단순 신장 낭종 경화술 시 배액량과 CT영상 재구성기법을 이용한 낭종의 부피 비교 에탄올 주입량에 관한 연구

이재휘,소형호,주영탁,방상기,이순관 대한인터벤션영상기술학회 2024 대한인터벤션영상기술학회지 Vol.27 No.1

목적: 단순 신장 낭종을 치료하기 위해 우선적으로 고려하는 것이 경피적 에탄올 경화 요법이다. 본 연구의 목적은 정확한 낭종 부피 및 에탄올 주입량을 알아보고자 경피적 에탄올 경화 요법 중 낭종 배액량과 CT 영상재구성기법을 통해 측정한 단순 신장 낭종의 부피를 비교하였다. 대상 및 방법: 본 연구는 2022년 1월 ~2024년 4월까지 단일 세션으로 단순 신장 낭종에 경피적 에탄올 경화 요법을 시행한 환자 28명(남 :23명, 여:5명)의 단순 신장 낭종 31 개를 대상으로 하였다. 단순 신장 낭종 경화 요법 시술 중 배액관을 삽입 후 실제 배액량과 CT 영상재구성기법(Image and Information Management Software Version 11.1 Philips IntellliSpace Portal)을 이용하여 측정한 단순 신장 낭종 부피를 후향적으로 비교 분석하였다. 결과: 경피적 에탄올 경화 요법 시 낭종의 부피는 배액량 평균 131.29±161.62cc, CT 영상재구성기법 평균 146.40±158.95cc 로 측정되었다. 경화 요법 시 주입한 에탄올 양은 배액량 대비 31.33 ±6.73%, CT영상재구성기법 부피 대비 24.14±5.96%로 유의미한 차이가 있었다. 결론: 단순 신장 낭종의 경피적 에탄올 경화 요법 시술 중 실제 낭종의 배액량과 CT영상재구성기법을 이용한 낭종의 부피를 비교 한 결과 시술 중 실제 배액량이 평균 15.11cc ±14.23cc 적게 배액 되었음을 알게 되었다. 이 수치는 경피적 에탄올 경화요법 시행 시 주입해야 하는 정확한 에탄올량을 결정하는 데 영향을 미친다. 주입된 에탄올의 양은 배액량 대비 31.33±6.73%, CT 영상재구성기법으로 측정된 부피 대비 24.14±5.96%로 차이를 보였다. 총 31건의 낭종 중 에탄올 주입량이 최대 100mL 이거나 초과한 4건을 제외한 27건 중 10건에서 낭종 부피 대비 25% 이하의 에탄올 주입량이 확인되었다. 본 연구를 통하여 낭종의 정확한 부피 계산이 가능한 CT 영상재구성기법을 이용하면 경피적 에탄올 경화 요법 시술 시 실제 낭종의 부피와 에탄올 주입량을 큰 오차 없이 결정할 수 있을 것으로 사료된다.

Mechanism of Oxygenation of 2,6-Di-tert-butylphenol Derivative

이재휘,조종인,정석원,함승욱 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.1

한약제의 장관흡수에 관한 생물약제학적 연구(Ⅱ) : 우황이 삼칠인삼 중 조사포닌의 소장흡수에 미치는 영향 Effect of Bezoar on the Small Intestinal Absorption of Crude Saponin in San-Chi Ginseng

이재휘,최영욱,김종갑 중앙대학교 약학연구소 1992 약학 논총 Vol.6 No.-

The influence of bezoar on the small intestinal absorption of crude saponin in the San-Chi ginseng were studied using Schanker's loop circulation method in situ and compared with dissolution rate and partition coefficient in vitro. It was observed that the dissolution of crude saponin in pH 6.5 phosphate buffer solution was enhanced by the addition of bezoar and reached to plateau by 60 min. And small intestinal absorption of crude saponin was also increased proportionally to the amount of bezoar added.

안면부 종창을 동반한 Henoch-Scho¨nlein 자반증 1례

이재휘,서무규,임문환,박성기,김태우,이창연 동국대학교 경주대학 1991 東國論集 Vol.10 No.-

We experienced a case of Henoch-Scho‥nlein purpura with are manifestation of facial swelling in a 7-year-old boy.

