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Inhibition of LFA-1/ICAM-1-mediated Cell Adhesion by Stilbene Derivatives from Rheum undulatum
이승웅,노문철,Byung Soon Hwang,Mi-Hwa Kim,박찬선,이우송,오현미 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.10
Six stilbenes were isolated from the methanol extract of Rheum undulatum rhizomes by bioactivity-guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H-, 13C-NMR and MS), to be desoxyrhapontigenin (1), rhapontigenin (2), trans-resveratrol (3), piceatannol (4), piceatannol-3'-O-β-D-glucopyranoside (5) and isorhapontin (6). Compounds 1-4 inhibited the direct binding between sICAM-1 and LFA-1 of the THP-1 cells in a dose-dependent manner with IC50 values of 50.1, 25.4, 33.4 and 45.9 μM, respectively. On the other hand, the other compounds 5 and 6 with a glucose moiety in each molecule did not show any inhibitory activity in the cell adhesion assay (IC50 values of >100.0 μM). Compounds 2, 3 and 4 also had an inhibitory effect on direct binding between sVCAM-1 and VLA-4 of THP-1 cells. This suggests that the stilbenes from Rheum undulatum rhizomes are good candidates for therapeutic strategies towards inflammation.
Alkamides from Piper longumand Piper nigrum as Inhibitors of IL-6 action
이승웅,Myo Sun Kim,Mi Hye Park,Su-Jin Park,이우송,Jong Sun Chang,노문철 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.4
Blocking of IL-6 has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine the potential effects of alkamides isolated from P. longum and P. nigrum on IL-6 induced Stat3 activation and identify the structure-activity relationship of these alkamides in human hepatoma cells. Among 10 alkamides isolated from P. longum and P. nigrum, compounds 6, 7 and 9 were identified as strong inhibitors of IL-6 action, which inhibit IL-6 induced Stat3-dependent luciferase activities. These inhibitory activities were positively influenced by the presence of piperidine moiety.
Diacylglycerol Acyltransferase에 대한 생약자원의 저해활성 검색
이승웅,고정숙,권오억,이상명,김영호,노문철,김영국,이현선,Lee, Seung-Woong,Ko, Jung-Suk,Kwon, Oh-Eok,Lee, Sang-Myung,Kim, Young-Ho,Rho, Mun-Chual,Kim, Young-Kook,Lee, Hyun-Sun 한국생약학회 2001 생약학회지 Vol.32 No.3
The inhibitory effects of methanol extracts of 135 medicinal herbs on diacylglycerol acyltransferase (DGAT) activity were investigated. DGAT was partially purified from rat liver. Eleven kinds of methanol extracts of medicinal herbs including Evodiae Fructus showed a mild inhibitory effect with the concentration of $125\;{\mu}g/ml$ (above 40% inhibition). Six kinds of methanol extracts including Ephedrae Herba exhibited a weak inhibition. Among them, three kinds of butanol extracts (Sophorae Radix, Arecae Semen, Caesalpiniae Lignum) and the chloroform extracts of Evodiae Fructus showed significant inhibitory activities (above 60% inhibition) at the same concentration.
Inhibition of VLA-4/VCAM-1-mediated Cell Adhesion by Triterpenoid Saponins from Bupleurum falcatum L
이승웅,Min Seok Kim,Ju-Hwan Lim,Jong Sun Chang,Jin Ling,배기환,이우송,노문철 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
Discovery and isolation of compounds capable of blocking the interactions between VCAM-1 and VLA-4, a major pair of adhesion molecules contributing to the different steps of leukocyte migration across the endothelium in inflammatory responses, has been a major goal of this lab. Through bioactivity-guided fractionation, five saikosaponins were subsequently isolated from the methanol extracts of the roots of Bupleurum falcatum L. Their structures were elucidated by spectroscopic analysis (1H-, 13C-NMR and 2D-NMR), as follows, saikosaponins: A (1); D (2); C (3); B3 (4); B4 (5). Compounds 1 and 2 inhibited interaction of sVCAM-1 and VLA-4 of THP-1 cells with respective IC50 values of 7.8 and 1.7 μM. The aglycone structure of 2 also showed cell adhesion inhibitory activity with an IC50 value of 21.1 μM. With these results, we suspect these two saikosaponins from the Bupleurum falcatum L. roots to be prime candidates for therapeutic strategies towards inflammation.
이승웅,한재석,임현식,WonChel Choi,박영신,윤석범 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.11
We have investigated an effective method to control the diameter and the density of carbon nanotubes (CNTs) by introducing a catalyst-embedded supporting layer (CSL) prepared by using rf-magnetron sputtering with a mixed target consisting of Fe and Al2O3. The type of CNTs was changed from single-walled CNTs with a diameter of 0.85 1.55 nm to multi-walled CNTs with increasing rf-magnetron sputtering power. The controllability of the diameter and the density of the CNTs was confirmed to have been improved by using the rf power during the sputtering of the CSL and the concentration of Fe in the mixed target, respectively.