위장관 ; 한국인에서 식도손상을 동반한 위식도역류질환의 임상특성: 위험요인을 중심으로

이승준 ( Seung Jun Lee ),정민규 ( Min Kyu Jung ),김성국 ( Sung Kook Kim ),장병익 ( Byung Ik Jang ),이시형 ( Si Hyung Lee ),김경옥 ( Kyeong Ok Kim ),김은수 ( Eun Soo Kim ),조광범 ( Kwang Bum Cho ),박경식 ( Kyung Sik Park ),김은영 ( 대한소화기학회 2011 대한소화기학회지 Vol.57 No.5

Background/Aims: Recent studies suggest that the prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea. However, studies on risk factors for GERD have yielded inconsistent results. The aims of this study were to compare clinical features between symptomatic syndromes without esophageal injury (=non-erosive disease [NED]) and syndromes with esophageal injury (=erosive disease [ED]), and to determine risk factors associated ED. Methods: A total of 450 subjects who visited gastroenterology clinics of six training hospitals in Daegu from March 2008 to April 2010 were consecutively enrolled. The subjects were asked to complete a questionnaire which inquired about gastroesophageal reflux symptoms. The questionnaire also included questions about smoking, alcohol drinking, consumption of coffee, use of drugs, exercise, and other medical history. The subjects were subdivided into NED and ED groups. Results: The proportion of subjects in each NED and ED group was 172 (38.2%) and 278 (61.8%). Male gender, smoking, alcohol drinking, consumption of coffee, large waist circumference, infrequent medication of antacids, aspirin and NSAIDs, infrequent and mild GERD symptoms were all significantly associated with ED on univariate analysis. Age, hiatal hernia, diabetes mellitus, body mass index, change in weight during 1 year, and number of typical GERD symptoms were not independent risk factors for ED. However, the association between ED and alcohol drinking, infrequent medication of antacids, mild typical GERD symptoms remained as strong risk factors after adjustments on multivariate logistic analysis. Conclusions: Independent risk factors associated with ED were alcohol drinking, infrequent medication of antacids and mild typical GERD symptoms. (Korean J Gastroenterol 2011;57:281-287)

지상파 UHD 방송 시스템을 이용한 3D-UHD 방송 서비스의 타당성 분석

이승준(Lee Seung Jun),손인수(Son In Su),박영수(Park Young Soo),이동희(Lee Dong Hee),정경훈(Jung Kyung Hoon),강동욱(Kang Dong Wook) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.6

ATSC 3.0 및 국내 UHD 방송 표준에 의해 제공되는 PLP(Physical Layer Pipe) 기능을 이용하여 지상 UHD 방송 서비스 및 모바일 HD 방송이 서비스되는 경우, 스테레오 영상을 입력으로 하여 부호화하는 CV-SHVC(Cross-View SHVC) 부호화를 통해 효율적인 융합형 3D-UHD 방송 서비스가 가능하다. 이때 좌우 복원 영상의 화질 차이가 상당하여 양안 억제 현상이 나타나는 임계 범위(visibility threshold)를 넘어서는 상황에서는 화질의 비대칭성을 완화하는 기법이 요구된다. 본 논문에서는 SHVC 부호화 기법과 VEI 부호화 기법 및 이 둘을 결합한 방식의 부호화 기법의 비교 실험을 통해, VEI부가정보를 이용한 기법이 상대적으로 우수한 성능을 보이며 3D-UHD 방송 서비스에 적용될 수 있음을 보였다.

일개 병원의 의료인에서 투베르쿨린 검사와 QuantiFERON-TB Gold 검사를 이용한 잠복결핵의 진단과 치료 전후의 변화

이승준 ( Seung Jun Lee ),김현식 ( Hyeon Sik Kim ),마정은 ( Jung Eun Ma ),이상민 ( Sang Min Lee ),함현석 ( Hyun Seok Ham ),조유지 ( Yu Ji Cho ),정이영 ( Yi Yeong Jeong ),김호철 ( Ho Cheol Kim ),이종덕 ( Jong Deok Lee ),김선주 ( Sun 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.4

