부자(附子)와 오가피(五加皮) 물 추출물의 골수유래 지방세포와 파골세포 분화 억제 효과

이경선,최은식,한상용,김윤경,Lee, Kyung-Seon,Choi, Eun-Sik,Han, Sang-Yong,Kim, Yun-Kyung 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.1

Objectives : The aim of this study was to evaluate the efficacy of Aconiti Lateralis Preparata Radix (AP) and Acanthopanacis Cortex (AT) extracts in bone-derived adipocyte OP9 cell, osteoclast and osteoblast-like MG63 cells. Methods : MTT assay was used to evaluate the cytotoxicity of AP and AT extracts on OP9, osteoclast and MG63 cells. OP9 cells were treated with AP and AT, and the alterations in fat storage in the cells were determined by the Oil red O. To explain effects of RANKL-induced osteoclast differentiation in bone marrow macrophages, we performed the TRAP staining. The protein level of CAAAT/enhancer binding protein alpha ($C/EBP{\alpha}$) and peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) as a adipocyte differentiation marker, and adiponectin was examined using western blot in differentiated OP9 cells. Effects of related genes were confirmed by luciferase assay using reporter assay. Results : AP and AT was not toxic on OP9 and MG63 cells, but AT was a little cytotoxic to osteoclast at the dose of $100{\mu}g/m{\ell}$. They could inhibit differentiation of OP9 cells and osteoclast with results of oil red O staining and TRAP staining. By western blot, AP and AT decreased the expression of $PPAR{\gamma}$ and $C/EBP{\alpha}$ which is the key transcription factor in adipogenesis and adiponectin secretion. AT also inhibited the BMP-4 activity in luciferase assay. AP also inhibited BMP-4 and Wnt3a activity, stimulated ER-${\beta}$ activity but inhibited androgen receptor activity. Conclusions : These results show AP and AT can be useful in osteoporosis and obesity via inhibition of osteoclast and adipocyte differentiation.

통합예술치료 프로그램이 아동의 자기표현과 부모와의 의사소통에 미치는 효과

이경선(Lee Kyung Seon),곽현주(Kwak Hyun Ju) 한국통합예술심신치유학회 2017 통합심신치유연구 Vol.4 No.1

본 연구는 통합예술치료 프로그램이 아동의 자기표현과 부모와의 의사소통 향상에 미치는 효과를 알아보는데 그 목적이 있다. 본 연구의 대상은 K시 00동에 거주하는 9세∼11세의 아동으로 통합예술치료 프로그램에 참여의사를 밝힌 아동 16명의 연구대상자를 선정하였다. 통합예술치료 프로그램은 3개월 동안 주 1회, 60분씩 총 12회기로 진행되었다. 본 연구의 결과는 첫째, 통합예술치료 프로그램의 실시 전ㆍ후를 비교해 볼 때 실험집단의 자기표현전체 사전ㆍ사후에 유의미한 차이가 나타났다. 둘째, 통합예술치료 프로그램의 실시 전ㆍ후를 비교해 볼 때 실험집단의 부모-자녀의 의사소통, 부모-자녀의 개방적 의사소통에 유의한 차이를 보였다. 결론적으로 본 연구는 통합예술치료 프로그램을 통해 아동들의 자기표현과 부모와의 의사소통에 긍정적인 효과가 있었음을 알 수 있다. 따라서 통합예술치료 프로그램을 적용한 본 연구가 아동기에 부모-자녀간의 긍정적인 의사소통을 통하여 심리적 지원을 하였다는데 본 연구의 함의를 두고자 한다. The purpose of this study was to find out the effect of integrated art therapy program on self-expression of a child and communication between the parents and the child. The subjects for this study were 16 children aged from 9 to 11 living 00-Dong, K-City and agreed to participating the program and 8 of them were in experimental and others were in controlled group. The program were conducted for 3 months, once a week for 60 minutes each session and in a total of 12 sessions. The results of this study First, there were meaningful differences in a whole self-expression of experimental group when compared before and after the program. Second, there were meaningful differences in communication, open communication, between child and parents of experimental group when compared before and after the program. In conclusion, this study shows that the integrated arts therapy program has a positive effect on the self-expression of children and communication between children and parents. Therefore, it is meant that this study applying the integrated art therapy program can serve psychological support through positive communication between parents and children and served effective support to children.

