http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
지방산 , 지방 알코올 및 프로필렌글리콜이 클렌부테롤의 경피투과에 미치는 영향
이영대(Yeong Dae Lee),권기철(Qi Zhe Quan),정시영(Si Young Jung),이종달(Jong Dal Rhee),용철순(Chul Soon Yong) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.4
Clenbuterol, a selective β₂-adrenergic receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic bronchitis and pulmonary emphysema. For the purpose of developing a transdermal preparation for clenbuterol, we attempted to select an optimal solvent system and permeation enhancer among fatty acids and fatty alcohols which are known to accelerate the penetration of various drugs in permeation experiments using hairless mouse skin and Franz diffusion cell. Apparent partition coefficient of clenbuterol was increased as pH of buffer solution was increased and solubility of clenbuterol was increased as the percent of propylene glycol(PG) in buffer solution(pH 10) was increased. Permeability of clenbuterol from different buffer(pH 10)/PG solvent mixtures was decreased as the percent of PG in pH 10 buffer solution was increased and among the various enhancers studied, lauryl alcohol was found to be the most effective enhancer, increasing the permeability of clenbuterol approximately 76-fold compared with control. Lauryl alcohol(0∼2%) enhanced the permeability of clenbuterol concentration-dependently. In this study, the optimal solvent system for the penetration of clenbuterol was found to be 50/50 buffer(pH 10)/PG solvent mixture containing 2% lauryl alcohol.
SDSS 자료를 이용한 z<0.01 필드은하의 자외광 특성
이웅,이수창,김석,이영대,박민아,이원형,Lee, Ung,Lee, Su-Chang,Kim, Seok,Lee, Yeong-Dae,Park, Min-A,Lee, Won-Hyeong 한국천문학회 2012 天文學會報 Vol.37 No.2
Sloan Digital Sky Survey (SDSS) DR7 분광자료를 이용하여 z < 0.01에 존재하는 필드(field) 은하 505개를 선별하였다. SDSS의 컬러 영상을 이용하여 필드은하들의 형태(morphology)를 타원은하/왜소타원은하, 렌즈은하/왜소렌즈은하, 나선은하, 그리고 불규칙은하로 분류하였으며, 이들 은하들에 대한 측광을 수행하였다. 한편, Galex Evolution Explorer (GALEX) 자외광 영상으로부터 선별된 은하들에 대한 자외광 측광도 수행하였다. 서로 다른 환경에 있는 은하들의 최근 별탄생 활동이 어떻게 변화하는지 파악하기 위하여 처녀자리은하단 (Virgo cluster)에 있는 은하들과 비교하여 필드은하들의 자외광-가시광 색-등급 분포를 조사하였다. 처녀자리은하단 은하들에 비하여 필드은하들은 작은 자외광-가시광색지수를 가지는 만기형 은하들의 비율이 높았다. 특히, 조기형 필드은하들의 색지수 값이 처녀자리은하단 조기형 은하들에 비해 전반적으로 더 작은 값을 나타내고, 이 특징은 질량이 작은 왜소은하에서 더욱 크게 나타남을 알 수 있었다. 한편, 환경적 효과를 거의 받지 않는 필드은하들은 환경적 효과가 큰 은하단 은하들의 진화 연구에서 환경적 효과의 크기 및 기작을 규명하는 기본 자료로 사용될 수 있음을 토의하고자 한다.
한진혁(Jin-Hyuk Han),이영대(Young-Dae Lee),황도인(Do-in Hwang),김은영(Eun-Yeong Kim) 한국소음진동공학회 2016 한국소음진동공학회 학술대회논문집 Vol.2016 No.4
The Tires, the first parts of the vehicles exposed to the road surface, affect various performances such as the ride comfort, the safety, and the directional stability. Recently, there has been a recent increase of interests in eco-friendly vehicles in accordance with recent environmental regulations, so the factors of fuel efficiency and pass-by noise of the tires are becoming more important. In this paper, we will focus on the method of prediction on radiated noise, affecting pass-by noise, using the suspension and wheels of the vehicles.
지방산, 지방 알코올 및 프로필렌글리콜이 클렌부테롤의 경피투과에 미치는 영향
이영대,권기철,정시영,이종달,용철순 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
Clenbuterol, a selective β_(2)-adrenergic receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic bronchitis and pulmonary emphysema. For the purpose of developing a transdermal preparation for clenbuterol, we attempted to select an optimal solvent system and permeation enhancer among fatty acids and fatty alcohols which are known to accelerate the penetration of various drugs in permeation experiments using hairless mouse skin and Franz diffusion cell. Apparent partition coefficient of clenbuterol was increased as pH of buffer solution was increased and solubility of clenbuterol was increased as the percent of propylene glycol(PG) in buffer solution(pH10) was increased. Permeability of clenbuterol from different buffer(pH 10)/PG solvent mixtures was decreased as the percent of PG in pH 10 buffer solution was increased and among the various enhancers studied, lauryl alcohol was found to be the most effective enhancer, increasing the permeability of clenbuterol approximately 76-fold compared with control. Lauryl alcobol(0-2%) enhanced the permeability of clenbuterol concentration-dependently. In this study, the optimal solvent system for the penetration of clenbuterol was found to be 50/50 buffer(pH 10)/PG solvent mixture containing 2% lauryl alcohol.