쌍강탕(雙降湯)이 고(高)cholesterol 식이(食餌)로 유발(誘發)된 고지혈증(高脂血症) 백서(白鼠)에 미치는 영향(影響)

이재휘,임승민,안정조,조현경,김윤식,설인찬,유호룡,Lee, Jae-Hwi,Lim, Seung-Min,An, Joung-Jo,Jo, Hyun-Kyung,Kim, Yoon-Sik,Seol, In-Chan,Yoo, Ho-Rhyong 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2

Objective : Ssanggang-tang(SGT) is noted as an effective method to treat hyperlipidemia in China. The main purpose of this study was analysis of the effects of Ssanggang-tang(SGT) on rats induced with caused hyperlipidemia. Methods : We observed 3 experimental groups: normal, control, and SGT. Rats were provided a normal diet in the normal group, and the other groups were provided a hyperlipidemic diet to induce hyperlipidemia. After 2 weeks, SGT was treated in the SGT group. For 6 weeks, values related to hyperlipidemia were observed in the 3 experimental groups. Results : SGT decreased some values related to hyperlipidemia like total cholesterol, low density lipoprotein cholesterol(LDL cholesterol), triglyceride, acetocoenzyme A acetyltransferase(ACAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase). However, it showed no effect on weight change or high density lipoprotein cholesterol(HDL cholesterol). Conclusion : These results suggest that SGT might be effective in treatment and prevention of hyperlipidemia.

최신 버전의 Themida가 보이는 정규화가 어려운 API 난독화 분석방안 연구

이재휘,이병희,조상현 한국정보보호학회 2019 정보보호학회논문지 Vol.29 No.6

The latest version of commercial protector, Themida, has been updated, it is impossible to apply a normalized unpackingmechanism from previous studies by disable the use of a virtual memory allocation that provides initial data to be tracked. In addition, compared to the previous version, which had many values that determined during execution and easy to trackdynamically, it is difficult to track dynamically due to values determined at the time of applying the protector. We will lookat how the latest version of Themida make it difficult to normalize the API wrapping process by adopted techniques andexamine the possibilities of applying the unpacking techniques to further develop an automated unpacking system. 최근 상용 프로텍터인 Themida의 최신 버전이 업데이트되면서, 추적할 초기 데이터를 제공하는 가상 메모리 할당을 사용하지 않도록 변경해 기존 연구의 정규화된 대응방안을 적용할 수 없게 되었다. 또한, 실행 중에 결정되는 값이 많아 동적으로 추적하기 수월했던 기존의 버전에 비해, 프로텍터를 적용하는 시점에 결정된 고정값이 많아 동적으로 추적하는데 어려움이 생겼다. API 난독화 과정을 정규화하기 어려워지도록 최신 버전의 Themida가 어떤 방식을채용했는지 알아보고, 이를 해제하는 자동화된 시스템을 추후 개발하기 위해 어떠한 기술을 적용할 수 있을지 가능성을 검토해 본다.

악관절 조영술을 이용한 악관절 장애 환자의 임상적 연구

이재휘 동국대학교 경주대학 1991 東國論集 Vol.10 No.-

This is a retrospective study based on a series of 42 arthrographic examinations of temporomandibular joint in 32 temporomandibular disorder patients following up one year treated as patient at Dept. of Dentistry. Oral & Maxillofacial Surgery, Pohang Hospital, College of Medicine, Dongguk University. The Results obtained were as follows : 1. The mean age of temporomandibular disorder was 31.2 years old, and the ratio of Male/Female was 1 : 22. The first and second decades were the highest age groups in incidence as 59.4%. 2. We could not find any difference of TMJ site in temporomandibular disorder, and the bilateral arthrographic examination was 31.3%. 3. The patients complained temporomandibular pain was 71.9%, and the patients complained headache was 68.8% in clinical symptoms of temporomandibular disorder. 4. In duration of clinial symptoms of temporomandibular disorder, 56.3 could have more than 1 year. 5. In result of arthrographic examinations, MPD Syndrome was 19.0%, Internal Derangement was 81.0%. 6. The first decade was the highest age group in MPD Syndrome, and the second decade was the highest age group in Internal Derangement. 7. As result of arthrogram according to clinical symptoms in temporomandibular disorder, normal arthrogram was high in Group Ⅴ, arthrogram of anterior displacement was high in Group Ⅱ and Ⅳ, arthrogram of perforation was high in Group Ⅶ. 8. The conservative treatment was 59.4%, and the surgical operation was 40.6% in the treatment of temporomandibular disorder. 9. The success rate of conservative treatment was 89.5%, the success rate of arthroscopic surgery was 62.5%, and the success rate of meniscoplasty was 80.0%.