8 . 삼국지연의의 성립과정

이경선(Kyung Seon Lee) 문창어문학회 1968 문창어문논집 Vol.7 No.-

속간사 ( Prefatory ) ( 문창어문학회 , 국어국문학지 , 1961년 2집 )

이경선(Kyung Seon Lee) 문창어문학회 1961 문창어문논집 Vol.2 No.-

N/A

연구논문 : 의약화학 ; 가래나무뿌리로 부터 세포독성 다이아릴햅타노이의 분리, 구조결정

이경선 ( Kyung Seon Lee ),이호 ( Gao Li ),이성환 ( Sung Hwan Kim ),이종순 ( Chong Soon Lee ),우미희 ( Mi Hee Woo ),이승호 ( Seung Ho Lee ),장영동 ( Yurng Dong Jhang ),손종근 ( Jong Keun Son ) 영남대학교 약품개발연구소 2003 영남대학교 약품개발연구소 연구업적집 Vol.13 No.-

한국비교문학을 위하여

이경선(Kyung Seon Lee) 문창어문학회 1959 문창어문논집 Vol.1 No.-

다시마 조체의 연화를 위한 첨가제의 효과

정인학,이경선,이강호,JEONG In-Hak,LEE Kyung-SEON,LEE Kang-Ho 한국수산과학회 1994 한국수산과학회지 Vol.27 No.2

다시마는 식품으로서 우수한 기능과 영양을 가지고 있지만 조체가 강인하여 제대로 식생활에 이용되지 못하고 있다. 본 연구는 동해산 다시마의 원료학적 특성과 다시마 조체를 연화할 수 있는 방법을 연구하여 다양한 다시마가공품의 개발로 소비를 촉진시키고자 하였다. 동해산 다시마는 회분이 건조중량으로 $34.74\%$ 함유되어 있는 훌륭한 무기질원이며 탄수화물이 $50.5\%$로 매우 높고 거의 대부분이 비소화성 성분으로 훌륭한 다이어트 식품이 될 수 있다. 유리 아미노산으로 Glutamic acid가 $2340mg\%$으로 매우 높게 함유되어 있는 우수한 조미재료이다. 다시마 조체의 연화에 중조는 크게 효과가 없었으나 초산과 인산염이 효과가 컸다. 초산은 $0.3\%$ 농도에서 1시간 자숙에 0.160kg/mm(${\pm}0.0494$), 2시간 자숙에 0.099kg/mm(${\pm}0.0207$) 값을 보여 충분한 연화에는 1시간 이상이 요구되었다. 인산염은 $0.2\%$에서 30분 처리만으로도 0.165kg/mm(${\pm}0.0540$)값을 보여 탁월한 연화효과를 나타내었다. 이상의 결과를 종합하면 다시마는 장시간 가열에 의해서도 상당한 수준까지 연화시킬 수 있으나 장시간 자숙처리는 다시마 조체 중에 함유되어 있는 $K^+,\;Ca^{2+},\;Mg^{2+},\;Na^+$ 등의 미네랄의 손실을 초래하게된다(좌등 등, 1981). 따라서 식초, 인산염 등을 적절히 사용하여 단시간에 연화를 완료시키는 가공방법이 바람직할 것이다. The hardness of kelp(Laminaria japonica) blade is a major deterrent to mass consumption in spite of its value as food. For improvement of kelp products as a special product of 'Donghae', the effect of additives on softening of kelp blade was studied. Kelp was composed of $34.74\%$ ash, $50.5\%$ carbohydrates, $4.81\%$ lipids and $9.98\%$ proteins on a dry weight basis. Glutamic and Aspartic acid are the principal free amino acids with percentage compositions of $2340mg\%\;and\;1650mg\%$ respectively of the $4719mg\%$ of total free amino acids. The softening effects of acetic acid and commercial mixed polyphosphate are more effective than that of monosodium carbonate. Boiling for more than 1hr was necessary for adequate softness of kelp blade in $0.3\%$ acetic acid solution. But, the kelp blade were softened more satisfactorily to 0.165kg/mm for only 30 min boiling in $0.2\%$ phosphate solution, and it is equal to boiling in $0.3\%$ acetic acid for 1hr.

