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Expression Patterns of Immune Related Genes in Th1 and Th2 Cells Revealed by Microarray Analysis
이갑열 한국유전학회 2007 Genes & Genomics Vol.29 No.4
T helper cells play a distinct role in activating and regulating immune responses. Th1 cells mediate cellular immunity by activating macrophages, whereas Th2 cells mediate humoral immunity by activating B cells. The differentiation of Th1 and Th2 cells accompany drastic changes in immune function, cellular metabolism, gene expression, chromatin structure, and cell morphology. To search for more information on the immune functions of Th1 and Th2 cells, we examined a gene expression profile in immune related genes by microarray analysis. As expected many differentiation-specific cytokine, chemokine, and transcription factor genes are differentially expressed. I also discovered that a group of interferon-regulated genes is selectively expressed in Th1 cells, and that a group of immunoglobulin genes and various types of cell surface receptors are selectively expressed in Th2 cells. These studies extend the current understanding of immune function of T helper cells and find more molecules involved in the T helper cell differentiation.
Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization
이갑열 대한면역학회 2023 Immune Network Vol.23 No.1
Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.
세그멘트 폴리우레탄 우레아에 기초한 블렌드계 고체전해질의 분자운동성과 이온 전도성
이상걸,이갑열,조남주 부산대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.59 No.-
순수 고체 전해질과 겔형 고분자 전해질의 장점을 취합한 새로운 형태의 블렌드계 고체 전해질을 제조할 목적으로, 현재 유기 가소제로 널리 쓰이는 ethylene carbonate(EC), propylene carbonate(PC) 대신 실온에서 휘발성이 낮은 저분자량의 polyethylene g1ycol(PEG) 및 polyethylene glycol dimethylether(PEGDME)를 사용하였다. 또한, 고분자 매트릭스로는 지지체 역할 뿐만 아니라 염과의 복합체를 형성할 수 있도록 soft segment에 PEO/PPO 공중합체를, hard segment urea기를 도입한 세그멘트 폴리우레탄 우레아(segmented polyurethane urea, SPUU)를 사용하였다. 제조된 SPUU팀에 휘발성이 낮은 저분자량의 PEC 및 PEGDME와 리튬염을 부가하여 solution casting법으로 블렌드계 고체 전해질을 제조한 다음 교류 임피던스법으로 이온 전도도를 측정하였다. 이때 이온 전도도는 PEO 및 PEGDME의 분자량 및 함량에 의존함을 관찰할 수 있었다. In order to prepare a new blend-type electrolyte possessing the merits of both an intrinsic polymer electrolyte and gel-electrolyte, we report on a class of nonvolatile (dry) polymer electrolyte, prepared by plasticizing a segmented polyurethaneurea (SPUU) with solution of lithium salt in oligomeric poly(ethylene glycol) (PEG) and poly(ethylene glycol) dimethyl ethers (PEGDME). SPUU having PEO/PPO copo1ymer in soft segment and urethanerurea group in hard segment was used in order to prepare a mechanically stable blend-type electrolyte for for improving the affinity between PEC or PEGDME and matrix. and the ionic conductivity was measured by AC impedance spectroscopy. As a result, it was observed that the ionic conductivity depended on the molecular weight and contents of PEC and PEGDME.