배경: 결핵의 완전 퇴치를 위해서는 잠복결핵의 진단 및 치료를 통해 활동성 결핵으로 진행되는 것을 예방하는 것이 중요하다. 최근 QuantiFERON-TB Gold 검사가 잠복결핵의 진단을 위한 방법으로 승인되어 사용되고 있다. 본 연구에서는 지역 3차 종합병원에 근무하는 의료인을 대상으로 투베르쿨린 검사와 QuantiFERON-TB Gold 검사를 통해 잠복결핵을 진단하고, 잠복결핵을 치료한 후 투베르쿨린 검사와 QuantiFERON-TB Gold 검사의 변화를 알아보고자 하였다. 방법: 2006년 경상대학교 병원에 근무중인 의료인 중 48명의 지원자(의사 14명, 간호사 34명, 남:여=11:37, 평균연령=29.9±5.5세, 평균근무기간=74.9±64.3개월)를 대상으로 하였다. QuantiFERON-TB Gold 검사와 투베르쿨린 검사를 시행하여 의료인에서 잠복결핵을 진단하고 두 검사의 일치율을 알아보았다. 그리고 QuantiFERON-TB Gold 검사가 양성인 지원자를 대상으로 Isoniazid(INH, 300 mg/day)와 Rifampin(RFP, 600 mg/day)을 3개월간 투약한 후 다시 투베르쿨린 검사와 QuantiFERON-TB Gold 검사를 시행하여 잠복결핵 치료 전후 두 검사의 변화를 확인하고 경결의 양성 기준에 따른 투베르쿨린 검사와 Quanti FERON-TB Gold 검사의 일치율을 알아보았다. 결과: 48명의 지원자 중 투베르쿨린 검사는 경결 양성 기준을 10 mm 이상으로 하였을 때 19명(39.6%)에서 양성, QuantiFERON-TB Gold 검사는 8명(16.7%)에서 양성이었으며 두 검사의 일치율은 77.1%, κ값은 0.468이었고, 투베르쿨린 검사의 경결 양성 기준을 15 mm로 설정하면 두 검사의 일치율은 83.3%, κ값은 0.500이었다. 1명의 활동성 결핵 환자를 제외한 QuantiFERON-TB Gold 검사가 양성인 7명의 지원자에서 잠복결핵 치료 후에도 투베르쿨린 검사와 QuantiFERON-TB Gold 검사는 계속 양성이었다. 이들에게서 시행한 투베르쿨린 검사의 평균 경결은 잠복결핵 치료 전 19.1±9.7 mm, 치료 후 43.6±25.1 mm이었다. 결론: 이번 연구의 결론으로는 투베르쿨린 검사와 QuantiFERON-TB Gold 검사로 잠복결핵의 치료반응을 평가하는 것은 부적절하다고 판단되며 향후 이에 대한 더 많은 연구가 필요할 것으로 사료된다. Background: The QuantiFERON-TB Gold assay and tuberculin skin test (TST) have been useful test for diagnosing latent tuberculosis infections (LTBI). However, there are few reports on the efficacy of the QuantiFERON-TB Gold assay and TST in evaluating the response after the treatment of LTBI. This study examined the changes in the TST and QuantiFERON-TB Gold assay before and after a treatment for latent tuberculosis in health care workers (HCWs) at a local tertiary hospital. Methods: A cohort of volunteers working as nurses and doctors who underwent a TST and QuantiFERON-TB Gold assay was established. The volunteers positive for the QuantiFERON-TB Gold assay had been treated with 3 months of isoniazid (INH) and rifampin (RFP). After completing treatment, the TST and QuantiFERON-TB Gold assay were repeated. Results: Of the 48 participants (14 doctors, 34 nurses, M: F=11:37, mean age=29.9±5.5 years, mean employment period=74.9±64.3 months), 19 (39.6%) tested positive to the TST (mean induration=19.1±9.7 mm) and 8 (16.7%) were QuantiFERON-TB Gold assay. Among them, one had active pulmonary tuberculosis. Seven volunteers were consistently positive to both the TST and QuantiFERON-TB Gold assay after being medicated with INH and RFP for 3 months. Conclusion: TST and QuantiFERON-TB Gold assay are unsuitable for evaluating the treatment response of LTBI because they were consistently positive both before and after the anti-tuberculosis medication. (Tuberc Respir Dis 2007; 62: 270-275)

HCI에 의한 식도염에서 식도와 하부활약근의 점막과 근육세포의 염증변화

이승준(Seung Jung Lee),김창종(Chang Jong Kim),손의동(Uy Dong Sohn),이무열(Moo Yeol Lee),신용규(Yong Kyoo Shin),심상수(Sang Soo Sim) 대한약학회 2002 약학회지 Vol.46 No.1

