혈소판유래성장인자를 함유한 Chitosan/Calcium Metaphosphate의 골조직재생효과에 관한 연구

이승열,설양조,이용무,이주연,이승진,김석영,구영,류인철,한수부,최상묵,정종평,Lee, Seung-Yeol,Seol, Yang-Jo,Lee, Yong-Moo,Lee, Ju-Yeon,Lee, Seung-Jin,Kim, Suk-Young,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Choi, Sang-Mook,Chung, Chong-Pyou 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1

Chitosan is biodegradable natural polymer that has been demonstrated its ability to improve wound healing, and calcium metaphosphate(CMP) is a unique class of phosphate minerals having a polymeric structure. In this study, chitosan/CMP and platelet derived growth factor(PDGF-BB) loaded chitosan/CMP sponges were developed, and the effect of the sponges on bone regeneration and their possibility as scaffolds for bone formation by three-dimensional osteoblast culture were examined. PDGF-BB loaded chitosan/CMP sponges were prepared by freeze-drying of a mixture of chitosan solution and CMP powder, and soaking in a PDGF-BB solution. Fabricated sponge retained its 3-dimensional porous structure with $100-200\;{\mu}m$ pores. The release kinetics of PDGF-BB loaded onto the sponge were measured in vitro with $^{125}I-labeled$ PDGF-BB. In order to examine their possibility as scaffolds for bone formation, fetal rat calvarial osteoblastic cells were isolated, cultured, and seeded into the sponges. The cell-sponge constructs were cultured for 28 days. Cell proliferation, alkaline phosphatase activity were measured at 1, 7, 14 and 28 days, and histologic examination was performed. In order to examine the effect on the healing of bone defect, the sponges were implanted into rat calvarial defects. Rats were sacrificed 2 and 4 weeks after implantation and histologic and histomorphometrical examination were performed. An effective therapeutic concentration of PDGF-BB following a high initial burst release was maintained throughout the examination period. PDGF-BB loaded chitosan/CMP sponges supported the proliferation of seeded osteoblastic cells as well as their differentiation as indicated by high alkaline phosphatase activities. Histologic findings indicated that seeded osteoblastic cells well attached to sponge matrices and proliferated in a multi-layer fashion. In the experiments of implantation in rat calvarial defects, histologic and histomorphometric examination revealed that chitosan/CMP sponge promoted osseous healing as compared to controls. PDGF-BB loaded chitosan/CMP sponge further echanced bone regeneration. These results suggested that PDGF-BB loaded chitosan/CMP sponge was a feasable scaffolding material to grow osteoblast in a three-dimentional structure for transplantation into a site for bone regeneration.

건강코너 - 임플란트, 유지 관리가 더 중요하다.

이승열,Lee, Seung-Yeol 대한산업안전협회 2003 안전기술 Vol.66 No.-

Marfan증후군의 수술 교정 1례

이승열,남영수,김형묵,Lee, Seung-Yeol,Nam, Yeong-Su,Kim, Hyeong-Muk 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.1

Pectus excavatum occasionally occurs in patients who have underlying cardiac disease, especially Marfan syndrome. This report describes a patient with pectus excavatum who had ascending aortic aneurysm with aortic regurgitation and anterior leaflet prolapse of mitral valve. This patient underwent replacement of aortic valve and ascending aorta with 25 mm SJM valved conduit graft[Bentall operation with Cabrol shunt , and mitral valve replacement with SJM 31 mm, the pectus excavatum was corrected at the time of completion of the intracardiac operation with the modified sternal turnover. This procedure offered excellent operative exposure for the inracardiac operation with prevention of low cardiac output after operation due to depressed sternum and maintained chest wall stability resulting good cosmetic chest wall appearance. This patient recovered and discharged in good postoperative result with minimal temporary peroneal nerve palsy in his left leg.