Development of Estimation Methods of Skin Oxidation and Evaluation of Anti-Oxidative Effects of Genistein in Topical Formulations

이재휘,곽지연,구효정 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3

The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formulations were evaluated by determining levels of hydrogen peroxide. The mechanism involved in the determination of hydrogen peroxide is based on a color reaction between ferric ion (Fe3+) and xylenol orange, often called FOX assay and subsequent monitoring of absorbance values of the reactant at 540 nm. The reaction was to some extent pH-dependent and detection sensitivity was greatest at pH 1.75. Genistein liposomal gel demonstrated better anti-oxidative effect with regard to lowering hydrogen peroxide levels elevated by UVB irradiation compared to genistein-suspended gel. A linear relationship has been observed between anti-oxidative effect of genistein and drug deposition in the skin tissue. Genistein liposomal gel resulting in the localization of the drug in the deeper skin led to improved anti-oxidative effect compared to genistein gel. The suggested method for evaluation of oxidation of the skin can be used as a tool to screen effective anti-oxidative agents and their delivery systems acting on the skin.

두부방사선 계측에 따른 한국성인 정상교합자의 최대 교합력에 관한 연구

이재휘,송영복 아주대학교 1997 아주의학 Vol.2 No.1

The purpose of this study was to obtain values of maximum occlusal force after lateral and posteroanterior cephalometric analysis. The normal values of lateral and posteroanterior cephalometric analysis were set up with 118 Korean adults with normal occlusion(63 males and 55 females), and the maximum occlusal forces were measured by occlusal force system(MPM 3000). The results obtained with Korean adults with normal occlusion were as follows; 1) The values of maximum occlusal force were : incisor region 15.1 ㎏ in male and 13.3 ㎏ in female; canine legion 21.2 ㎏ in male and 19.0 ㎏ in female; premolar region 29.5 ㎏ in male and 29.4 ㎏ in female; molar region 48.3 ㎏ in male and 36.2 ㎏ in female. 2) There were significant differences between right and left sides and between male and female in incisor, canine, and molar regions except premolar region(p< 0.05). The maximum occlusal forces in male were significantly greater than in female except premolar region of right side, and they were more stronger in right side than in the left except canine, premolar, and molar regions of male. 3) The lateral and posteroanterior cephalometric measurements representing facial skeletal morphology, particularly mandibular morphology, correlated well with the values of maximum occlusal force in premolar and molar regions(p< 0.05).

악관절의 천공성 전방 관절원판 전위에 관한 연구

이재휘,배정수 東國大學校 1992 東國論叢 Vol.31 No.-

This is a retrospective study by arthrographic, clinical, surgical, and histopathologic examination based on a series of 38 patients, 40 joints having anterior meniscal displacement with perforation of the 278 patients, 336 joints who had diagnosed as TMJ internal derangement by use of TMJ arthrography at department of Oral & Maxillofacial Surgery, Pohang Hospital, College of Medicine, Dongguk University. 1. In the 278 patients, 336 joints who had diagnosed as internal derangement, anterior meniscal displacement with perforation was 11.9% in 38 patients, 40 joints. 2. The false positive finding that occurred by arthrography of anterior meniscal displacement with perforation could be prevented by two times of diagnostic and preoperative with accumulating experience and accurate technique, and arthrography was very valuable in diagnosis of meniscal perforation. 3. The radiographical condyle morphology of anterior meniscal displacement with perforation was all abnormal and small condyle was the highest group in incidence as 40.0%. 4. The ratio of Male/Female in anterior meniscal displacement with perforation was about 1:5, the mean age was 43.6 years old, over 30 years old was 84.3%, and we could not find any difference of TMJ site in meniscal perforation. 5. In the clinical symptoms of anterior meniscal displacement with perforation, crepitus was 94.8%, pain was 73.9%, and limitation of mouth opening was 41.9%. Therefore, we could know that crepitus is diagnostic criterion in meniscal perforation. 6. The mean of preoperative mouth opening in anterior meniscal displacement with perforation was 3.14mm and the mean of postoperative mouth opening was 37.9mm. Therefore, preoperative limitation of mouth opening was largely resolve. 7. In the location of meniscus perforation, posterior attachment was the highest group in incidence as 75.0% and the mean size of meniscal perforation was 6.8mm in diameter. 8. All of anterior meniscal displacement with perforation was treated by surgical operation. The meniscoplasty was 70.0% and the meniscectomy was 30.0%. In the postoperative prognosis, the meniscoplasy was 85.8% in the meniscectomy was 83.3% in success rate. 9. In the histopathologic staging of removed soft tissue of anterior meniscal displacement with perforation, Grade 5 Degeneration was the highest group in incidence as 35.0% and the mean Grade was 4.4 Grade. The Grade 4, 5, 6 Degeneration were 75.0% of all, and so interstitial hyalinization and cartilaginous metaplasia were abundant.