The underlying mechanism by which the reflux of gastric juice elicits oesophagitis remains unclear. To inverttigate iidlammatory response to HCI in tissue of esophagus and lower esophageal sphincter, experimental esophagitis was elicited by perfusion of 0.1 N HCI in cats. There was no difference in phospholipase A2 (PLA2) activity of tissue between control and esophagitis. Myeloperoxidase activity in esophagitis was significantly greater than that of control. However, his- tamine content in esophageal mucosa of esophagitis was significantly smaller than that of control. These findings suggest that inflammatory response to HCI in esophagitis is related to changes of myeloperoxidase activity and histamine rather than change of PLA2 activity.

시간적 상관도를 활용한 조건부 대체 알고리즘 성능 개선

이승준(Seung-Jun Lee),손인수(In-Su Son),김성훈(Sung-Hoon Kim),정승원(Seong-Won Jung),정경훈(Kyung-Hoon Jung),강동욱(Dong-Wook Kang) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.6

캐비테이션 특성에 미치는 알루미늄 합금의 양극 산화 용액 온도의 영향

이승준 ( Seung Jun Lee ),이정형 ( Jung Hyung Lee ),김성종 ( Seong Jong Kim ) 한국부식방식학회(구 한국부식학회) 2015 Corrosion Science and Technology Vol.14 No.3

The commercialization of aluminum had been delayed than other metals because of its high oxygen affinity. Anodizing is a process in which oxide film is formed on the surface of a valve metal in an electrolyte solution by anodic oxidation reaction. Aluminum has thin oxide film on surface but the oxide film is inhomogeneous having a thickness only in the range of several nanometers. Anodizing process increases the thickness of the oxide film significantly. In this study, porous type oxide film was produced on the surface of aluminum in sulfuric acid as a function of electrolyte temperature, and the optimum condition were determined for anodizing film to exhibit excellent cavitation resistance in seawater environment. The result revealed that the oxide film formed at 10 ℃ represented the highest cavitation resistance, while the oxide film formed at 15 ℃ showed the lowest resistance to cavitation in spite of its high hardness.

해면정맥동을 침범하는 뇌수막종의 치료

이승준(Seung-Joon Lee),한정호(Jung Ho Han),박철기(Chul-Kee Park),김재용(Chae-Yong Kim),백선하(Sun-Ha Paek),김동규(Dong Gyu Kim),정희원(Hee-Won Jung) 대한두개저학회 2008 대한두개저학회지 Vol.3 No.1

OBJECTIVE : We retrospectively analyzed the long-term outcomes in patients with cavernous sinus meningiomas (CSMNGs) treated with the various treatment modalities including surgical resection, radiotherapy, radiosurgery, and clinical observation to find out an optimal strategy in selecting a treatment option. PATIENTS AND METHOD : Of the 77 consecutive patients with CSMNGs treated between 1986 and 2004, 60 were followed up for more than 36 months. Thirty-six (60.0%) patients were female. The mean age of the patients was 52±12 years, and the mean follow-up duration was 83±46 months. The population was divided into four groups including the microsurgery group (n=26, 43.3%), the observation group (n=11, 18.3%), the conventional radiotherapy (CRT) group (n=10, 16.7%), and the radiosurgery group (n=13, 21.7%) according to the initial treatment modality. RESULTS : The actuarial tumor control rates were 84.9%, 78.3%, and 41.8% at 5, 10, and 15 years, respectively. Adjuvant radiation therapy using (CRT) after surgery seemed to be positively associated with tumor control, however it did not reach the statistical significance (p=0.277). The patients treated with CRT or radiosurgery as an initial management also showed better outcome in terms of tumor control, however which was not statistically significant (p=0.138). Tumor progression was observed in 12 patients; 7 (26.9%) of the surgery group, 3 (27.3%) of the observation group, 1 (11.1%) of the CRT group, and 1 (7.7%) of the radiosurgery group. Unfavorable KPS was identified in a total of 13 patients; 7 (26.9%) of the surgery group, 1 (9.1%) of the observation group, 4 (44.4%) of the CRT group, and 1 (7.7%) of the radiosurgery group. Finally, aggravation of the cranial neuropathy mostly developed in 8 (30.8%) patients of the surgery group. Failure of tumor control was negatively related with the outcome of the functional status and the cranial neuropathy after long-term follow-up period. Conclusion : Considering a high rate of tumor progression after long-term follow-up period, CRT and radiosurgery seem to be optimal. However, in terms of the functional status and cranial neuropathy, observation also seems to be an effective modality. Based on our experience, selection of a treatment among various modalities for patients with CSMNGs should be done considering the age of patient, the presence of cranial neuropathy, and the tumor size.