메타물질과 메타표면 광학 기술

이승열,Lee, Seung-Yeol 한국전기전자재료학회 2016 전기전자재료 Vol.29 No.9

중족골통에서의 소족지 중족 절골술

이승열,정진화,Lee, Seung-Yeol,Chung, Jin-Wha 대한족부족관절학회 2017 대한족부족관절학회지 Vol.21 No.3

Metatarsalgia means the pain under the lesser metatarsal heads. The many causes of metatarsalgia can be categorized into three groups: local disease in the region, altered forefoot biomechanics, and systemic disease affecting the region. Surgical options need to be considered if nonsurgical treatment fails. The metatarsal osteotomies are designed primarily to reduce the weightbearing forces on the metatarsal head by elevating or shortening the metatarsal. Many lesser metatarsal osteotomies have been described, and their success depends on many factors. Regardless of the method employed, it is important to maintain or restore the metatarsal cascade to maintain an even pressure under the lesser metatarsal heads and prevent transfer lesions. The surgeon must understand the effects of the metatarsal osteotomy on the forefoot patho-biomechanics and decide, using a combination of clinical examinations and imaging, whether the desired effect of the osteotomy is to shorten or elevate the metatarsal head or both.

커튼월 설치 로봇 컨트롤러의 설계 및 사용성 평가에 관한 연구

이승열,석재혁,한정완,김병화,한창수,Lee, Seung-Yeol,Seok, Jae-Heuck,Han, Jung-Wan,Kim, Byung-Hwa,Han, Chang-Soo 대한인간공학회 2006 大韓人間工學會誌 Vol.25 No.4

A construction robot has been developed for higher productivity and better safety in various construction fields. Especially, curtain wall is suitable for outer wall material of tall commercial building and apartment complexes. This heavy material is, however, hard to install with a manpower and outdated equipment. For this reason, the prototype of ASCI (Automation System for Curtain wall Installation) was developed. This system has a robot controller(i.e. hand-held remote control unit) for the transfer information signal between human operator and robot system. Although study has been conducted on manual controller of ASCI, hardly any information is known about the operator's opinion. In this study, a questionnaire was completed by operator to get their opinion about aspects which need to design a more comfortable and productive manual controller of construction machinery, robot included. Through the result of study, it is expected that this technical data is contributed to the robot controller design for comfort and productivity of various industrial machinery.

디지털 홀로그램 영상을 위한 차세대 공간 광변조 장치 기술

이승열,김용해,조성목,김태엽,황치영,황치선,Lee, Seung-Yeol,Kim, Yong-Hae,Jo, Seong-Mok,Kim, Tae-Yeop,Hwang, Chi-Yeong,Hwang, Chi-Seon 한국정보디스플레이학회 2017 인포메이션 디스플레이 Vol.18 No.2

천수근 약침을 이용한 퇴행성 슬관절질환 치험 1례

이승열,김희정,배상은,김흥수,이진호,하인혁,김철수,Lee, Seung-Yeol,Kim, Hee-Jung,Bae, Sang-Eun,Kim, Heung-Su,Lee, Jin-Ho,Ha, In-Hyuck,Kim, Chul-Su 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.2

Objectives : The purpose of this clinical case is to evaluate the efficacy of Harpagophytum radix. Pharmacopuncture on Degenerative diseases of knee joint. Methods : We used Korean Medicine treatment and Harpagophytum radix. pharmacopuncture, for this patients. This case is measured and assessed by Neumerical Rating Scale(NRS), Korea Western Ontario MacMaster Universities Osteoarthritis Index(KWOMAC) and Physical examination of knee joint. Results : The NRS decreased from 8 to 5(Left knee joint) & 5 to 4(Right knee joint) and KWOMAC total points decreased from 77 to 41. Also Physical examination of knee joint improved. Conclusions : Harpagophytum radix. pharmacopuncture with Korean Medicine treatment is proved to be helpful to the pain relief and function recovery of knee joint.

