증적으로 검토하였다. 먼저, 제1-2차 지정 조선 군수회사 100사를 대상으로 회사형태별․자본계통별․업종별․민족별․자산규모별 집계분석을 실시하였다. 또한, 지정 군수회사 가운데 조선인 자본가 박흥식․신용욱․백낙승의 군수동원 혹은 군수협력의 실태를 기업사적 시점으로 구체적으로 검토하였다. 본 연구는 전시기 조선 경제사 연구 혹은 식민지 군수동원 체제와 관련한 실증연구 축적에 기여하고자 하였다.