VEI-SHVC 기반 3D 부호화 기술에 관한 연구

이승준(Seung-Jun Lee),이주현,손인수(In-Su Son),김성훈(Sung-Hoon Kim),정승원(Seong-Won Jung),정경훈(Kyeong-Hoon Jung),강동욱(Dong-Wook Kang) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.6

3주간의 주간의 복횡근 강화운동이 만성요통 환자의 요부근력과 통증완화에 미치는 영향

이승준 ( Seung Jun Lee ),이건철 ( Geon Cheol Lee ),배원식 ( Won Sik Bae ),정한신 ( Han Sin Jung ) 대한통합의학회 2013 대한통합의학회지 Vol.1 No.3

Purpose : The purpose of this study was to analyze the effects of transverse abdominal exercise on the change of chronic low back pain and lumbar muscle strength. Method : 18 chronic lumbago patients were transverse abdominal exercise for 3weeks. Result : 1. The strength of the lumbar extensor and flexor of the male subjects was increased significantly after abdominal exercise(p p<<0.05). 2. The strength of the lumbar extensor and flexor of the female subjects was increased significantly after abdominal exercise(p p<<0.05). 3. The study can confirm significant relationship between the lumbar muscle strength and lumbar pain before and after the exercise Conclusion : The study of could find the increase of the ability of the lumbar extensor and flexor of both male and female subjects suffering from chronic low back and pain using three-week transverse abdominal exercise. The study confirmed the general decrease of pain after the experiment.

증례 : 소세포폐암의 항암화학요법 중 종격기종 및 피하기종을 합병한 폐모균증 1예

이승준 ( Seung Jun Lee ),윤석진 ( Seok Jin Yoon ),김은진 ( Eun Jin Kim ),차승익 ( Seung Ick Cha ),박재용 ( Jae Yong Park ),정태훈 ( Tae Hoon Jung ),김창호 ( Chang Ho Kim ) 대한내과학회 2007 대한내과학회지 Vol.72 No.5

폐모균증은 주로 혈당조절이 불량한 당뇨병 및 혈액종양 환자에서 발생하는 드문 곰팡이성 기회감염 질환으로 소세포폐암과 같은 고형암에서의 보고는 극히 드물며, 종격동으로 형성된 누에 의해 종격기종 및 피하기종이 합병된 예는 없었다. 저자들은 소세포폐암으로 항암화학요법을 시행하던 중 침윤의 형태로 시작하여 공동성 경화로 진행되는 양측성 폐모균증을 진단하고, 전신적 amphotericin B를 사용한 후 임상적 호전을 보인 환자에서 2.4개월 지나 폐암의 진행으로 항암화학요법 재투여에 따른 폐모균증 공동의 악화로 누 형성과 함께 종격기종 및 피하기종이 합병되어 폐절제술을 시행하였으나, 진균성 패혈증으로 사망한 1예를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. Pulmonary mucormycosis is an uncommon fungal opportunistic infection found mainly in immunosuppressed patients or in patients with poorly controlled diabetes mellitus. A case of pulmonary mucormycosis complicated by pneumomediastinum and subcutaneous emphysema in small cell lung cancer has not yet been reported to date. A 61-year-old patient with a small cell lung cancer was in a course of clinical improvement with chemotherapy until the development of new bilateral lung lesions after the fourth round of chemotherapy. After diagnosing mucormycosis by a transbronchial lung biopsy of the new lesions, the condition of the patient improved with amphotericin B treatment, but radiographic cavitations of mucormycosis persisted. After 2.4 months of administering oral itraconazole medication, additional chemotherapy was performed due to cancer progression. Mucormycosis developed complicated by pneumomediastinum and subcutaneous emphysema, which resulted from fistula formation of the cavity lesion of the left side into the mediastinum. The patient died of a fungal sepsis despite a surgical resection of the left lesion. (Korean J Med 72:551-557, 2007)