무선통신을 이용한 주행 제어가 가능한 볼 로봇의 설계 및 제어

이승열(Seung-Yeol Lee),정명진(Myung-Jin Chung) 한국전기전자학회 2019 전기전자학회논문지 Vol.23 No.4

최근 로봇 기술의 발전에 따라 모바일 로봇에 대한 연구가 주목을 받고 있다. 현재 모바일 로봇의 대부분은 2륜 및 4륜 기반으로 개발되어 직선 주행에는 강하지만 방향전환 및 제자리 회전에 제한이 있으며, 이러한 문제점을 극복하고자 구 형태의 바퀴를 사용하는 볼 로봇에 대한 연구가 진행되고 있다. 볼 로봇은 협소한 공간에서 큰 제약 없이 이동이 가능하다는 장점을 가지고 있지만, 구조적으로 불안정하여 안정적인 자세 및 주행 제어가 요구된다. 본 연구에서는 무선통신으로 자세 및 주행제어가 가능한 스마트폰 어플리케이션을 제안하고, 이를 적용하여 제작된 볼 로봇을 이용하여 자세 및 주행 제어 실험을 수행하였다. 실험을 통해 Roll 각도 오차 ±0.8도, Pitch 각도 오차 ±0.7도 이내에서 제어됨을 확인하였으며, 1m 주행제어에 대해 x축 방향 위치오차 ±0.1m, y축 방향 위치오차 ±0.08m 이내에서 제어됨을 확인하였다. Recently, according to improvement of robot technology, research for mobile robot is increasing. Mobile robot having 2-wheels or 4-wheels is easy for straight driving but is difficult for direction change and rotation. So, ball robot having one contact point with base is interested by researchers. By characteristics of the one contact, ball robot is required the balancing and driving control. In this paper, smart phone application, which is usable for control by wireless communication, is proposed. The ball robot having the proposed smart phone application is designed and manufactured. Balancing and driving control by wireless communication is conducted. From the test, it is conformed that ball robot has the control performances as roll angle error is ±0.8deg, pitch angle error is ±0.7deg, x-axis position error is ±0.1m, and y-axis position error is ±0.08m for 1m driving control.

무선네트워크에서 스위칭 에이전트를 이용한 웹-캐시 멀티미디어 서비스

이승열(Seung-Yeol Lee),김익수(Ik-Soo Kim) 한국정보기술학회 2011 Proceedings of KIIT Conference Vol.2011 No.5

본 논문은 무선네트워크 내에서 스위칭 에이전트(Switching Agent)를 이용한 웹-캐시 멀티미디어 데이터 전송방식을 제안한다. 기존의 무선네트워크에서 모바일 노드(Mobile Node)들은 미디어 서버(Media Server)에 저장되어 있는 멀티미디어 데이터를 엑세스 포인트(Access Point)를 통하여 이용한다. 따라서 사용자가 증가하면 엑세스 포인트 부하 증가가 발생하고, 한정된 네트워크 자원으로 인하여 서비스 품질 저하를 초래한다. 본 논문에서 제안하는 방식은, 무선네트워크 내의 다수의 엑세스 포인트 캐시와 모바일 노드 캐시에 멀티미디어 데이터를 저장하고, 저장된 멀티미디어 데이터에 대한 정보를 스위칭 에이전트가 관리하여 다른 무선네트워크 내에 존재하는 멀티미디어 데이터를 이용하는 방식이다. 또한, 애드혹(Ad-Hoc) 방식을 적용하여 1-hop내의 모바일 노드 캐시에 저장되어 있는 멀티미디어 데이터를 이용하여 엑세스 포인트의 부하를 최소화 할 수 있으며, 서비스 지연을 줄일 수 있다. In this paper, we propose the transmission method of multimedia data using web-cache and switching agent. In existing wireless network, mobile nodes use the multimedia data that stored in media server through access point. Therefore, it occurs the increase of access point load when user increasing, and it is due to the limited network resource causing the deterioration of service quality. The proposed method in this paper, it stores many of access point cache and mobile node cache with the multimedia data in wireless network, it manages the information of storing multimedia data by switching agent, and it uses the multimedia data to stored in other wireless network. Also, it applies the Ad-Hoc method, it minimizes load of access point using the multimedia data to store in 1-hop range of the mobile node, and it can reduce service delay.