다방향 멀티탭

김선필(Seon Pil Kim),정지민(Ji Min Jeong),강승태(Seung Tae Kang),김형우(Hyung Woo Kim),이지수(Ji Soo Lee),정선화(Sun Hwa Jeong),이경선(Kyung-Sun Lee) 대한인간공학회 2019 대한인간공학회 학술대회논문집 Vol.2019 No.10

체육인이 인식하는 리더 및 업무 역할의 성인지적 관점

곽선행(Kwak Seon-Hang),장덕선(Chang Duk-Sun),이경선(Lee Kyung-Sun) 한국체육과학회 2010 한국체육과학회지 Vol.19 No.4

This study tried to reflect gender-cognitive policies on the Korean sporting world and to provide basic sources in order to solve unfair factors in the policies efficiently. So, we studied the total of 31 people who are coaches, directors, athletic administrators, and physical researchers(F: 17, M: 14). We used open- ended questionnaire which is consist of 2 sectors, first, Recognition of leadership in the sporting world, second, Recognition of gender roles. Considering gender, categorized original date are named by reflecting the view of researchers as much as possible and we provided the categories and frequency. Firstly, people recognized themselves as a leader in the sporting world because they have event professionalism, practices in administration, love and interest in sports, academic professionalism, and responsibility. The reason why they are not leaders in the sporting world is that they don't have enough impact, don't have enough experience and lack of opportunity and other's recognition. Secondly, when they started to understand their job and role, they faced cultural bias. The good side is they could develop their career and get an opportunity to be grown, but the bad side is they felt social barriers and paradoxical benefits. They understand that female athletes' own jobs are considered that both genders can do it and can do as traditionally. Male athletes' own jobs are something external, traditional, and considered that both genders can do it.

낙동강 하구 주요 연안사주에서 표층표사의 시.공간적 변화

전용호,윤한삼,이경선,Jeon, Yong-Ho,Yoon, Han-Sam,Lee, Kyung-Seon 해양환경안전학회 2010 海洋環境安全學會誌 Vol.16 No.2

본 연구에서는 낙동강 하구 삼각주 지형의 형성 및 발달에 관한 기초적 현장조사 연구로서 사주 퇴적의 원인물질인 해안 표층표사의 퇴적속도를 정량적으로 평가하고자 하였다. 이를 위해 연안사주 중 진우도 및 도요등 전면해역의 사주퇴적현상이 급격하게 발생하는 해안선 지역에 표층 표사의 거동 분석을 위한 현장관측실험구를 설치하고 약 1년간 약 1개월 간격으로 지반고를 측정하여 그 결과를 분석하였다. 얻어진 결과를 요약하면 다음과 같다. (1) 관측기간동안의 일별 침식 퇴적속도 계산 결과, 진우도(St. 1)에서의 침식 퇴적속도는 -1.39~3.56cm/day이며, 도요등(St. 2)의 경우에는 -4.0~3.07cm/day이었다. (2) 관측기간동안 2회의 태풍 내습에도 침식 및 퇴적량이 그리 크게 나타나지 않는 반면에 태풍내습후 10월경에 최대 표사이동량이 나타났다. We conducted a field survey of the generation and development of the delta area of the Nakdong River estuary, Korea. To examine deposition and erosion of the barrier islands, we observed the spatiotemporal variations of sediment transport and quantitatively estimated the settling velocity of coastal sediment. For the field survey, we established two survey sites off the coasts of Jinu Island and Doyodeung, which had shown rapid variations in deposition and erosion. At these sites, we measured the net surface elevation change of the bottom level at approximately 1-month intervals. Main findings were summarized as follows. (1) Calculated daily deposition and erosion velocity during the observation period ranged from -1.39 to 3.56cm/day at Jinu Island and from -4.0 to 3.07cm/day at Doyodeung, respectively. (2) Although two typhoons passed by the study area during the observation period, the maximum net surface elevation was larger in October than during the passage of those typhoons.