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포스터 발표 - 고분자공업분과 : 생체분해성 Poly ( DL - lactide - co - glycolide ) 랜덤공중합체 Micelle 에서 약물방출 (Ⅱ)
이동병,차월석,박영훈,김명렬,나재운,김종균 ( Dong Byung Lee,Wol Suk Cha,Yung Hoon Park,Myung Yul Kim,Jae Woon Nah,Chong Kyun Kim ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1990 No.3
N/A The lineary release time according to the kinds of micelles prepared in the ratio 20:20 of DL-PLGA(70:30, 80:20, 90:10) and clonazepam was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLGA (90:10). Amount of drug release according to the kinds of micelles was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLEA (90:10). Homopolymers were not suited for drug carriers because drug release of poly DL-lactide was too delayed and poly glycolide shows the burst effect in early days.
생체분해성 Poly ( DL - lactide - co - glycolide ) 랜덤공중합체 Micelle 에서 약물방출 (Ⅱ)
이동병,차월석,박영훈,김명렬,나재운,김종균 ( Dong Byung Lee,Wol Suk Cha,Yung Hoon Park,Myung Yul Kim,Jae Woon Nah,Chong Kyun Kim ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1997 No.0
N/A The lineary release time according to the kinds of micelles prepared in the ratio 20:20 of DL-PLGA(70:30, 80:20, 90:10) and clonazepam was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLGA (90:10). Amount of drug release according to the kinds of micelles was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLEA (90:10). Homopolymers were not suited for drug carriers because drug release of poly DL-lactide was too delayed and poly glycolide shows the burst effect in early days.
나재운,이동병,조종수,정영일,김성호,김성현,Nah, Jae Woon,Lee, Dong Byung,Cho, Chong Su,Jeong, Young Il,Kim, Sung Ho,Kim, Sung Hyun 대한화학회 1998 대한화학회지 Vol.42 No.1
DL-lactide와 glycolide로부터 공중합체 Poly(DL-lactide-co-glycolide)(80:20)를 합성하였다. 합성된 공중합체에 소수성 약물인 clonazepam을 함유하는 미소구체를 제조하여 약물전달시스템 제제로서 응용 가능성을 고찰하였다. 미소구체로부터 약물방출실험은 pH 7.4 phosphate buffer solution $37.0{\pm}0.05^{\circ}C$에서 시행하였다. 미소구체로부터 약물이 선형적으로 방출된 시간범위는 고분자와 약물의 무게비가 20:40(mg)인 경우는 51일 이었고, 20:20과 40:20 (mg)의 비율의 경우는 각각 41일, 29일로 미소구체 제조시 약물의 비율이 증가함에 따라 방출시간 또 한 길어짐을 알 수 있다. 결론적으로 본 실험의 diafiltration법에 의해 균일한 크기의 미소구체를 제조할 수 있었으며, 약물은 조절 방출형 pattern을 보여 약물전달시스템 제제로의 응용 가능성을 알 수 있었다. Poly(DL-lactide-co-glycolide) (80:20) was synthesized from DL-lactide and glycolide, and the copolymers was made to micelles containing clonazepam for drug delivery system. The release experiments of the drug from micelles were operated at pH 7.4 phosphate buffer solution $37.0{\pm}0.05^{\circ}C$. The linearly-releasing time ranges of the drug from micelles prepared with the copolymer/drug weight ratio of 20:40, 20:20, and 40:20 (mg) were 50, 41, and 29 days, respectively. So the linearly-releasing time of drug showed the order of micelles 20/40 > micelles 20/20 > micelles 40/20. In short, the formulation allows polymeric micelles to suppress the burst effect of the drug release mechanism, which led to the controlled release pattern and the possibility of drug delivery system for veinous injection.
차월석,김선일,이동병,나재운 ( Wol Suk Cha,Sun Il Kim,Dong Byung Lee,Jae Woon Na ) 한국공업화학회 1995 공업화학 Vol.6 No.1
약물 전달체에 prednisolone을 분산시켜 제조한 고분자 매트릭스를 pH 1.2 및 pH 7.4 완충용액에서 약물 방출실험을 하였다. 약물 방출시간은 pH 1.2보다 pH 7.4에서 더 지연되었으며 약물 전달체의 함유량이 증가함에 따라 약물 방출시간도 지연되었다. 이러한 거동은 약물 전달체가 산성에서 팽윤을 더 잘하기 때문이다. 약물 전달체의 종류에 따라 지연된 약물 방출시간은 키토산 고분자 매트릭스의 경우가 가장 길었으며, 술폰화키토산 고분자 매트릭스, 키토산·염고분자 매트릭스의 순서였다. 특히 이러한 제형들은 초기 방출속도를 억제하는 팽윤성 방출조절형 제제임을 화인할 수 있었다. The release experiments of drug were operated in the buffer solutions of pH 7.4 and pH 1.2 by using drug carriers with prednisolone for delivery drug. The release time of drug was more delayed in pH 7.4 than in pH 1.2. The reason is that drug carriers have greater swelling abilities at low pH than at high pH. The release time of drug carriers was delayed in the order of chitosan polymeric matrix, sulfonated chitosan polymeric matrix, and chitosan hydrochloride polymeric matrix. In short, the fomulation allows polymeric matrix to supress the burst effect of the drug release mechanism, which led to the controlled release pattern by swelling.
Poly(DL-lactide-co-glycolide) 를 이용한 미소구체의 제조
나재운(Jae Woon Nah),이동병(Dong Byung Lee),조종수(Chong Su Cho),정영일(Young Il Jeong),박영훈(Yung Hoon Park) 한국화학공학회 1997 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.35 No.3
DL-Lactide and glycolide was synthesized from DL-lactic acid and glycolic acid with Sb₂O₃. We investigated the physicochemical properties of poly(DL-lactide-co-glycolide)(PLGA) synthesized in the ratio of 70:30, 80:20, and 90:10 from these dimers, respectively. Micelles containing clonazepam in PLGA core were prepared easily and in uniform bulk by dialysis methods. We investigated its applications in the drug delivery system(DDS). PLGA properties could be obtained variably in viscosity, average molecular weight, and melting point by copolymerization methods under different conditions of catalysts, temperature, reaction time, and solvents. Micelles of PLGA were made easily and in uniform bulk by dialysis methods and its loaded drug percentages showed 25.4, 23.4, and 22.3 %, respectively. Then the critical micelle concentrations(CMC) values of PLGA were 0.049(5.15×10^(-7)), 0.046(4.10×10^(-7)), and 0.033 ㎎/㎖(2.40×10^(-7) mole). In vitro drug release experiment showed the release time of drug delayed in the order of PLGA(70:30)>PLGA(80:20)> PLGA(90: 10). In short, biodegradable PLGA was prospected its applications probability in the micelles of delayed-action drug release and nanoparticle units.